Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides novel insights into the mechanisms that regulate brain blood flow and highlight a potential therapeutic strategy to correct vascular dysfunction. Their preclinical findings, published December 22 in Proceedings of the National Academy of Sciences, suggest that adding a missing phospholipid back into a
According to a new announcement, the FDA has given clearance to Roche’s Elecsys ptau181 test, marking it the first blood-based biomarker test available for use in primary care settings to assist in Alzheimer disease (AD) assessment and diagnosis. Through this minimally invasive test, clinicians may better identify patients in early stages of cognitive decline who
The growth factor erythropoietin (EPO), known from haematopoiesis, also has important effects in the brain, particularly for learning and thought processes. The findings offer new perspectives for therapies. In the brain, it is not only important that nerve cells send signals, but also how quickly they can do so. In order for information to flow
Researchers at Case Western Reserve School of Medicine have found that, when compared to seven other anti-diabetic drugs, semaglutide, a popular diabetes and weight-loss drug, may lower the risk of Alzheimer’s disease in people with type 2 diabetes (T2D). Alzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills. According to the Alzheimer’s Association, nearly
A novel new therapy has been found to reduce harmful plaque in arteries and change its composition so it is less likely to rupture and cause a heart attack, following a clinical trial led by the Victorian Heart Institute (VHI) at Monash University. The HUYGENS study treated high-risk patients over a 12 month period and
Researchers at Albany Medical College in New York have discovered that a specific type of immune cell accumulates in older brains, and that activating these cells improves the memory of aged mice. The study, which has been published February 5 in the Journal of Experimental Medicine (JEM), suggests that targeting these cells might reduce age-related cognitive decline
Source Cell Metabolism Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, it’s reported that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. Depletion of
Discoveries Could One Day Lead to New Drugs to Prolong Healthy Human Lifespan The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could
In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics”. The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. This trial —
Tokyo Medical and Dental University(TMDU)-led study published in Nature shows that epidermal stem cells in the skin compete with each other to eliminate stressed, unfit cells; this maintains skin youthfulness, but with time also causes the skin to age. Aging is a process that results from the accumulation of damage due to failed repair and
