Cambridge scientists reverse aging process in rat brain stem cells

New research reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state.  New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem

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An Organ-On-A-Chip Engineered Platform to Study the Microbiota–Gut–Brain Axis in Neurodegeneration

A Novel Hypothesis: The Microbiota–Gut–Brain Axis The two most common neurodegenerative disorders have a very long history. The first reported case of Alzheimer’s disease (AD) was in 1906, while Parkinson’s disease (PD) was described in 1817. Since then, intensive research has provided plenty of clinical, genetic, and molecular evidence of AD and PD signs, mechanisms,

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Novartis ousted top scientists over manipulation of data for gene therapy

Source STAT Novartis dismissed the top two scientists at its gene therapy division shortly after CEO Vas Narasimhan learned of internal data falsification that has since snowballed into a damaging scandal, a person familiar with the situation said Wednesday. The company previously said it was “in the process of exiting” scientists who were responsible for

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Artificial intelligence helps detect atrial fibrillation

Researchers in the US have developed a rapid, artificial intelligence (AI)-based test that can identify patients with an abnormal heart rhythm, even when it appears normal. This 10 second test for atrial fibrillation could be a significant improvement over current test procedures that can take weeks or even years (Lancet 10.1016/S0140-6736(19)31721-0). Atrial fibrillation is a common

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What are the top five clinical applications of paediatric 3D printing?

What are the most common clinical applications for 3D-printed models created from MRI scans of paediatric patients? A team from Ohio explored the various applications and the role radiologists play in production of the models in a new article, recently published online in the Journal of Magnetic Resonance Imaging. “We wanted to investigate 3D printing with

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Tissue model reveals role of blood-brain barrier in Alzheimer’s

Study finds that Alzheimer’s damage allows toxins to enter the brain, further harming neurons. Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer’s patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier — the normally tight border that prevents harmful molecules in the bloodstream from

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New soft neural implant can be wirelessly controlled using a smartphone

Researchers have developed a soft neural implant that can be wirelessly controlled using a smartphone. It is the first wireless neural device capable of indefinitely delivering multiple drugs and multiple colour lights, which neuroscientists believe can speed up efforts to uncover brain diseases such as Parkinson’s, Alzheimer’s, addiction, depression, and pain. A team under Professor

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