Recommendations for calcium and vitamin D supplementation should be re-evaluated, suggest researchers Calcium, vitamin D, or combined supplements offer little to no clinically meaningful benefit on fracture and fall prevention in most older people, finds an in-depth review of the latest evidence published by The BMJ . Almost a third of people aged 65 and older fall each year,
Low back pain affects around 619 million people worldwide, but a new review suggests many are receiving unnecessary scans and ineffectual treatments. Researchers compiled latest evidence from hundreds of studies to provide clinicians with an up-to-date guide to assist with assessment and management, with “Low Back Pain: A Review” published in JAMA. Professor James McAuley and Dr Aidan Cashin
Researchers developed an innovative therapy that reduces nerve cell damage after spinal cord injury and restored up to 80% of motor function in animal models A new study led by Tel Aviv University offers real hope to millions worldwide affected by spinal cord injury (SCI), a devastating condition in which damage continues to spread after
The kidney function thresholds currently used to diagnose chronic kidney disease reflect an actual increase in the risk of serious disease, according to a study from Karolinska Institutet and Leiden University Medical Center published in the journal JAMA. The researchers also show that risk assessment becomes more accurate when two common blood tests, creatinine and
At the ASCO annual meeting, Dana-Farber’s Brian Wolpin, MD, MPH, will present positive results from the RASolute 302 trial showing a substantial prolongation of survival for patients with previously treated metastatic pancreatic cancer, regardless of RAS mutation status, taking daraxonrasib, an investigational oral RAS(ON) multi-selective inhibitor, compared with chemotherapy. A shift in the way people
Mass General Brigham researchers identify conserved gene expression signatures linked to biological aging and risk of disease and mortality, offering a new framework for quantifying aging and evaluating interventions that modulate healthspan and lifespan A team led by investigators at Mass General Brigham has discovered that different tissues in humans and other mammals share common gene expression
The interim Phase I trial data was only from 35 people, but results look good so far. An experimental gene-editing therapy that aims to lower bad cholesterol for the long-term after a single infusion is off to a positive start in an early clinical trial. Researchers running a Phase I safety trial for the drug,
Sitting for More Than 10 Hours a Day Doubles Risk. Need to Increase Walking and Low-Intensity Activities A study has found that the longer a woman spends sitting during pregnancy, the greater the risk of health issues related to pregnancy and childbirth, such as gestational hypertension or premature birth, while conversely, increasing light physical activity
Researchers are testing CAR T cell therapy as a way to reset the immune system in lupus, Graves’ disease and other conditions where the body’s defenses go rogue At age 49, Jan Janisch-Hanzlik’s multiple sclerosis was destroying her freedom to live the life she wanted. She gave up her active nursing job for a desk
Summary The oral medication avatrombopag proved highly effective against chemotherapy-induced thrombocytopenia (CIT) in a phase 2 clinical trial of patients with gastrointestinal cancers. CIT is a major burden in cancer treatment and can cause treatment delays that significantly impact patients’ outcomes. The senior author of the study is Sylvester’s chief of the classical hematology service,
