Archives June 2020

Alveolar macrophage dysfunction in the pathogenesis of two severe COVID-19 patients

The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatalorgan failure. The authors report the fundamental pathological investigation in the lungs and other organs of fatal cases after the autopsy and pathological investigations of specimens performed on

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Microwave-Generated Steam Decontamination of N95 Respirators Utilizing Universally Accessible Materials

Researchers of Harvard Medical School, Boston have devised a way to decontaminate N95 respirators using household supplies: glass containers, mesh from produce bags, a rubber band, and a microwave. The paper by Zulauf KE, Green AB, Nguyen Ba AN, Jagdish T, Reif D, Seeley R, Dale A, Kirby JE has been published on mBio 11:e00997-20.

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Covid-19:RECOVERY trial publishes preprint on dexamethasone use in ventilated patients

University of Oxford’s RECOVERY trial published its much anticipated preprint paper on the drug’s effect on Covid-19. The paper states that the drug cuts deaths in ventilated patients by one third and deaths in other admitted patients receiving oxygen by only one fifth. The headline findings of the trial were reported by the investigators on 16

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Mayo Clinic finds convalescent plasma safe for diverse patients with COVID-19

Mayo Clinic researchers and collaborators have found investigational convalescent plasma to be safe following transfusion in a diverse group of 20,000 patients. The findings — from the U.S. Food and Drug Administration’s Expanded Access Program for COVID-19 — are reported in Mayo Clinic Proceedings. The safety report assessed the seven days following transfusion for hospitalized patients between April

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Covid-19: are interferons helping or harming ?

The host immune system produces a variety of regulatory molecules, including interferons (IFNs), during a response to viral infection. Although previously considered beneficial, these proteins may actually cause life-threatening inflammation, according to an article published in Science on June 11. IFNs are a group of signaling proteins that are made and released by host cells in response

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Individualized Treatment for COVID-19 Patients Should Be Based on Three Disease Phases

Review encourages medical personnel to develop personalized treatment based on patient’s pathophysiology A new review details three distinct phases of COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, and urges medical professionals to consider an individualized treatment approach based on the disease phases and each patient’s symptoms. The reviewis published ahead of print in Physiological Reviews.

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In JAMA Patient Page an information on Convalescent Plasma and Covid-19

Donated convalescent plasma may be beneficial to patients with severecoronavirus disease 2019 (COVID-19) to boost their ability to fight the virus. What Is Convalescent Plasma?Most people who recover from COVID-19 develop antibodies (proteins that the immune system produces in response to infection) to severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). Antibodies are found in plasma,

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