FDA greenlights blood detox device to combat COVID-19’s cytokine storms

The FDA has granted an emergency authorization to a blood purification system to treat patients with the most severe cases of COVID-19. The device is designed to strip out an excess of immune system-triggering proteins from blood and plasma before returning them back to the patient—including those that fuel cytokine storms, the harmful, cascading activation

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‘It’s a humanitarian effort’: Led by Takeda and CSL Behring, a plasma coalition forms to fight COVID-19

A new, worldwide coalition of plasma companies seeking to develop and deliver a hyperimmune immunoglobulin therapy for fighting COVID-19 takes the view that many hands make light work. Takeda Pharmaceutical Co. Ltd. and CSL Behring LLC created the group, with Germany’s Biotest AG, the U.K.’s Bio Products Laboratory, France’s LFB SA and Switzerland’s Octapharma AG joining the alliance to immediately begin developing a

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How to support online learning during COVID-19 pandemic

A new report offers guidance to school districts straining to adjust A new report offers guidance to K-12 teachers, principals and superintendents, as well as schools of education, on how to handle the increasing stress of adapting education systems to the realities of the COVID-19 pandemic. “Evidence from the Great Recession suggests the lasting damage that society-disrupting

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What is required to prevent a second major outbreak of SARS-CoV-2 upon lifting the quarantine of Wuhan city, China

This paper aims to determine to what level of the two commonly used control measures, social distancing and facial mask usage, are necessary to prevent a resurgence of the epidemic due to eitherresidual active cases in Wuhan or imported cases after lifting the quarantine, examining in a model six proposed dates for quarantine lifting. The

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New clinical trial launches to test efficacy of cell therapy for severe COVID-19 cases

After a lightening round of proposals and reviews, an international team of scientists led by Dr. Camillo Ricordi was granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) to block the life-threatening lung inflammation that accompanies severe cases of COVID-19. We are very

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Time to encourage people to wear face masks as a precaution against Covid-19, say experts

It’s time to encourage people to wear face masks as a precautionary measure on the grounds that we have little to lose and potentially something to gain, say experts in The BMJ today. Source The BMJ Professor Trisha Greenhalgh at the University of Oxford and colleagues say despite limited evidence, masks “could have a substantial impact on

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Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. A just published paper on Cell Press

The crystal structure of the C-terminal domain of the SARS-CoV-2 spike protein in complex with human ACE2 reveals insights into the mechanisms of binding of this virus and its differences from SARS. SARS-CoV-2 interacts with hACE2 via S protein CTD A 2.5-A˚ structure of SARS-CoV-2-CTD in complex with hACE2 is resolvedSARS-CoV-2-CTD displays stronger affinity for

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