Phase I trial published in Nature: China’s novel base-editing therapy brings hope of cure for thalassemia patients

In a breakthrough for gene therapy, the international academic journal Nature has published a landmark clinical study detailing the successful use of a novel base-editing drug to treat β-thalassemia. Jointly conducted by ShanghaiTech University, the First Affiliated Hospital of Guangxi Medical University, Fudan University, and CorrectSequence Therapeutics, the early-stage clinical trial of the base-editing drug CS-101 injection reports that

Read More


Surviving sepsis: New guidelines harness life saving evidence for treating adults

Updated recommendations include critical insights from research An international team of experts recently came together to update sepsis care guidelines for adults for the first time since 2021. The updates have profound implications for the management of sepsis, which is responsible for approximately 11 million deaths per year worldwide. Co-led by University of Michigan’s Hallie Prescott, M.D.,

Read More


Long Dismissed in Adult Health, the Thymus May Be Critical for Longevity and Cancer Treatment

Mass General Brigham researchers used artificial intelligence to analyze routine medical scans, uncovering how the thymus impacts aging, cardiovascular risk, cancer incidence, and response to immunotherapy. Two new studies from investigators at Mass General Brigham challenge a decades-old assumption that the thymus, an organ best known for its role in establishing immune function in childhood, becomes irrelevant

Read More


Study: Electrical stimulation can restore ability to move limbs, receive sensory feedback after spinal cord injury

In new results from a clinical trial, researchers show that electrical stimulation of the spinal cord can restore the muscle control and sensory feedback required for coordinated walking movements. The effects of spinal cord injuries are complex and multifaceted. People lose not only the ability to control the movement of their limbs, but also the

Read More


Researchers develop beating, 3D‑printed heart model for surgical practice

Washington State University researchers have developed a 3D-printed model of the left side of the heart that contracts and beats, offering the chance for surgeons and medical students to rehearse important heart surgeries on a model that acts like the real thing. The WSU researchers, in fact, did a valve repair on their heart model, using ultrasound imaging

Read More


From Longevity to Cancer: Understanding the Dual Nature of Polyamines

Study reveals how the same molecules that promote healthy aging can fuel cancer growth through distinct molecular pathways Polyamines, a group of naturally occurring molecules found in all living organisms, are essential for fundamental cellular processes, such as growth and differentiation. In recent years, these compounds (particularly spermidine) have gained attention as promising ‘geroprotectors’ that

Read More