A group of researchers at Osaka University revealed that endothelial cell-selective adhesion molecule (ESAM), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis. Their research results were published in Stem Cell Reports. In hematopoiesis,
Researchers from EMBL and the German Cancer Research Center (DKFZ) in Heidelberg have developed new methods to reveal the three-dimensional organisation of bone marrow at a single cell level. Since bone marrow harbours blood stem cells responsible for life-long blood generation, these results and the new method provides a novel scientific basis to study blood
The ISLET project is a multi-center collaboration of leading European researchers that has been awarded 8 million Euros in a 5-year period. The project will develop advanced stem cell products ready for use in clinical trials in Type 1 Diabetes. Professor Henrik Semb from DanStem is coordinating the project. The ISLET project will develop a
Scientists at the University of St Andrews and the University of Edinburgh have identified a specific type of cell in the human body which can cause motor neurons to fail using stem cell technology. The joint research, published today (Monday 16 December) in Glia, has shown that glial cells, which normally support neurons throughout the brain and spinal
In a bid to determine factors linked to the most debilitating forms of multiple sclerosis (MS), Johns Hopkins Medicine researchers say they have identified three so-called “complement system” genes that appear to play a role in MS-caused vision loss. The researchers were able to single out these genes — known to be integral in the
Unique Rice platform helps bioscientists learn how ectoderm cells begin to differentiate Source Rice University During embryonic development, the entire nervous system, the skin and the sensory organs emerge from a single sheet of cells known as the ectoderm. While there have been extensive studies of how this sheet forms all these derivatives, it hasn’t been
Report urges researchers to look outside the petri dish and into the body to study T cell metabolism Source http://www.vai.org/ For years, scientists have used cells grown in petri dishes to study the metabolic processes that fuel the immune system. But a new report in Immunity suggests looking outside the dish and into living organisms gives a
Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early life Source Wellcome Sanger Institute In a world first, scientists have created the human developmental liver cell atlas that provides crucial insights into how the blood and immune systems develop in the foetus. It
Findings reported in The American Journal of Pathology suggest specialized proresolving mediators may become therapeutics that alleviate chronic tendon inflammation Source EurekAlert Tendon tears, both to the rotator cuff and Achilles heel, are common injuries, especially in aged individuals. Painful and disabling, they can adversely impact quality of life. New approaches are required to help
Source Innovation Origins, Lucette Mascini Towards the end of the European Innovation Days, acclaimed scientists advised the European Commission and politicians on what to look out for when funding research with money from the EU’s Horizon Fund (amount: about €100 billion). These grants for scientific research are distributed by the European Research Council from the EU. You don’t have
