Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy

Chimeric antigen receptor (CAR) technology and its application to regulatory T cells (Tregs) has garnered interest among researchers in the field of cell and gene therapy. Merging the benefits of CAR technology with Tregs offers a novel and promising therapeutic option for durable reshaping of undesired immune responses following solid organ or hematopoietic stem cell

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NIH, receiving $48 million in support through Operation Warp Speed (OWS), expands clinical trials to test convalescent plasma against COVID-19

Rigorous studies to build on earlier efforts to test the experimental treatment Source NIH Two randomized, placebo-controlled clinical trials funded by the National Institutes of Health (NIH) are expanding enrollment to further evaluate convalescent plasma as a treatment for patients hospitalized with COVID-19. Preliminary observational studies indicate that convalescent plasma may improve outcomes among severely

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People with asymptomatic SARS-CoV-2 infection have an upper respiratory viral load as those with mild symptoms

They are relatively common so may act as important driver of viral spread, warn researchers People with ‘silent’ COVID-19 infection have as much coronavirus in their noses and throats as those with symptoms, reveals research published online in the journal Thorax. Given how many of these people there are—a fifth of those infected, the study findings show–they may

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Endothelial damage and a thin intercellular fibrin network promote coagulation disorders in acute promyelocytic leukaemia: a model for severe Covid-19 thrombo-hemorrhagic complications.

So far, early hemorrhagic death remains a major obstacle to complete remission in acute promyelocytic leukemia (APL). The number of leukemia cells in the blood is a better predictor of bleeding events than other hematological parameters. Vascular endothelial homeostasis is associated with spontaneous bleeding. In APL, how APL cells interact with vascular endothelial cells and

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Modulating endothelial adhesion and migration impacts stem cell therapies efficacy

Despite the first clinical studies reporting on a correlation betweenthe migration potential of transplanted stem cells and their therapeutic efficacy, it is unclear if effective stem cell therapies requirereliable and sufficient delivery of the cells to the desired anatomiclocations, as well as survival of the cellular graft. Moreover, the many complex processes involved in stem

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FDA Approves Study to Investigate the Use of Cell Therapy to Treat COVID-19 Related Multisystem Inflammatory Syndrome in Children (MIS-C)

First-of-its kind study to be supported by the Cura Foundation, The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now The Cura Foundation in collaboration with The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now, is supporting a clinical trial of human cord tissue mesenchymal stromal cells (hCT-MSC) to treat children with

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Frequency of Children vs Adults Carrying Severe Acute Respiratory Syndrome Coronavirus 2 Asymptomatically

The frequency of children carrying asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been suggested to be higher than among adults. It is also suggested that asymptomatic children enhance viral spread. A research letter by published in the journal JAMA Pediatrics in September 2020 explores the truth of this common belief. Earlier Research Earlier studies

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Efficacy of convalescent plasma against COVID19 requires early therapy with high titer plasma. RCTs need to be designed on this basis.

In a paper published on EClinicalMedicine, has been assessed outcome of patients with moderate and severe COVID-19 following treatment with convalescent plasma (CP) and the association with IgG levels in transfused CP. A prospective cohort study. Primary outcome was improvement at day 14 defined as alive, not on mechanical ventilation, and moderate, mild, or recovered

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