CRISPR – REGENHEALTHSOLUTIONS (RHS)

PIER MARIA FORNASARI
2022-05-12

Novel Supramolecular CRISPR–Cas9 Carrier Enables More Efficient Genome Editing

Fifth generation polyrotaxane (PRX) carriers can effectively deliver CRISPR-Cas9 ribonucleoproteins (RNPs) The PRX carrier can cross the cell membrane, avoid endosomal action, and release Cas9 RNP for entry into the nucleusImage courtesy: Kumamoto University, The carriers, aminated polyrotaxanes, can flexibly and reversibly bind with Cas9 ribonucleoprotein and protect it from intracellular endosomal degradation CRISPR-Cas9 is

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PIER MARIA FORNASARI
2020-03-06

Scientists at Oregon edit genes inside the body using CRISPR for a hereditary blindness disorder, in a trial called BRILLIANCE.

A person with a genetic condition that causes blindness has become the first to receive a CRISPR–Cas9 gene therapy administered directly into their body. The treatment is part of a landmark clinical trial to test the ability of CRISPR–Cas9 gene-editing techniques to remove mutations that cause a rare condition called Leber’s congenital amaurosis 10 (LCA10).

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PIER MARIA FORNASARI
2020-02-07

CRISPR-Edited Cells for Cancer Therapy Safe in Humans: Trial published on Science

In the first clinical study of its kind in the US, researchers used CRISPR to modify CAR T cells to make them more potent against cancer, but the clinical benefits are unknown. mmune cells altered by CRISPR are safe to use in cancer patients, according to results of a clinical trial reported February 6 in Science.

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PIER MARIA FORNASARI
2020-01-03

Strategies for the CRISPR-Based Therapeutics

The CRISPR (clustered regularly interspaced short palindromic repeats)-based genome editing technology is an emerging RNA-guided nuclease system initially identified from the microbial adaptive immune systems. In recent years, the CRISPR system has been reprogrammed to target specific regions of the eukaryotic genome and has become a powerful tool for genetic engineering. Researchers have explored many

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PIER MARIA FORNASARI
2020-01-02

Will Prime Editors be the New CRISPR?

Early results suggest that prime editors are cleaner than CRISPR–Cas9 and more versatile than base editors, but many questions remain. A paper recently published in Nature from David Liu and co-workers discloses a ‘prime’ gene-editing system many years in the making. In principle, the system, comprising a catalytically impaired Cas9 enzyme and an engineered reverse transcriptase, may

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PIER MARIA FORNASARI
2019-10-29

Twitter reveals growing global public anxiety about Crispr gene-editing

The first ever analysis of all the tweets discussing Crispr gene-editing has revealed how the public feels about the technology. The findings suggest that over a six years public approval of gene-editing has cooled and that most people chatting about the technology are worried. Twitter offers researchers a vast amount of semi-structured data and provides direct access

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PIER MARIA FORNASARI
2019-10-23

Search-and-replace genome editing without double-strand breaks or donor DNA

Gene editing to correct genetic faults and removing the risk of hereditary diseases may soon become reality. Researchers have come up with a new gene editing technology that could help patients with sickle cell anaemia and up 89 percent of other genetic defects. This new technique is called the “prime editing” and is being developed

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PIER MARIA FORNASARI
2019-10-14

Don’t change your DNA at home, says America’s first CRISPR law

A California “human biohacking” bill calls for warnings on do-it-yourself genetic-engineering kits. Source Technology Review It’s going to be illegal in California to sell “gene-therapy kits” unless they carry a warning that says not to use them on yourself. Just one wrinkle: we’re not sure any such kit exists. Not yet, anyway. The consumer protection

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PIER MARIA FORNASARI
2019-10-11

New articles on the ethics of genome editing published in The CRISPR Journal

Source http://www.liebertpub.com/ The CRISPR Journal announces the publication of its October 2019 Special Issue on The Ethics of Human Genome Editing. The Journal is led by Editor-in-Chief Rodolphe Barrangou, PhD (North Carolina State University) and Executive Editor Dr. Kevin Davies. For full-text copies of articles or to arrange interviews with Dr. Barrangou, Dr. Davies, authors, or

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PIER MARIA FORNASARI
2019-10-03

Exploring the Latest in CRISPR and Stem Cell Research

Source Technologynetworks Since the gene-editing potential of CRISPR systems was realized in 2013, they have been utilized in laboratories across the world for a wide variety of applications. When this gene-editing power is harnessed with the proliferative potential of stem cells, scientists level up their understanding of cell biology, human genetics and the future potential

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Category CRISPR

Novel Supramolecular CRISPR–Cas9 Carrier Enables More Efficient Genome Editing

Scientists at Oregon edit genes inside the body using CRISPR for a hereditary blindness disorder, in a trial called BRILLIANCE.

CRISPR-Edited Cells for Cancer Therapy Safe in Humans: Trial published on Science

Strategies for the CRISPR-Based Therapeutics

Will Prime Editors be the New CRISPR?

Twitter reveals growing global public anxiety about Crispr gene-editing

Search-and-replace genome editing without double-strand breaks or donor DNA

Don’t change your DNA at home, says America’s first CRISPR law

New articles on the ethics of genome editing published in The CRISPR Journal

Exploring the Latest in CRISPR and Stem Cell Research