Investigational daily pill lowered LDL cholesterol as much as injectables

Research Highlights: Among people with a previous heart attack or stroke, or who are at high risk for one, a daily oral medication may offer an effective alternative to injections of PCSK9 inhibitors to lower low-density lipoprotein (LDL or “bad” cholesterol), according to a preliminary late-breaking science presentation today at the American Heart Association’s Scientific Sessions 2025. The meeting, Nov.

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New 2025 Guidelines for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

Preventing and managing high blood pressure with healthy lifestyle behaviors, such as following a heart-healthy diet including reducing salt intake, staying physically active, maintaining a healthy weight and managing stress—combined with early treatment with medication to lower blood pressure if necessary—are recommended to reduce the risk of heart attack, stroke, heart failure, kidney disease, cognitive

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A Specific Human Gene Can Help the Heart Repair Itself From Heart Attack or Heart Failure

First-ever discovery by Hina Chaudhry, MD of Mount Sinai could lead to new and less invasive treatments A naturally occurring gene called Cyclin A2 (CCNA2), which turns off after birth in humans, can actually make new, functioning heart cells and help the heart repair itself from injury including a heart attack or heart failure when

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Short and long-term risks of vascular and inflammatory diseases following first COVID-19 diagnosis and vaccination in children and young people.

A new study shows children and young people face long-lasting and higher risks of rare heart and inflammatory complications after COVID-19 infection, compared to before or without an infection. Meanwhile, the COVID-19 vaccination was only linked to a short-term higher risk of myocarditis and pericarditis. The study is the largest of its kind in this

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Even Modest Amounts of Physical Activity May Slow Alzheimer’s Disease Among At-Risk Older Adults

Increasing your steps by even a little bit may help slow down the progression of Alzheimer’s disease among people at heightened risk, according to a new study. In a paper published in Nature Medicine, Mass General Brigham researchers found that physical activity was associated with slower rates of cognitive decline in older adults with elevated levels of

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Simple saliva test could revolutionise heart failure detection

Detecting acute heart failure in the future could be as simple as testing a  saliva sample. Australian scientists have developed a biosensor that can rapidly detect the heart failure biomarker S100A7 in saliva,  offering a simple, non-invasive way to identify the disease. The breakthrough, published in Biosensors and Bioelectronics: X could make heart failure screening more accessible,

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Novel Sirolimus-Eluting Balloon Appears Noninferior to Conventional Therapies for Treatment of In-stent Restenosis

Trial led by Mount Sinai researcher could lead to safer and easier treatment for patients with coronary in-stent restenosis A new drug-eluting balloon can perform just as well as the standard treatment for patients with coronary in-stent restenosis (ISR) undergoing repeated percutaneous coronary intervention (PCI). These breakthrough findings of an international clinical trial led by a

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Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD

he New England Journal of Medicine (NEJM) today published a peer-reviewed original paper with the results of the landmark clinical trial demonstrating the efficacy of PRIMA brain computer interface (BCI) retinal implant. The paper showed PRIMA restored functional central vision; 80% of patients demonstrated meaningful improvement of visual acuity and were able to read letters, numbers, and words. The

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