Cancer study may accidentally help researchers create usable blood stem cells

Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies. Researchers have identified that increasing the expression of the normal form of the MLL gene can drive production of hematopoietic stem cells (HSCs). This not only provides a protocol

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Osaka University team conducts world’s first iPS transplant for corneal disease

A research team from Osaka University said Thursday it had conducted the world’s first transplant of corneal tissues using artificially derived stem cells in July. The university’s team, led by Koji Nishida, may have created a new treatment for those suffering from corneal disease, as current treatment procedures involve waiting for corneal donations from deceased

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Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Since both myocardium and vasculature in the heart are excessively damaged following myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently target both so as to achieve true cardiac repair. Here we demonstrate a concomitant method that exploits the advantages of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) and human mesenchymal

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Road Map for Development of Stem Cell-Based Alternative Test Methods

Researchers of the Institute of Neurophysiology and Centre for Molecular Medicine Cologne (CMMC), University of Cologne (UKK) and Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund (IfADo) have just published a paper in Trends in Molecular Medicine showing that hiPSC differentiation protocols theoretically offer the prospect of an unlimited supply

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Reprogrammed’ stem cells to treat spinal-cord injuries for the first time

Approval from Japanese regulators means that trials of induced pluripotent stem cells can begin later this year. Scientists in Japan now have permission to inject ‘reprogrammed’ stem cells into people with spinal-cord injuries. An upcoming trial will mark the first time that induced pluripotent stem (iPS) cells have been used to treat spinal-cord injuries, after

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