A new gene therapy turns glial cells — abundant support cells in the brain — into neurons, repairing damage that results from stroke and significantly improving motor function in mice. A paper describing the new therapy, which uses the NeuroD1 gene, appears online in the journal Molecular Therapy. Once further developed, this NeuroD1-based gene therapy potentially
Regulators in the U.S. and Europe are investigating why traces of a possible carcinogen were found in certain heartburn drugs, including Zantac, more than a year after the same impurity was found in some blood pressure pills, a revelation that has raised questions about the safety of the pharmaceutical supply chain. At issue is NDMA,
If healthcare organizations want to succeed in an environment of digital transformation, they must bring about participatory health. That shift will require providers to be grounded in patient engagement and patient-centered care—by being “on-demand, connected and data-driven.” That’s the contention of a new report from the American Hospital Association’s Center for Health Innovation, and EY, which examines
Source Army.mil Doctors from 12 specialties taught 26 participants on required virtual health presentation skills at the eighth tri-service, inter-agency Virtual Health Patient Presenter course Sept. 9 – 13 at Landstuhl Regional Medical Center. The one-week course gave nurses, Army medics, Air Force medical technicians and Navy corpsmen hands-on instruction from specialty physicians and physician
Stem cell therapy, or stem cell transplant, is an emerging yet controversial treatment approach for multiple sclerosis (MS). While some data uphold it as one of the most efficacious MS treatments, to date there have been no controlled studies comparing it to conventional medicines and providing more robust evidence regarding its safety and clinical benefit. Under the topic
Source Targeted Oncology JAK inhibition continues to drive progress in myelofibrosis treatment as fedratinib (Inrebic) now joins ruxolitinib (Jakafi) in the treatment landscape for myelofibrosis. Since its FDA approval in August 2019, fedratinib has become both an additional treatment and a second-line option for patients who respond poorly to ruxolitinib. The approval of fedratinib was
Penn study finds immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients’ own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease. In a first-of-its-kind study, published today in Nature, researchers
The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes and compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpoint receptors simultaneously on CAR-T cells and that show the resulting PTL-CAR-T cells undergo epigenetic modifications and better control
Nanoparticles hold great promise for delivering next-generation therapeutics, including those based on CRISPR gene editing tools. The challenge is how to guide these tiny particles through the bloodstream and into the right target tissues. Now, scientists are enlisting some surprising partners in this quest: magnetic bacteria! Source NIH Director First a bit of background. Discovered in
The EU needs an ambitious and coherent agenda for the 2019-2024 legislative term to boost the resilience, equitability and sustainability of Europe’s healthcare systems. This report, based on a Science|Business expert roundtable, sets out recommendations for such an agenda. When it comes to healthcare, Europe has strong foundations on which to build. It already has
