Category REGENERATIVE MEDICINE

ILLUMINATING THE BRAIN WARREN ALPERT FOUNDATION AWARD GOES TO FOUR SCIENTISTS FOR SEMINAL DISCOVERIES IN OPTOGENETICS

Harnessing light and genetics, the approach illuminates and modulates the activity of neurons, enables study of brain function and behavior, sets stage for optogenetic therapies The 2019 Warren Alpert Foundation Prize has been awarded to four scientists for pioneering work in the field of optogenetics, a revolutionary technique that uses light and genetic modification to

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Surgical and tissue engineering strategies for articular cartilage and meniscus repair

Source https://www.nature.com/articles/s41584-019-0255-1 Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately results in arthritis. Different forms of arthritis affect ~50 million people in the USA alone, and it is therefore crucial to identify methods that will halt or slow the progression to arthritis, starting with the initiating events of cartilage and

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Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Since both myocardium and vasculature in the heart are excessively damaged following myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently target both so as to achieve true cardiac repair. Here we demonstrate a concomitant method that exploits the advantages of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) and human mesenchymal

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Induced Pluripotent Stem Cell (iPSC)–Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges

The advancement of adoptive cell immunotherapy and the impressive clinical outcomes obtained targeting hematologic malignancies with CAR-T cells dictate for further developments towards a broader use of cellular therapeutics for more patients and more types of malignancy. The advent of iPSC technology provides new perspectives for the manufacturing of customized, tumor-targeting T/NK cells, with improved

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Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft

tem cell therapies have the potential to treat many conditions, but so far there’s little proof that they do. Even so, clinics around the world offer stem cell-based treatments for a host of medical problems. New research warns that some of these treatments might not be effective and can, in fact, cause harm — sometimes

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Supercharging CAR-T with cancer vaccine, MIT team spotlights some new tech underpinning Darrell Irvine’s startup

Many of the efforts to improve on the first generation of CAR-T therapies such that they can reach solid tumors had focused on tweaks inherent to the cancer killing agent — specifically, utilizing more potent T cells as their base, from stem memory T cells to virally associated T cells to marrow infiltrating lymphocytes. But

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Developing Treatments for Blindness: Gene Therapy Shown to Restructure Retinas

A new study, carried out on mice, shows great promise for developing treatments that restore vision in blind people. According to researchers, gene therapy is helping the retina to restructure itself, regain normal light responses and, ultimately regain vision in mice.  A paper, published in JNeurosci, outlines the findings and supports the continued development of treatments for

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First step to induce self-repair in the central nervous system

Injured axons instruct Schwann cells to build specialized actin spheres to break down and remove axon fragments, thereby starting the regeneration process Damaged peripheral nerves can regenerate after an injury, for example, following a forearm fracture. Axons, the long projections of neurons that transmit stimuli or signals to other cells, are affected in the case

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