Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University’s Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children’s Hospital of Philadelphia (CHOP), the University of Pennsylvania, and the Valley

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Could a viral illness increase chances of developing Alzheimer’s or other neurodegenerative disease?

NIH biobank study suggests vaccinations against viruses may also reduce risk of neurological disorders Some viral illnesses may increase a person’s chances of later developing Alzheimer’s disease or another neurodegenerative disorder. Though a causal link cannot be confirmed, an NIH study in which researchers mined the medical records of hundreds of thousands of people in

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Cleveland Researchers Discover New Oral Drug for Lowering Cholesterol

Study led by University Hospitals and Case Western Reserve University team details a small-molecule drug that lowers cholesterol by 70% in animal models –After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are

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Glucose metabolites, rather than glucose itself, have been discovered to be key to the progression of type 2 diabetes.

Oxford Research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes.  In diabetes, the pancreatic beta-cells do not release enough of the hormone insulin, which lowers blood glucose levels. This is because a glucose metabolite damages pancreatic beta-cell function. An estimated 415 million people globally are living with diabetes. With nearly 5

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Technion researchers have developed a technology to measure the long-term effect of antibiotic “combination therapies”

Researchers at the Technion have developed a technology to measure the long-term effect of antibiotic combinations (cocktails). These combinations are of concern to the scientific and medical community due to the fact that the use of single antibiotics often leads to the rapid development of bacterial resistance to antibiotics. The research published in Nature was led by Technion

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Intravenous iron improved long-term outcomes for people with heart failure and iron deficiency

Research Highlights: Repeated intravenous (IV) administration of iron reduced the risk of hospitalization for heart failure and cardiovascular death in people with heart failure and iron deficiency, according to a clinical trial in the United Kingdom. Treatment with IV iron was safe and well-tolerated, and people who received it reported improved well-being based on quality-of-life

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Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

 New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) found that different skeletal stem cell (SSC) populations contribute to repair of different kinds of bone injuries. In the study, published in Cell Stem Cell, researchers identified distinct cell markers that allowed them to track SSCs in the bone marrow inside of bones versus SSCs in the

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Colonoscopy unfortunately is not a miracle cure for colorectal cancer. According to study published inNEJM is not better than the fecal samples

On October 10 the world’s first randomized study on using colonoscopy-screening to prevent colorectal cancer was presented during the 2022 United European Gastroenterology Week in Vienna. The full study was also published in New England Journal of Medicine. “Colonoscopy unfortunately is not a miracle cure for colorectal cancer. According to our study, it probably is not better

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Scientists identify WASH protein complex as a gatekeeper of neutrophil-driven inflammation

A team led by Scripps Research scientists has uncovered key details of an immune-cell process that frequently underlies excessive inflammation in the body. The findings could lead to new ways of preventing and/or treating inflammation-related conditions such as sepsis, arthritis, and coronary artery disease. In the study, published September 21, 2022 in Nature Communications, the researchers

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