Innovative gene therapy developed to treat a rare and devastating genetic heart disease in young men

A CNIC team has designed a gene therapy-based treatment that could transform the approach to arrhythmogenic cardiomyopathy type 5 (ARVC5), a rare and fatal genetic disease that particularly affects young men. A team from the  National Center for Cardiovascular Research (CNIC) has developed an innovative gene therapy that could transform the treatment of arrhythmogenic cardiomyopathy type 5 (ARVC5),

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Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

A new study published in Nature Cardiovascular Research found that while carotid artery narrowing can lead to stroke in both men and women, the symptoms and plaque characteristics often differ between the sexes. Even though the main types of cells in the plaques are similar, important differences exist in the smaller structures within those cells. According to the World

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The Mediterranean diet and physical activity maintain bone health in older adults

Following a low-calorie Mediterranean diet and regular physical activity mitigates the decline in bone health in older adults with metabolic syndrome , especially women. These are the main conclusions of a study led by a research team from the Rovira i Virgili University (URV) published in the scientific journal JAMA Network Open. The study included 924 men and women

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Regular Salt Substitution with Added-potassium salt lowers Recurrent Stroke and Death risk

Large clinical trial shows that replacing regular salt with a sodium-potassium blend offers a simple, low-cost intervention for stroke patients A recent randomized clinical trial claims that salt substitutes are safe and effective over regular salt in terms of reducing the risk of recurrent stroke and death in patients with a history of stroke. The detailed

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Stephen Hauser and Andrea Ascherio Win Breakthrough Prize in Life Sciences for Role in Redefining MS

Stephen hauser and Andrea Ascherio have played a pivotal part in identifying the cause of multiple sclerosis, leading to a new generation of game-changing therapies. Neuro-immunologist Stephen Hauser, MD, whose maverick thinking transformed the treatment landscape for patients with multiple sclerosis (MS), has received the 2025 Breakthrough Prize in Life Sciences. Hauser, a UCSF professor of

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Major advances in the treatment of type 1 diabetes

Recent decades have seen a lot of progress in diabetes treatment. In a new study, Per-Ola Carlsson, Professor of Medical Cell Biology, has obtained promising results. “This is the first time anyone has succeeded in transplanting insulin-producing cells into another individual without immunosuppressive drugs,” he says. The treatment available for type 1 diabetes since the

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Mass General Brigham Researchers Reveal 17 Modifiable Risk Factors Shared by Stroke, Dementia, and Late-Life Depression

Age-related brain diseases such as stroke, dementia, and late-life depression are a debilitating part of growing older, but people can lower their risk of these diseases through behavioral and lifestyle changes. In a new extensive systematic review, Mass General Brigham researchers identified 17 modifiable risk factors that are shared by stroke, dementia, and late-life depression. Modifying any

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Pedometers suffice for measuring health-promoting physical activity

A basic pedometer can prove suffice for measuring health-promoting physical activity, according to a study comparing pedometers with more complex devices. Simply counting steps captured a remarkable amount of information about the participants’ aerobic fitness and cardiovascular health. The general recommendation for physical activity is to be active at least at a moderate intensity for

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