Source NIH With advances in induced pluripotent stem cell (iPSC) technology, it’s now possible to reprogram adult skin or blood cells to form miniature human organs in a lab dish. While these “organoids” closely mimic the structures of the liver and other vital organs, it’s been tough to get them to represent inflammation, fibrosis, fat
Researchers funded by British Heart Foundation have shown that heart ‘patches’ grown in the lab are safe to move on to trials in people with hearts damaged after a heart attack, in research presented at the British Cardiovascular Society (BCS) Conference in Manchester today. These patches could one day cure debilitating heart failure, which affects
Authors Ghadge Snehal, Aloorkar Nagesh, and Sudake Suresh from the Satara College of Pharmacy explore 3D printing of medication, and the possibilities for the future in ‘A Decisive Overview on Three Dimensional Printing in Pharmaceuticals.’ The researchers realize the enormous impact 3D printing is having worldwide, offering truly infinite power for innovation—with a tremendous focus on the
Source Elsevier One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo. In this important review in Digestive and Liver Disease, published by Elsevier, scientists highlight some of the established and exciting novel uses for organoids or
Expanded Potential Stem Cell lines of pig and human cells established A new approach has enabled researchers to create Expanded Potential Stem Cells (EPSCs) of both pig and human cells. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell. The research
Reviews Gene Editing for Immune Cell Therapies Autologous T cells that have been genetically modified to express a chimeric antigen receptor targeting the B cell antigen CD19 have yielded remarkable clinical responses in patients with B cell malignancies, and are now on the market as anticancer ‘drugs’. [Nat Biotechnol] Abstract The Next Generation of CRISPR-Cas Technologies
MIT startup Inkbit is overcoming traditional constraints to 3-D printing by giving its machines “eyes and brains.” Objects made with 3-D printing can be lighter, stronger, and more complex than those produced through traditional manufacturing methods. But several technical challenges must be overcome before 3-D printing transforms the production of most devices. Commercially available printers
Michigan State University physicians have found that vitamin D, if taken for at least three years, could help cancer patients live longer. The findings suggest that the vitamin carries significant benefits other than just contributing to healthy bones and were presented at the American Society of Clinical Oncology annual meeting on June 3, 2019. In
ZYNTEGLO is the first gene therapy approved for transfusion-dependent β-thalassemia (TDT) European marketing authorization for ZYNTEGLO follows the fastest assessment of an advanced therapy medicinal product (ATMP) as part of the European Medicines Agency’s Priority Medicines (PRIME) program ZYNTEGLO is bluebird bio’s first gene therapy to gain regulatory approval bluebird bio, Inc. announced today that the European Commission (EC)
Source: Nature Study of almost half a million people links mutation that protects against HIV infection to an earlier death. The scientist who edited the genomes of twin girls in an attempt to make them resistant to HIV might have inadvertently shortened their life expectancy. People with two disabled copies of the CCR5 gene — the version
