Risk thresholds for kidney disease confirmed by more precise measurements

The kidney function thresholds currently used to diagnose chronic kidney disease reflect an actual increase in the risk of serious disease, according to a study from Karolinska Institutet and Leiden University Medical Center published in the journal JAMA. The researchers also show that risk assessment becomes more accurate when two common blood tests, creatinine and

Read More


Gene Expression ‘Clocks’ Reveal Shared Molecular Signatures of Aging and Mortality Across Mammals

Mass General Brigham researchers identify conserved gene expression signatures linked to biological aging and risk of disease and mortality, offering a new framework for quantifying aging and evaluating interventions that modulate healthspan and lifespan A team led by investigators at Mass General Brigham has discovered that different tissues in humans and other mammals share common gene expression

Read More


Oral Medication Proves Effective for Low Platelets Due to Chemotherapy

Summary The oral medication avatrombopag proved highly effective against chemotherapy-induced thrombocytopenia (CIT) in a phase 2 clinical trial of patients with gastrointestinal cancers. CIT is a major burden in cancer treatment and can cause treatment delays that significantly impact patients’ outcomes. The senior author of the study is Sylvester’s chief of the classical hematology service,

Read More


NIH Researchers develop innovative model for risk assessment for hypertrophic cardiomyopathy

NIH-funded study incorporates new measures to better predict outcomes in chronic heart condition. Findings from a study supported in part by the National Institutes of Health (NIH) have identified a new model for predicting outcomes for hypertrophic cardiomyopathy (HCM), a heart condition with a prevalence of 1 in 500 people and a frequent cause of

Read More


AI-powered electrocardiogram detects early signs of heart failure

UT South Western-led Kenya study suggests relatively inexpensive technology could reduce cardiac health disparities in developing countries Interpreting relatively inexpensive electrocardiograms (ECGs) with an artificial intelligence (AI) algorithm accurately screened patients for a key precursor of heart failure in Kenya, a study led by UT Southwestern Medical Center researchers shows. The results, published in JAMA Cardiology, suggest

Read More


Blood stem cells evade immunity in aplastic anemia by similar genetic mutations arising independently

A genomic study of the largest pediatric and adult aplastic anemia cohort genetically profiled to date, finds that protective mutations arise as independent events in different stem cells years before diagnosis. Aplastic anemia is a rare, life-threatening blood disorder where patients are unable to make enough blood cells due to the immune system’s attack on

Read More


Umbilical cord blood transplant with pooled stem cell product shows 96% survival and no graft-versus-host-disease in leukemia patients

A phase 2 study published in the Journal of Clinical Oncology shows that a stem cell product called dilanubicel safely enabled umbilical cord blood transplants in 28 patients A new way of using umbilical cord blood for treating blood diseases could make the treatment more accessible to patients who need a stem cell transplant. A

Read More