Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

The contribution of CD4 + T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. In this paper it’s presented single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4 + T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, were found increased proportions of cytotoxic follicular helper (T FH

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COVID-19 and Heart Failure With Preserved Ejection Fraction

The more common manifestation in the COVID-19 era may be HFpEF related primarily to the unmasking of subclinical HFpEF and secondarily to the development of new HFpEF following infection with SARS-CoV-2. Patients with preexisting cardiovascular disease (CVD) who develop coronavirus disease 2019 (COVID-19) have worse outcomes than patients without CVD.Infection with severe acute respiratory syndrome

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Fewer than 10% of the US adult population formed antibodies against SARS-CoV-2, and fewer than 10% of those with antibodies were diagnosed.

Fewer than 10 percent of the U.S. adult population formed antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first wave of the pandemic, according to a study published online Sept. 25 in The Lancet. Shuchi Anand, M.D., from the Stanford University School of Medicine in Palo Alto, California, and colleagues conducted a cross-sectional

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New randomized clinical trial suggests Hydroxychloroquine failure even as a COVID19 preventative in healthcare workers

In this randomized clinical trial, although limited by early termination, there was no clinical benefit of hydroxychloroquine administered daily for 8 weeks as pre-exposure prophylaxis in hospital-based HCWs exposed to patients with COVID-19. Despite promising early reports and strong in vitro performance, Hydroxychloroquine (HCQ) has become the major therapeutic disappointment of the COVID pandemic. Research

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Safety and efficacy of the Russian COVID-19 vaccine: more information needed for a group of international researchers on The Lancet

Here is reported the content of the Correspondence We read with great interest the results presented by Denis Logunov andcolleagues on the safety and efficacy of a Russian vaccine for COVID-19. Although the study results are potentially significant, we have severalconcerns, which, due to the accelerated distribution of the vaccine to thepopulation, we described in

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Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection

A standard test that assesses variations in red blood cell volume can identify hospitalized patients with COVID-19 who are at elevated risk of becoming critically ill and succumbing to the disease, according to newly published research led by a team of Harvard Medical School investigators at Massachusetts General Hospital’s Center for Systems Biology. The findings, described in JAMA Network

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This week’s Offline column by The Lancet Editor-in-Chief defines Covid-19 Syndemic not Pandemic.

Two categories of disease are interacting within specific populations—infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an array of non-communicable diseases (NCDs). These conditions are clustering within social groups according to patterns of inequality deeply embedded in our societies. The aggregation of these diseases on a background of social and economic disparity exacerbates

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A multicenter cardiovascular pathology study shows various features of COVID-19-associated myocardial injury

Early in the pandemic, other clinicians noted that even some patients who didn’t have preexisting heart conditions experienced cardiovascular damage while fighting COVID-19 infections, pointing to a possible causative link. Researchers had found, for example, that 8–12 percent of hospitalized COVID-19 patients had elevated levels of muscle contraction–regulating proteins called troponins—a sign of heart damage—and that these

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