Action FDA approved Qalsody (tofersen) to treat patients with amyotrophic lateral sclerosis (ALS) associated with a mutation in the superoxide dismutase 1 (SOD1) gene (SOD1-ALS). Qalsody is an antisense oligonucleotide that targets SOD1 mRNA to reduce the synthesis of SOD1 protein. The approval was based on a reduction in plasma neurofilament light (NfL), a blood-based
Today, the U.S. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic (donor) cord blood-based cell therapy to quicken the recovery of neutrophils (a subset of white blood cells) in the body and reduce the risk of infection. The product is intended for use in adults and pediatric patients 12 years and older
A joint research team of POSTECH, Kyungpook National University, and Korea University Anam Hospital developed an osteogenic barrier coating material that maximizes the effect of guided bone regeneration (GBR) for implant placements. One of the key factors of success in a dental implant is the condition of the periodontium around the implant. A higher long-term
Key Takeaways In people with type 1 diabetes, the body’s immune system attacks and destroys insulin-producing β cells that control blood glucose levels and are part of a group of cells in the pancreas called pancreatic islets. In research published in Cell Reports Medicine, a team led by investigators at Massachusetts General Hospital (MGH), a founding member
A minimally invasive treatment that injects allograft disk tissue into the spine to relieve pain associated with degenerative disk disease provides significant improvement in pain and function over a sustained period, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Phoenix, March 4–9. The treatment, known as viable disk
Understanding how the knee joint environment affects cartilage cells is crucial for joint health. Knowledge of cell-driven cartilage degeneration mechanisms can support the development of effective pharmaceutical interventions for osteoarthritis. The burden of musculoskeletal diseases, such as osteoarthritis, is increasingly affecting patients’ quality of life and bringing enormous costs to health care. In efforts to
New Cell Therapy Offers Potential Treatment Option for Patients With Chronic Heart Failure Physician-scientists at The Texas Heart Institute announced today the results of the largest cell therapy trial to date in patients with chronic heart failure due to low ejection fraction. The therapy benefited patients by improving the heart’s pumping ability, as measured by
A team of medical specialists working at Memorial Sloan Kettering Cancer Center in New York has found that donated white blood cells can be used effectively as part of CAR T cell therapy to treat myeloma patients. In their study, published in the journal Nature Medicine, the group gave patients varying amounts of donated CAR T cells
A new blood product combining red blood cells and plasma in one bag is associated with a better survival from a penetrating major trauma injury, a new study involving Queen Mary University of London has found. NHS Blood and Transplant, Queen Mary University London, and Barts Health NHS Trust collaborated on the new study published in
Blocking an immune-regulating protein reverses the damage caused by acute and chronic kidney disease, a preclinical study suggests. Led by scientists at Duke-NUS Medical School and the National Heart Centre Singapore, researchers in Singapore and Germany have found that renal tubular cells, which line the tiny tubes inside kidneys, release a scar-regulating protein called interleukin-11
