Category HORIZON 2020 PROJECTS

Special delivery: McMaster physicists design ‘super-human’ red blood cells to deliver drugs to specific targets within the body

A team of physicists from McMaster University has developed a process to modify red blood cells so they can be used to distribute drugs throughout the body, which could specifically target infections or treat catastrophic diseases such as cancer or Alzheimer’s. The modified red blood cells are designed to circulate in the body for several

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New Microscopy Technique Shows Cells’ 3-D Ultrastructure in New Detail

The method melds the best of super-resolution fluorescence and electron microscopy to show how proteins relate to cells’ fine structure. Inside a cell, tentacled vesicles shuttle cargo for sorting. Neighboring neurons cling to one another through a web-like interface. DNA rearranges in the nucleus as stem cells differentiate into neurons. And a new microscopy technique

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Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

iPSC-based drug discovery is a promising technology for developing novel therapeutics for neurodegenerative diseases lacking useful disease models, such as amyotrophic lateral sclerosis (ALS). Ropinirole, retigabine, and bosutinib were identified as candidate therapeutic agents for ALS by the combination of iPSC-based drug discovery and drug repositioning. The potential anti-ALS mechanism of ropinirole is independent of

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Researchers create ‘artificial cartilage’ that can repair itself

New hydrogel made from forestry and fishing waste could help replace petroleum-based products from contact lenses to pill capsules. A new hydrogel material created from materials typically discarded by the forest and fishing industries could be a substitute for petroleum products used in a variety of biomedical applications, from contact lenses to pill capsules. “The

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New multiple sclerosis treatment trial compares stem cell transplantation to best available drugs

NIH-funded study focuses on severe forms of relapsing MS. Source NIH A clinical has begun trial testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis (MS). The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of

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Breakthrough study on molecular interactions could improve development of new medicines

A first-of-its-kind study on molecular interactions by biomedical engineers in the University of Minnesota’s College of Science and Engineering will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV and autoimmune diseases. The study resulted in a mathematical framework that simulates the effects

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Alzheimer ‘Tau’ Protein Far Surpasses Amyloid in Predicting Toll on Brain Tissue

Tau PET Brain Imaging Could Launch Precision Medicine Era for Alzheimer’s Disease Brain imaging of pathological tau-protein “tangles” reliably predicts the location of future brain atrophy in Alzheimer’s patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center. In contrast, the location of

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Hematopoietic stem cell marker: A key player in the ontogeny of hematopoiesis

A group of researchers at Osaka University revealed that endothelial cell-selective adhesion molecule (ESAM), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis. Their research results were published in Stem Cell Reports. In hematopoiesis,

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