Special delivery: McMaster physicists design ‘super-human’ red blood cells to deliver drugs to specific targets within the body

A team of physicists from McMaster University has developed a process to modify red blood cells so they can be used to distribute drugs throughout the body, which could specifically target infections or treat catastrophic diseases such as cancer or Alzheimer’s. The modified red blood cells are designed to circulate in the body for several

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Exploding cancer cells can cause serious side effects in CAR-T cell therapies

Blocking a protein makes cells shrink instead, causing fewer problems Techniques to genetically modify patient immune cells have revolutionized the fight against hard-to-treat cancers. But they can come with dangerous side effects. Now, researchers have found one reason why. A particularly messy form of cell death sparks severe inflammation in patients receiving CAR-T cell immunotherapy for blood

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ISSCR Issues Statement on Ethical Standards for Stem Cell-based Embryo Models

Original story from the International Society for Stem Cell Research The ISSCR is updating its Guidelines for Stem Cell Research and Clinical Translation to respond to recent scientific advances that include the use of pluripotent stem cell (PSC) to create models of early human embryo development. As the science continues to advance, it raises important

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Cancer study may accidentally help researchers create usable blood stem cells

Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies. Researchers have identified that increasing the expression of the normal form of the MLL gene can drive production of hematopoietic stem cells (HSCs). This not only provides a protocol

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The Lancet Digital Health: Real-time flu prediction may be possible using wearable heart rate and sleep tracking devices

First study to evaluate de-identified data from wearable devices on resting heart rate and sleep finds improved real-time prediction of influenza-like illness in 5 US states compared to current surveillance methods The research, published in The Lancet Digital Health journal, demonstrates the potential of data from wearable devices to improve surveillance of infectious disease. Resting heart rate

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New Microscopy Technique Shows Cells’ 3-D Ultrastructure in New Detail

The method melds the best of super-resolution fluorescence and electron microscopy to show how proteins relate to cells’ fine structure. Inside a cell, tentacled vesicles shuttle cargo for sorting. Neighboring neurons cling to one another through a web-like interface. DNA rearranges in the nucleus as stem cells differentiate into neurons. And a new microscopy technique

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Why stem cells could be the medical innovation of the century for World Economic Forum

Source World Economic Forum The current market for stem cell therapies is growing at 36% per year and will rapidly expand when a breakthrough treatment for non-communicable disease or a lifestyle factor occurs. Funding is flowing into the sector from venture capitalists and large companies. With greater resources and an increasingly experienced talent pool, scientists

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