Archives January 2020

UNC Lineberger discovery would allow researchers to fine-tune activity of CAR-T cancer-hunting immune cells

A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease their activity level in the case of severe side effects. In a study published in Cancer Cell, researchers led by UNC Lineberger’s Gianpietro Dotti, MD, reported

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Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Source Cell Metabolism Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, it’s reported that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. Depletion of

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NUS Medicine researchers can now reprogramme cells to revert to original state for regenerative medicine

Inducing totipotency into stem cells outside of embryos will allow maximal cell engineering for therapeutic purposes Early mammalian development is a highly complex process involving elaborate and highly coordinated biological processes. One such process is zygotic genome activation (ZGA) which occurs following the union of the sperm and egg, marking the beginning of life. The

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Penn Researchers Identify Cancer Cell Defect Driving Resistance to CAR T Cell Therapy

Study identifying mechanism that prevents cell death may guide future immunotherapy strategies Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why. In a new study, researchers describe how a

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Stem Cells, CRISPR and Gene Sequencing Technology are Basis of New Brain Cancer Model

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time. “We have developed stem cell models that are CRISPR-engineered to have tumor-associated driver mutations

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University of Melbourne scientists first to grow and share novel coronavirus

Scientists from the Peter Doherty Institute for Infection and Immunity – a joint venture between the University of Melbourne and the Royal Melbourne hospital – have successfully grown the Wuhan coronavirus from a patient sample, which will provide expert international laboratories with crucial information to help combat the virus. This is the first time the virus has

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Buck researchers discover how cellular senescence leads to neurodegeneration

Although a link has been established between chronic inflammation and neurodegenerative diseases, there have been many open questions regarding how cellular senescence, a process whereby cells that stop dividing under stress spew out a mix of inflammatory proteins, affects these pathologies. Publishing in PLOS One, researchers at the Buck Institute report that senescence in astrocytes, the most

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Supporting progress of cell and gene therapy industrialisation with new aseptic manufacturing course

The University of Hertfordshire and the Cell and Gene Therapy Catapult (CGT Catapult) have announced the launch of a new course specifically addressing the foreseeable skills gap in the manufacture of cell and gene therapies as they progress towards manufacturing at scale. Developed in a collaboration between the two organisations, this three-day course will provide

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2019 Novel #Coronavirus (2019-nCoV). New England Journal of Medicine special page

A collection of articles and other resources on the 2019 Novel Coronavirus outbreak, including clinical reports, management guidelines, and commentary. A special page has been created at NEJM.org with a collection of articles and other resources on the 2019 Novel Coronavirus outbreak, including clinical reports, management guidelines, and commentary. NEJM.org/coronavirus   <http://response.nejm.org/t?ctl=585FF:AF09B9D2463988B1A995AADA766177EB961CAA5EB78719DF&>


New gene correction therapy for Duchenne muscular dystrophy. Gene scissors against incurable muscular disease

Duchenne type muscular dystrophy (DMD) is the most common hereditary muscular disease among children, leaving them wheelchair-bound before the age of twelve and reducing life expectancy. Researchers at Technical University of Munich (TUM), Ludwig Maximilian University of Munich (LMU) and the German Research Center for Environmental Health (Helmholtz Zentrum München) have developed a gene therapy

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