Researchers have discovered that a key cell type involved in liver injury and cancer consists of two cellular families with different origins and functions. The research by academics from the Universities of Edinburgh and Bristol and funded by the Wellcome Trust and Medical Research Council, is published today [Tuesday 15 October] in Nature Communications. The distinguishing
Owkin publishes breakthrough research in Nature Medicine Owkin, which is developing machine learning technologies to advance medical research, today announces publication of a paper in Nature Medicine that showcases its breakthrough analysis of tumour biology using interpretable deep-learning models. The paper entitled ‘Deep learning-based classification of mesothelioma improves prediction of patient outcomes’ describes how Owkin
A California “human biohacking” bill calls for warnings on do-it-yourself genetic-engineering kits. Source Technology Review It’s going to be illegal in California to sell “gene-therapy kits” unless they carry a warning that says not to use them on yourself. Just one wrinkle: we’re not sure any such kit exists. Not yet, anyway. The consumer protection
The process could be harnessed as a treatment for osteoarthritis Source Duke Health Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found. Publishing online Oct. 9 in the journal Science Advances,
Researchers rapidly corrected finding through discussions on social media and preprints. Source Nature A study that raised questions over the future health of the world’s first gene-edited babies has been retracted because of key errors that undermined its conclusion. The research, published in June 2019 in Nature Medicine1, had suggested that people with two copies of a natural genetic mutation
Neurologic scores stabilized, seizures diminished with tailored antisense oligonucleotide therapy The researchers who developed a personalized antisense oligonucleotide (ASO) for a little girl with a form of Batten disease — all in record time — have detailed their case in the New England Journal of Medicine. Timothy Yu, MD, PhD, of Boston Children’s Hospital, and colleagues explained how
Subretinal administration of the gene therapy AAV2/5-OPTIRPE65 showed improvements in vision-guided mobility, retinal sensitivity, and foveal-driven visual function for patients with RPE65-associated retinal dystrophy, according to findings from a phase 1/2 study presented at the 2019 American Academy of Ophthalmology Annual Meeting. In the early-stage study, there was a significant change in the ability to complete a
Analytics firm Elsevier has teamed up with non-profit phactMI to develop a new solution for providing scientifically accurate information to healthcare professionals. The deal will leverage Elsevier’s Entellect life sciences platform to create a semantic search portal. Scheduled to launch in the fourth quarter of this year, the new solution will facilitate rapid access to
Source: H. Lee Cancer Center & Research Institute Patients with advanced melanoma have been able to live longer because of several newly approved targeted treatment options, including BRAF and MEK inhibitors. However, patients will often have different responses to the same treatment due to genetic variability. Melanoma varies from patient to patient, but genetic variability is
The country’s health department is now sharing study results on new drugs and treatments online. Transparency advocates want the U.S. to do the same. Health Canada has posted safety and efficacy data online for four newly approved drugs; it plans to release reports for another 13 drugs and three medical devices approved or rejected since March. Source
