Category REGENERATIVE MEDICINE

PIER MARIA FORNASARI
2026-03-30

New Regimen with Aurora kinase A inhibitor Protects Against Cancer Relapse, Graft-Versus-Host Disease After Donor Stem Cell Transplant

Results of a phase 1 clinical trial show that patients who undergo a blood stem cell transplant involving a donor have a lower risk of relapse and lower rates of graft-versus-host disease when they receive the targeted therapy VIC-1911 along with the standard-of-care regimen that includes post-transplant cyclophosphamide and sirolimus. Led by Shernan Holtan, MD, Chief of Blood

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No Comments InCANCER CELL THERAPY
PIER MARIA FORNASARI
2026-03-29

American College of Cardiology Scientific Statement Highlights Emerging Role of Gene Editing in Cardiovascular Care

A new ACC Scientific Statement outlines the rapidly evolving landscape of gene-editing therapies and their growing relevance to cardiovascular disease, offering clinicians an overview of both the promise and the challenges of this transformative technology. Advances in genome sequencing have dramatically expanded access to genetic testing, improving availability while reducing cost. At the same time, technological

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No Comments InGENE EDITING
PIER MARIA FORNASARI
2026-03-13

Revealing How Transplanted Neural Stem Cells Preserve Vision

Cedars-Sinai investigators working to optimize a cell-based treatment for retinitis pigmentosa have uncovered how transplanted neural stem cells interact with host retinal cells to preserve vision. The findings, published in Nature Communications, may guide future research toward strategies to treat degenerative eye disease. “We used single-cell analysis to show that neural stem cells can protect vision in

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No Comments InCELL THERAPY REGENERATIVE MEDICINE
PIER MARIA FORNASARI
2026-03-11

A 3D printable scaffold to support fast bone growth

A bone-like composite developed at EPFL uses naturally occurring enzymes to accelerate mineralization through an energy-efficient, room-temperature process. The strong, lightweight material shows promise for bone repair applications. Inspired by the resilient and self-repairing mechanical properties of bone, scientists have been developing synthetic materials using one of bone’s main components: a mineral called hydroxyapatite (HA).

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No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2026-03-05

Cloaked Stem Cells Evade Immune Rejection in Mice, Pointing to a Potential Universal Donor Cell Line

A study published today in Stem Cell Reports demonstrates that genetically engineered human pluripotent stem cells (hPSCs) can overcome immune rejection in mice with humanized immune systems, surviving for five months in a stringent transplantation model. The findings provide proof-of-principle for the development of a potential universal donor hPSC line designed to resist immune attack. Led by Danny Chan,

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No Comments InCELL THERAPY iPS cells REGENERATIVE MEDICINE
PIER MARIA FORNASARI
2026-02-18

Researchers Develop New Method for Generating up to 14 milions Natural Killer Cells to Fight Cancer from a single CD34+ HSPC.

Chinese researchers have developed a novel method to efficiently engineer natural killer (NK) cells for cancer immunotherapy. NK cells are central to early antiviral and anticancer defense—among other immune system roles—making them well-suited for cancer immunotherapy. For example, chimeric antigen receptor (CAR)-NK therapy involves adding a lab-built receptor (a CAR) to an NK cell, enabling

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No Comments InCANCER CAR-T IMMUNOTHERAPY
PIER MARIA FORNASARI
2026-02-14

Cell and gene therapy across 35 years

Cell and gene therapies, or CGT, have come a long way since they were first introduced. In the last few decades, both cell therapy — the transplantation of living cells — and gene therapy — the use of genetic material to modify cell functions — have been increasingly incorporated into clinical practice. Various challenges and advances

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No Comments InADVANCED THERAPY MEDICINAL PRODUCT CELL THERAPY GENE THERAPY RARE DISEASES REGENERATIVE MEDICINE
PIER MARIA FORNASARI
2026-01-25

ISSCR Develops Roadmap to Accelerate Pluripotent Stem Cell-Derived Therapies to Patients

“Charting the Translational Pathway: ISSCR Best Practices for the Development of PSC-Derived Therapies,” offers insights into the comprehensive, globally informed guide to navigating the complex journey from laboratory discovery to approved therapy. The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of “Charting the Translational Pathway: ISSCR Best Practices for the

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No Comments InCELL THERAPY
PIER MARIA FORNASARI
2025-12-26

A possible new treatment for impaired brain blood flow and related dementias is on the horizon.

Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides novel insights into the mechanisms that regulate brain blood flow and highlight a potential therapeutic strategy to correct vascular dysfunction. Their preclinical findings, published December 22 in Proceedings of the National Academy of Sciences, suggest that adding a missing phospholipid back into a

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No Comments InAGEING RESEARCH