Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial shows reduction risk of heart failure hospitalizations.

1. Treatment with IV ferric carboxymaltose reduced the risk of heart failure hospitalizations in patients with iron deficiency and acute heart failure with a left ventricular ejection fraction less than 50%. 2. IV ferric carboxymaltose was generally safe but had no significant effect on the risk of cardiovascular death compared to placebo. Evidence Rating Level: 1

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Research advances understanding of life-threatening lung inflammation following the flu

Preclinical studies are underway at St. Jude Children’s Research Hospital to develop small molecule inhibitors to prevent deadly inflammation and lung damage following respiratory infections and asthma. St. Jude Children’s Research Hospital scientists have identified fibroblasts as the cells that serve as the gatekeeper of the inflammatory immune response in the lungs following influenza and other respiratory infections.

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JAMA Drug Pricing Issue: Pharma’s Outsized Profits and Lobbying Spend

In a presidential election year where the high cost of prescription drugs has been a major campaign issue, JAMA joined the fray with a special issue on drug pricing. Source MEDPAGETODAY Four studies — three in JAMA and one in JAMA Internal Medicine — along with a handful of editorials dig deeper into key questions about the U.S. pharmaceutical industry: Is

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A Fundamental Discovery About How Gene Activity Is Regulated

Researchers at Johns Hopkins Bloomberg School of Public Health have discovered a fundamental mechanism that regulates gene activity in cells. The newly discovered mechanism targets RNA, or ribonucleic acid, a close cousin of DNA that plays an important role in cellular activity. The discovery, detailed in a paper published February 3 in the journal Molecular Cell, is a

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R&D plans are the stars in new EU industrial strategy and “Wholly Inclusive” European Research Area

A draft plan, for adoption in Brussels on 4 March, highlights the importance of research and innovation in making EU industry more competitive Source Science Business The new European Commission is putting research and innovation at the heart of its ambitious new industrial strategy. A draft memo on the strategy, dated 14 January, for a

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Elsevier puts together free resource on coronavirus

Elsevier has set up an Information Centre on the newly emerged coronavirus featuring in the current outbreak in China, with free information in English and Mandarin. The resource is intended to help healthcare professionals, medical researchers and the public, bringing together content from Elsevier’s medical journals, textbooks and clinical experts, alongside resources from other information providers and

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