Stem cell-based therapies for Duchenne muscular dystrophy

Scientists of John Hopkins University School of Medicine summarize the current methods of human pluripotent stem cells (HPSCs) myogenic commitment/differentiation, and describe the current status of hPSC-derived myogenic cell transplantation. Muscular dystrophies are a group of genetic muscle disorders that cause progressive muscle weakness and degeneration. Within this group, Duchenne muscular dystrophy (DMD) is the

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Stem Cell Therapy for ALS

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease and Lou Gehrig’s disease, is a rare condition characterized by the degeneration of nerve cells that control voluntary muscles. The disease leads to gradually worsening symptoms that include muscle weakness, twitching, and stiffness. As more of these nerve cells, or motor neurons, are lost, muscles decrease in size

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Overcoming the barriers to cell and gene therapies in Europe. BIA and ARM position

By Annie Hubert, Senior Director, European Public Policy at Alliance for Regenerative Medicine ATMPs are varied and complex, ranging from potential one-off curative treatments to treatments tailored to a specific individual. As such, they differ significantly from ‘traditional’ medicinal treatments, something which has been recognised by regulators in Europe: the European Parliament introduced ATMPs as a

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New Automation Solution to Accelerate Cell and Gene Therapy Manufacturing Announced

Terumo BCT’s latest cell therapy technology, the Finia® Fill and Finish System, is a first-of-its-kind device developed to help bring reproducibility and control to cell therapy manufacturing to get therapies to more patients who need them. Finia is a fully automated, modular, functionally closed system that creates the final formulation of cell and gene therapies

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Stem Cells Present Parallel Opportunities for Pelizaeus-Merzbacher disease

Two new studies by an international team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age. Often diagnosed at birth with symptoms of weakness and breathing difficulties, the progressive neurological problems in PMD

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Society of Hematologic Oncology 2019 : The future of cellular therapy in hematological malignancies

The number of cancer cell therapies has increased considerably over the last few years.1 There are several different types of cellular therapies, including chimeric antigen receptor (CAR) T cells, multiple tumor-associated antigen-specific T cells (TAA-T), natural killer (NK)-based therapies and T-cell therapies based on novel technologies like CRISPR.1 Amongst the different types of cell therapies in development,

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Stem Cell Therapy for Amyotrophic Lateral Sclerosis

Source ALS News Today Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease and Lou Gehrig’s disease, is a rare condition characterized by the degeneration of nerve cells that control voluntary muscles. The disease leads to gradually worsening symptoms that include muscle weakness, twitching, and stiffness. As more of these nerve cells, or motor neurons, are lost,

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Stem cell treatments for shoulder and elbow injuries flourish, but so far there’s little evidence they work

Two critical reviews examine the current status of biologic approaches for common shoulder and elbow problems. The authors discuss areas where the current evidence base is weak or controversial and recommend where further studies are required. The utilization of stem cell therapies for augmentation of tissue healing has far outpaced the supporting scientific and clinical

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