Pfizer and BioNTech will begin trials of their updated mRNA Covid-19 vaccine designed to protect against the newer BA.4 and BA.5 sub-variants of the coronavirus latest this month, BioNTech announced on Monday, joining other vaccine makers like Moderna who are trying to create updated shots targeting the faster spreading and immune evasive variants. The trial
Results published by University of Leuven researchers in eBioMedicine Markers of inflammation and coagulation are predictors for clinical outcomes in patients with COVID-19. Binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the angiotensin converting enzyme 2 receptor, which is involved in kinin breakdown, could interfere with the kallikrein-kinin pathway. SARS-CoV-2 induced dysregulation
One in eight adults (12.7%) who are infected with SARS-CoV-2 experience long term symptoms due to COVID-19, suggests a large Dutch study published in The Lancet. The study provides one of the first comparisons of long-term symptoms after SARS-CoV-2 infection (often called ‘long COVID’) with symptoms in an uninfected population, as well as measuring symptoms in
Scientists at St. Jude Children’s Research Hospital developed a simple method to select for more effective cancer-destroying CAR T cells for patients with relapsed T-ALL. Scientists at St. Jude Children’s Research Hospital are improving chimeric antigen receptor (CAR) T-cell therapy. Their new simplified approach selected for an advantageous T-cell type and showed promise in the lab against relapsed T-cell
In rodent models, introduced neuroprotective protein slowed disease progression and increased life span Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control. In a new study, published July 11, 2022 in the journal Theranostics, researchers at
A multi-institutional effort led by researchers at the School of Veterinary Medicine is taking steps to develop an effective technique to regenerate photoreceptors cells and restore sight in people with vision disorders. What if, in people with blinding retinal disorders, one could simply introduce into the retina healthy photoreceptor cells derived in a dish from
Doubling to quadrupling the minimum amount of weekly physical activity recommended for U.S. adults may substantially lower the risk of dying from cardiovascular disease and other causes, new research finds. The study, published Monday in the American Heart Association journal Circulation, found people who followed the minimum guidelines for moderate or vigorous long-term, leisure physical activity
More research suggests it’s time to abandon the craze over vitamin D. Taking high doses of “the sunshine vitamin” doesn’t reduce the risk of broken bones in generally healthy older Americans, researchers reported Wednesday on NEJM . It’s the latest in a string of disappointments about a nutrient once hoped to have wide-ranging protective effects. That same
About 5% of adults may develop long-lasting changes to their sense of smell or taste after COVID-19 infection, suggests research published by The BMJ today. With more than 550 million confirmed COVID-19 cases to date, this means that at least 15 million and 12 million adult patients may experience long-term smell and taste deficiencies, respectively. Given the
Interdisciplinary team of researchers from UMass Amherst and UMass Chan Medical School maps the cellular production of protein and discovers how to boost its output In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass
