Penn study finds immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients’ own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease. In a first-of-its-kind study, published today in Nature, researchers
The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes and compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpoint receptors simultaneously on CAR-T cells and that show the resulting PTL-CAR-T cells undergo epigenetic modifications and better control
Nanoparticles hold great promise for delivering next-generation therapeutics, including those based on CRISPR gene editing tools. The challenge is how to guide these tiny particles through the bloodstream and into the right target tissues. Now, scientists are enlisting some surprising partners in this quest: magnetic bacteria! Source NIH Director First a bit of background. Discovered in
The EU needs an ambitious and coherent agenda for the 2019-2024 legislative term to boost the resilience, equitability and sustainability of Europe’s healthcare systems. This report, based on a Science|Business expert roundtable, sets out recommendations for such an agenda. When it comes to healthcare, Europe has strong foundations on which to build. It already has
A new report has found that Medical Research Council (MRC) funding schemes for translational research have boosted the UK’s life sciences industry since they were introduced in 2008. Over £530 million of new translational research funding since 2008 has led to MRC-linked spin-outs securing £1.1 billion in private sector investment and delivering health benefits, such as new
Source Il Messaggero Matilde Leonardi, director of the Coma Research Center of the Besta Neurological Institute in Milan and a member of the Italian Society of Neurology, wants to be immediately clear. “The news about the former pilot is only fueling false hopes and deluding patients’ families.” Why is she so convinced that this therapy
The School of Engineering and Applied Science announced late last month that a mechanical and aerospace engineering professor received $300,000 from the American Heart Association to develop a device that can print tissue used for repairing heart damage. The AHA – a nonprofit organization that funds cardiovascular research – granted a three-year award to Lijie
Bulgaria’s Mariya Gabriel picked to lead newly named policy department that combines research with education and youth affairs. Source Nature Bulgarian political scientist Mariya Gabriel has been nominated as the European Union’s next commissioner for research — but, for the first time in the bloc’s history, the name of her department will not include that
Biofabrication holds great potential to revolutionize important industries in the health, food, and textile sectors, but its translation to market is still challenging. Pedro F. Costa in a paper newly published on Trends in Biotechnology analyzes the current state of innovation and commercialization in biofabrication and try to assess its limitations, strengths, and future progress.
Researchers have developed a neural network approach that can accurately identify congestive heart failure with 100% accuracy through analysis of just one raw electrocardiogram (ECG) heartbeat, a new study reports. Nearly 10 percent of adults over the age of 65 suffer from some kind of congestive heart failure (CHF). There are a variety of different
