Archives: 2023-12-11

First-in-human clinical trial of CAR T cell therapy with new binding mechanism shows promising early responses

Improving CART19 function by targeting a membrane-proximal CD19 epitope with fast on- and off-rates. Early results for the Penn Medicine-developed AT101 presented at ASH Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response

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FDA Approves First CRISPR-based Gene Therapies to Treat Patients with Sickle Cell Disease

The U.S. Food and Drug Administration approved two milestone treatments, Casgevy and Lyfgenia, representing the first cell-based gene therapies for the treatment of sickle cell disease (SCD) in patients 12 years and older. Additionally, one of these therapies, Casgevy, is the first FDA-approved treatment to utilize a type of novel genome editing technology, signaling an

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Personalized cancer medicine: humans make better treatment decisions than AI

Charité study highlights limits of large language models in precision medicine Treating cancer is becoming increasingly complex, but also offers more and more possibilities. After all, the better a tumor’s biology and genetic features are understood, the more treatment approaches there are. To be able to offer patients personalized therapies tailored to their disease, laborious

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Vitamin B12: a key player in cellular reprogramming and tissue regeneration

Researchers at IRB Barcelona reveal that vitamin B12 significantly boosts the efficiency of cellular reprogramming, thus holding promise for regenerative medicine. Vitamin B12 supplementation shows potential in speeding up tissue repair in a model of ulcerative colitis—an observation that points to potential new treatments for inflammatory diseases. The discovery has been published in the journal Nature

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Cordio HearO® system an AI phone app detects worsening heart failure based on changes in patients’ voices

A smartphone app using artificial intelligence technology to detect changes in the voice of a person with heart failure predicted more than 75% of hospitalizations about three weeks before they happened, according to late-breaking science presented Nov. 13 at the American Heart Association’s Scientific Sessions 2023. The meeting, held Nov. 11–13, in Philadelphia, is a premier global exchange

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Patients with high levels of triglycerides and diglycerides in blood samples are more likely to develop glaucoma

Glaucoma remains one of the most common causes of vision loss and blindness in the U.S. and much of the world, disproportionately affecting older people, African Americans, and Hispanics and Latinos. Early signs of glaucoma can vary, from eye pressure to changes in the appearance of the optic nerve, and the disease can progress for

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Study Shows Stem Cell Transplant Significantly Improves Outcomes in Refractory Juvenile Systemic Sclerosis

New research at ACR Convergence 2023, the American College of Rheumatology’s (ACR) annual meeting, shows that patients with refractory juvenile systemic sclerosis improved significantly on nearly all measures for two years following autologous stem cell transplant (Abstract #L06). Juvenile-onset systemic sclerosis (jSSc), also called scleroderma, is a disfiguring autoimmune disorder marked by hardening of the skin

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