All posts by PIER MARIA FORNASARI

PIER MARIA FORNASARI
2020-02-02

Mayo Clinic CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue–Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury

Stem cells derived from a patient’s own fat offer a step toward improving—not just stabilizing—motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic. A clinical trial enrolled 10 adults to treat paralysis from traumatic spinal cord injury. After stem cell injection, the first patient demonstrated improvement in motor

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No Comments InCELL THERAPY
PIER MARIA FORNASARI
2020-02-02

HER2-Directed CAR T-Cell Therapy Appears Active in Phase I Trial for Advanced Sarcoma

Source Targeted Oncology Patients with sarcomas, including osteosarcoma in particular, have limited treatment options available, and the landscape has not advanced in over 40 years, according to Shoba A. Navai, MD. However, trials are now evaluating the potential role of chimeric antigen receptor (CAR) T cells as treatment of patients with sarcoma. In a phase

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No Comments InCAR-T
PIER MARIA FORNASARI
2020-02-02

University of Hong Kong Researchers forecast up to 75,800 People in Wuhan Infected With Coronavirus

The University of Hong Kong researchers used mathematical modeling to come up with the new estimate. With coronavirus panic raging, researchers are racing to determine how widespread the virus actually is. A group of them from the University of Hong Kong think they have the answer, estimating it stands at 75,800 in the city of

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No Comments InCORONAVIRUS CHINA
PIER MARIA FORNASARI
2020-01-31

UNC Lineberger discovery would allow researchers to fine-tune activity of CAR-T cancer-hunting immune cells

A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease their activity level in the case of severe side effects. In a study published in Cancer Cell, researchers led by UNC Lineberger’s Gianpietro Dotti, MD, reported

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No Comments InCAR-T
PIER MARIA FORNASARI
2020-01-31

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Source Cell Metabolism Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, it’s reported that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. Depletion of

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No Comments InAGEING
PIER MARIA FORNASARI
2020-01-30

NUS Medicine researchers can now reprogramme cells to revert to original state for regenerative medicine

Inducing totipotency into stem cells outside of embryos will allow maximal cell engineering for therapeutic purposes Early mammalian development is a highly complex process involving elaborate and highly coordinated biological processes. One such process is zygotic genome activation (ZGA) which occurs following the union of the sperm and egg, marking the beginning of life. The

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No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2020-01-30

Penn Researchers Identify Cancer Cell Defect Driving Resistance to CAR T Cell Therapy

Study identifying mechanism that prevents cell death may guide future immunotherapy strategies Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why. In a new study, researchers describe how a

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No Comments InCAR-T
PIER MARIA FORNASARI
2020-01-30

Stem Cells, CRISPR and Gene Sequencing Technology are Basis of New Brain Cancer Model

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time. “We have developed stem cell models that are CRISPR-engineered to have tumor-associated driver mutations

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No Comments InCANCER
PIER MARIA FORNASARI
2020-01-30

University of Melbourne scientists first to grow and share novel coronavirus

Scientists from the Peter Doherty Institute for Infection and Immunity – a joint venture between the University of Melbourne and the Royal Melbourne hospital – have successfully grown the Wuhan coronavirus from a patient sample, which will provide expert international laboratories with crucial information to help combat the virus. This is the first time the virus has

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No Comments InCORONAVIRUS CHINA
PIER MARIA FORNASARI
2020-01-30

Buck researchers discover how cellular senescence leads to neurodegeneration

Although a link has been established between chronic inflammation and neurodegenerative diseases, there have been many open questions regarding how cellular senescence, a process whereby cells that stop dividing under stress spew out a mix of inflammatory proteins, affects these pathologies. Publishing in PLOS One, researchers at the Buck Institute report that senescence in astrocytes, the most

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No Comments InWELLNESS