Possible New Target for Sickle Cell Disease and Beta Thalassemia Treatment identified by Harvard Medical School Researchers

Researchers identify additional gene controlling production of fetal hemoglobin Harvard Medical School researchers at Boston Children’s Hospital and Dana-Farber Cancer Institute have identified a new pathway that regulates the production of fetal hemoglobin, a form of hemoglobin that normally gets replaced soon after birth by adult hemoglobin. Two FDA-approved gene therapies reactivate the production of

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New England Journal of Medicine: REACT reveals that silent atherosclerosis already affects 1 in 13 young adults aged 18 to 29 and progresses rapidly from the menopause

The research, presented in a Hot Line session at the European Society of Cardiology Congress in Munich and published simultaneously in The New England Journal of Medicine, proposes a paradigm shift towards prevention based on early detection through vascular imaging Atherosclerosis, the process underlying most cardiovascular diseases, begins long before the first symptoms appear. An international

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Retatrutide, new  Triple Hormone Receptor Agonist, Improves Weight Loss up to 30%, Knee Osteoarthritis Pain, Sleep Apnea Versus Placebo

Retatrutide treatment results in substantial weight loss among patients with obesity, as well as reduced pain in patients with knee osteoarthritis and reduced apnea-hypopnea events in patients with obstructive sleep apnea, according to the TRIUMPH-1 study.1 Earlier phase 2 trials including patients with obesity have indicated that once-weekly subcutaneous retatrutide resulted in substantial weight reductions

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American College of Cardiology Scientific Statement Says Overall Diet Quality Key to Maintaining Heart Health

A healthy, balanced dietary pattern, rather than one focused on individual nutrients or foods, is key to maintaining heart health, according to a new ACC Scientific Statement on Food and Health: Nutrition for Prevention and Management of Cardiovascular Disease. Read the full Statement in JACC. Key Takeaways The Statement reviews current evidence on nutrition and

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Research spotlight: How exercise protects joints in aging-related osteoarthritis

Hirotaka Iijima, PhD, PT, and Fabrisia Ambrosio, PhD, MPT, of the Discovery Center for Musculoskeletal Recovery within the Department of Physical Medicine and Rehabilitation at Mass General Brigham, are the lead and senior authors of a paper published in Nature Aging, “Exercise enhances aged chondrocyte health through microRNA29–enriched extracellular vesicles“. Osteoarthritis is one of the

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First severe human case of Oya virus reported in China. The new case involves a 54-year-old woman who worked at a goose farm in Qingyuan, in China’s Guangdong province.

China has confirmed the first documented case of a severe human infection caused by the Oya virus, a pathogen belonging to the Orthobunyavirus genus that had previously been identified primarily in mosquitoes and biting midges. This case provides insight into the virus’s effects and how it can be transmitted to humans. The case is published

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Mount Sinai Study Identifies Why Some Patients Develop Severe Intestinal Inflammation After CAR-T Therapy

Persistent CAR-T cells in the intestine and widespread immune disruption seen as possible drivers of a rare but serious complication Researchers at the Icahn School of Medicine at Mount Sinai have identified biological mechanisms that may contribute to CAR-T cell-associated enterocolitis, a serious inflammatory condition of the intestine that can occur after a type of

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