Rebyota Approved for the Prevention of Recurrence of Clostridioides difficile Infection in Adults Today, the U.S. Food and Drug Administration approved Rebyota, the first fecal microbiota product approved by the agency. Rebyota is approved for the prevention of recurrence of Clostridioides difficile infection (CDI) in individuals 18 years of age and older. It is for use after
The brain is uniquely protected against invading bacteria and viruses, but its defence mechanism has long remained a mystery. Now, a study in mice, confirmed in human samples, has shown that the brain has a surprising ally in its protection: the gut. Source University of Cambridge The brain is arguably the most important organ in
An international team led by scientists from Memorial Sloan Kettering has shown for the first time that foods containing lactose, a sugar that’s naturally found in milk and dairy products, help Enterococcus thrive in the gut, at least in mice. Infections with the Enterococcus bacterium are a major threat in healthcare settings. They can lead to inflammation
Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on specific bacteria. Published today in Nature Communications, this study opens up the possibility of using CRISPR to alter the makeup of the human microbiome in a way that could be personalized
Dogs with a Crohn’s-like disease fed a special diet were found to have characteristic changes in their gut microbiomes, paralleling changes seen in children with Crohn’s. uch remains mysterious about the factors influencing human inflammatory bowel disease (IBD), but one aspect that has emerged as a key contributor is the gut microbiome, the collection of
Source NIH The normal human gut microbiome is a flourishing community of microorganisms, some of which can affect the human immune system. In a new paper published this week in Cell, researchers found that oral antibiotics, which can kill gut microorganisms, can alter the human immune response to seasonal influenza vaccination. The work was led by
Researchers identify nearly 8,000 strains of bacteria, while also clarifying their genetic and metabolic context. The human digestive tract is home to thousands of different strains of bacteria. Many of these are beneficial, while others contribute to health problems such as inflammatory bowel disease. Researchers from MIT and the Broad Institute have now isolated and
A Novel Hypothesis: The Microbiota–Gut–Brain Axis The two most common neurodegenerative disorders have a very long history. The first reported case of Alzheimer’s disease (AD) was in 1906, while Parkinson’s disease (PD) was described in 1817. Since then, intensive research has provided plenty of clinical, genetic, and molecular evidence of AD and PD signs, mechanisms,
Source Wyss Institute for Biologically Inspired Engineering at Harvard The human microbiome, the huge collection of microbes that live inside and on our body, profoundly affects human health and disease. The human gut flora in particular, which harbor the densest number of microbes, not only break down nutrients and release molecules important for our survival
Experiments in mice show transmission of nerve-killing protein from the gut into the brain In experiments in mice, Johns Hopkins Medicine researchers say they have found additional evidence that Parkinson’s disease originates among cells in the gut and travels up the body’s neurons to the brain. The study, described in the June issue of the
