Archives August 2019

Cerebral organoids produce complex brain waves similar to newborns’

Source STAT The Lilliputian versions of human brains that scientists have grown in lab dishes have developed distinct structures such as the hippocampus, grown glia and other cells like those in actual brains, and produced a diverse menagerie of neurons that connect with each other and carry electrical signals. Now scientists have grown hundreds of cerebral organoids

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The Era Of Personalized Medicine Has Arrived – PMC’s Annual Progress And Outlook Report

The Personalized Medicine Coalition (PMC) released its annual “Personalized Medicine At FDA: A Progress & Outlook Report” (Report) that monitors current successes and challenges in bringing personalized therapies to market. Notable Developments for 2018 Several milestones were noted for 2018 – ranging from new drug approvals to direct-to-consumer genetic testing. 1.            A record number of

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Toward a unified theory of aging and regeneration

Source https://www.futuremedicine.com/doi/full/10.2217/rme-2019-0062 Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic

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Addition of growth factors to unique system helps new bone formation

The development of new bone can be a multistep process: first, stem cells differentiate into cartilage cells. Next, the cartilage cells become bone cells. But that’s not all: the cells must experience some mechanical stresses during the transformation in order to transform efficiently from stem cells to bone cells. Researchers at the University of Illinois

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Thirty patient deaths tied to cystic fibrosis drug following FDA database of side effects

Thirty patients have died after taking Symdeko, a Vertex Pharmaceuticals treatment for cystic fibrosis, according to a government database. The deaths, reported to the Food and Drug Administration’s database of side effects, are tied to Symdeko, a Vertex medicine approved last year. Reports to the database are commonly submitted by health care professionals and often contain

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The International Space Station Has a New Partner in Regenerative Medicine

Scientific investigations conducted by people on the International Space Station (ISS) are currently contributing to our knowledge in many fields. The research alliance between the University of Pittsburgh’s (Pitt) McGowan Institute for Regenerative Medicine (MIRM) and the ISS is a great example of the ultimate vision of a space development that could result in the advancement of biomedical products in space,

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Memo to Italy’s president: your researchers need you

The collapse of Italy’s coalition government has left researchers vulnerable. The president should use his moral authority with party leaders to make sure that promises of increased funding are kept. Source Nature 572, 563 (2019)doi: 10.1038/d41586-019-02560-1 Last week, Italy’s coalition government ended abruptly, when the nationalist Lega party of deputy prime minister Matteo Salvini announced that

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Mesenchymal stem cells in allergic diseases: Current status

Allergic diseases have become a global health problem and the most prevalent allergic disorders include allergic asthma, allergic skin diseases, allergic rhinitis, and allergic conjunctivitis. In the therapy of allergic diseases, corticosteroids, antihistamines, antileukotrienes and β2 adrenergic receptor agonists temporarily inhibit inflammation mediators and immune cells. However, long-term treatment causes various adverse effects. Drug resistance and intolerance

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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Alternate-day fasting (ADF) had positive effects on body weight, cardiovascular measures, and molecular markers of aging when assessed in a randomized controlled trial among healthy adults without obesity or diabetes, researchers report in a study published online August 27 in Cell Metabolism. ADF is a different approach to control weight than the common caloric restriction (CR) or intermittent fasting (IF)

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