A study published in the New England Journal of Medicine has shown that there may finally be an alternative to amputation for patients suffering from chronic limb-threatening ischemia (CLTI), the most severe form of peripheral artery disease. This study, co-led by University Hospitals (UH) Harrington Heart & Vascular Institute, could lead to the first FDA approval of
For most people, getting burrs stuck to your clothes during a hike is nothing more than a nuisance, something to pick off and throw out when you get home. But for scientists at the Center for Engineering MechanoBiology (CEMB), the hooks on these little hitchhikers are inspiring new suturing schemes for surgical reattachment of tendon to
A clinical study at Karolinska Institutet and Karolinska University Hospital shows that the hunger hormone ghrelin can increase the heart’s pumping capacity in heart failure. The results have been published in the European Heart Journal. Around 200,000 Swedes are estimated to live with heart failure, which is a condition where the heart’s pumping ability is impaired,
Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University’s Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children’s Hospital of Philadelphia (CHOP), the University of Pennsylvania, and the Valley
NIH biobank study suggests vaccinations against viruses may also reduce risk of neurological disorders Some viral illnesses may increase a person’s chances of later developing Alzheimer’s disease or another neurodegenerative disorder. Though a causal link cannot be confirmed, an NIH study in which researchers mined the medical records of hundreds of thousands of people in
Study led by University Hospitals and Case Western Reserve University team details a small-molecule drug that lowers cholesterol by 70% in animal models –After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are
Oxford Research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. In diabetes, the pancreatic beta-cells do not release enough of the hormone insulin, which lowers blood glucose levels. This is because a glucose metabolite damages pancreatic beta-cell function. An estimated 415 million people globally are living with diabetes. With nearly 5
Researchers at the Technion have developed a technology to measure the long-term effect of antibiotic combinations (cocktails). These combinations are of concern to the scientific and medical community due to the fact that the use of single antibiotics often leads to the rapid development of bacterial resistance to antibiotics. The research published in Nature was led by Technion
Research Highlights: Repeated intravenous (IV) administration of iron reduced the risk of hospitalization for heart failure and cardiovascular death in people with heart failure and iron deficiency, according to a clinical trial in the United Kingdom. Treatment with IV iron was safe and well-tolerated, and people who received it reported improved well-being based on quality-of-life
New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) found that different skeletal stem cell (SSC) populations contribute to repair of different kinds of bone injuries. In the study, published in Cell Stem Cell, researchers identified distinct cell markers that allowed them to track SSCs in the bone marrow inside of bones versus SSCs in the
