Glaucoma remains one of the most common causes of vision loss and blindness in the U.S. and much of the world, disproportionately affecting older people, African Americans, and Hispanics and Latinos. Early signs of glaucoma can vary, from eye pressure to changes in the appearance of the optic nerve, and the disease can progress for
Researchers at the University of Leicester have discovered the mechanism by which cholesterol in our diet is absorbed into our cells. This discovery, which has just been published in the journal Science opens up new opportunities for therapeutic intervention to control cholesterol uptake that could complement other therapies and potentially save lives. The research, conducted with colleagues
Gait impairment can be a significant challenge as Parkinson’s disease (PD) advances, with balance problems, frequent falls, and freezing of gait impeding quality of life. Often these challenges do not respond to increased amounts of PD medication or deep brain stimulation (DBS). In recent years, electrical stimulation of the spinal cord has been a research
A study published in the New England Journal of Medicine has shown that there may finally be an alternative to amputation for patients suffering from chronic limb-threatening ischemia (CLTI), the most severe form of peripheral artery disease. This study, co-led by University Hospitals (UH) Harrington Heart & Vascular Institute, could lead to the first FDA approval of
For most people, getting burrs stuck to your clothes during a hike is nothing more than a nuisance, something to pick off and throw out when you get home. But for scientists at the Center for Engineering MechanoBiology (CEMB), the hooks on these little hitchhikers are inspiring new suturing schemes for surgical reattachment of tendon to
A clinical study at Karolinska Institutet and Karolinska University Hospital shows that the hunger hormone ghrelin can increase the heart’s pumping capacity in heart failure. The results have been published in the European Heart Journal. Around 200,000 Swedes are estimated to live with heart failure, which is a condition where the heart’s pumping ability is impaired,
Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University’s Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children’s Hospital of Philadelphia (CHOP), the University of Pennsylvania, and the Valley
NIH biobank study suggests vaccinations against viruses may also reduce risk of neurological disorders Some viral illnesses may increase a person’s chances of later developing Alzheimer’s disease or another neurodegenerative disorder. Though a causal link cannot be confirmed, an NIH study in which researchers mined the medical records of hundreds of thousands of people in
Study led by University Hospitals and Case Western Reserve University team details a small-molecule drug that lowers cholesterol by 70% in animal models –After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are
Oxford Research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. In diabetes, the pancreatic beta-cells do not release enough of the hormone insulin, which lowers blood glucose levels. This is because a glucose metabolite damages pancreatic beta-cell function. An estimated 415 million people globally are living with diabetes. With nearly 5
