Clusters of living brain cells are teaching scientists about diseases like autism. With a new finding, some experts wonder if these organoids may become too much like the real thing. Source The New York Times Two hundred and fifty miles over Alysson Muotri’s head, a thousand tiny spheres of brain cells were sailing through space. The clusters,
New research published in the ‘Journal of Dental Research’ has shed light on the science behind the formation of the periodontal ligament Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer. Now new research
Harvard scientists have combined organ-on-a-chip and stem-cell technologies to make a powerful tool for diabetes research and beta-cell transplantation By combining two powerful technologies, scientists are taking diabetes research to a whole new level. In a study led by Harvard University’s Kevin Kit Parker and published in the journal Lab on a Chip on Aug. 29, microfluidics and human,
A promising new treatment for cancer patients has received approval from the Centers for Medicare and Medicaid Services, paving the way for more patients to get the treatment known as CAR T-cell therapy. While this decision will likely expand access, particularly for some lymphoma and leukemia patients, treatment remains prohibitively expensive, prompting some patients to opt for experimental rather
A research team from Osaka University said Thursday it had conducted the world’s first transplant of corneal tissues using artificially derived stem cells in July. The university’s team, led by Koji Nishida, may have created a new treatment for those suffering from corneal disease, as current treatment procedures involve waiting for corneal donations from deceased
The use of human embryonic stem cell (hESC)-derived Retinal Pigment Epithelium (RPE) transplants has advanced dramatically in different forms for clinical application in macular degeneration. This review focuses on the first generation of hESC-RPE cell line, named as “MA09-hRPE” by Astellas Institute of Regenerative Medicine (AIRM), and its therapeutic application in human, which evaluated the
Dr Shona Lang investigates the advantages and disadvantages of using organoids within R&D, highlighting the most important questions to ask before using these models. Source Drug Target Review Organoids are three-dimensional (3D) cell cultures which mimic tissue architecture. Their growing importance in various fields of research saw them named ‘Method of the Year 2017’1 and their
Source STAT The Lilliputian versions of human brains that scientists have grown in lab dishes have developed distinct structures such as the hippocampus, grown glia and other cells like those in actual brains, and produced a diverse menagerie of neurons that connect with each other and carry electrical signals. Now scientists have grown hundreds of cerebral organoids
Source https://www.futuremedicine.com/doi/full/10.2217/rme-2019-0062 Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic
The development of new bone can be a multistep process: first, stem cells differentiate into cartilage cells. Next, the cartilage cells become bone cells. But that’s not all: the cells must experience some mechanical stresses during the transformation in order to transform efficiently from stem cells to bone cells. Researchers at the University of Illinois
