Category REGENERATIVE MEDICINE

PIER MARIA FORNASARI
2025-04-13

FDA clears IND for clinical trial testing switchable CAR-T therapy in patients with autoimmune diseases, without chemotherapy

Innovative cellular therapy has potential to treat patients with lupus, systemic sclerosis, myositis and RA without chemotherapy-induced immune suppression. Calibr-Skaggs Institute for Innovative Medicines, the drug discovery division of Scripps Research, announced today that the FDA has cleared their investigational new drug (IND) application to study switchable chimeric antigen receptor T cell (sCAR-T) therapy (CLBR001

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PIER MARIA FORNASARI
2025-04-12

Innovative gene therapy developed to treat a rare and devastating genetic heart disease in young men

A CNIC team has designed a gene therapy-based treatment that could transform the approach to arrhythmogenic cardiomyopathy type 5 (ARVC5), a rare and fatal genetic disease that particularly affects young men. A team from the  National Center for Cardiovascular Research (CNIC) has developed an innovative gene therapy that could transform the treatment of arrhythmogenic cardiomyopathy type 5 (ARVC5),

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No Comments InGENE THERAPY RARE DISEASES
PIER MARIA FORNASARI
2025-04-08

Major advances in the treatment of type 1 diabetes

Recent decades have seen a lot of progress in diabetes treatment. In a new study, Per-Ola Carlsson, Professor of Medical Cell Biology, has obtained promising results. “This is the first time anyone has succeeded in transplanting insulin-producing cells into another individual without immunosuppressive drugs,” he says. The treatment available for type 1 diabetes since the

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No Comments InRESEARCH TISSUE ENGINEERING
PIER MARIA FORNASARI
2025-03-06

Cultured tissue from nasal cartilage cells helps with complicated knee injuries

Damage to joint cartilage is painful and limits mobility. Researchers at the University of Basel and the University Hospital of Basel are therefore developing cartilage implants from cells from the nasal septum. A recent study shows that a longer maturation time for the cultured cartilage brings a significant improvement even in cases of complicated cartilage

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No Comments InCELL THERAPY
PIER MARIA FORNASARI
2025-02-26

Gene therapy in children with AIPL1-associated severe retinal dystrophy can improve vision

Researchers from the NIHR Moorfields Biomedical Research Centre and University College London have found that gene therapy improved visual acuity and preserved retinal structure in young children with AIPL1-associated severe retinal dystrophy. This is the first human trial of gene supplementation therapy targeting this condition. Retinal dystrophy caused by biallelic variants in the AIPL1 gene

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No Comments InGENE THERAPY RARE DISEASES
PIER MARIA FORNASARI
2025-02-01

CAR-T cells can transfer antitumour immunity to other T cells by exchanging surface proteins

Novel research in cells and mice models has provided insight into the mechanisms that regulate trogocytosis, a process during which immune cells can exchange membrane-bound proteins. The study showed that chimeric antigen receptor cells (so-called CAR-T cells) could transfer tumour antigen-specific receptors to recipient T cells, and in doing so equipped the latter cells with tumour-targeting

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PIER MARIA FORNASARI
2025-01-31

Study results open door to heart failure treatment with ‘heart patch’

The heart patch is produced from induced pluripotent stem cells derived heart muscle cells in a collagen hydrogel. Results from rhesus macaques provide solid ground for a first-in-human investigation of heart repair with stem cell-derived engineered heart muscle. The study is a milestone for the clinical application of the ‘heart patch’ as an innovative treatment

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No Comments InREGENERATIVE MEDICINE