Thromboprophylaxis with enoxaparin is associated with a lower death rate in patients hospitalized with SARS-CoV-2 infection. A cohort study published on EClinicalMedicine

Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection is associated with hypercoagulability caused by direct invasion of endothelial cells and\or proinflammatory cytokine release. Thromboprophylaxis with enoxaparin is recommended by current guidelines, but evidence is still weak. The aim of this study was to assess the impact of thromboprophylaxis with enoxaparin on hospital mortality in patients

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The role for the metagenome and the influence of microbiota on immune processes in the pathogenesis of COVID-19 infection.

A new paper published on EBioMedicine analyzes metagenome contribution to Covid-19 response variability. A key question concerning COVID-19 is why most infected persons do not develop severe disease, while others become critically ill. This dichotomy is related to age, gender, immunosuppression and comorbidities, but many persons who are young succumb to the virus. A significant

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Neutrophil proteolytic enzymes storm triggers vascular disease and thrombosis in SARS-CoV-2 infected Rhesus Macaques

The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, was demonstrated endothelial disruption and vascular thrombosis in histopathologic sections of lungs from both humans and

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SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host interferons

SARS-CoV-2 is a recently identified coronavirus that causes the respiratory disease known as COVID-19. Despite the urgent need, it’s not fully understood the molecular basis of SARS-CoV-2 pathogenesis. In this paper, are comprehensively defined the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing

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A large-scale Multi-omic Analysis shows neutrophil degranulation, vessel damage, platelet activation and degranulation, blood coagulation and complement activation are responsible for COVID-19 Severity

RNA-Seq and high-resolution mass spectrometry on 128 blood samples from COVID-19 positive and negative patients with diverse disease severities and outcomes were performed and published on Cell Systems Quantified transcripts, proteins, metabolites, and lipids were associated with clinical outcomes in a curated relational database, uniquely enabling systems analysis and cross-ome correlations to molecules and patient

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COVID-19 transmission rebounds quickly after physical distancing rules are relaxed

Across the U.S., the relaxation of statewide physical distancing measures that are designed to control the COVID-19 pandemic frequently resulted in an immediate reversal of public health gains against SARS-CoV-2, the virus that causes the disease, researchers from Massachusetts General Hospital (MGH) and colleagues reported. Looking at data from all 50 states and the District

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Experts reaction to Barrington Declaration,open letter arguing against lockdown policies and for ‘Focused Protection’.

An open letter has been published, arguing against lockdown policies and for ‘Focused Protection’. Here are responses of some actual top scientists to the herd immunity declaration from other scientists (many of whom have never published a peer-reviewed paper on Covid-19). Dr Julian Tang, Honorary Associate Professor in Respiratory Sciences, University of Leicester, said: “Having

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Sarilumab use in severe SARS-CoV-2 pneumonia. IL-6 blockade inhibits neutrophil recruitment and innate immune response harm.

Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress. In this paper, published on EClinicalMedicine are described the outcomes of off-label intravenous use of Sarilumab in severe SARS-CoV-2-related pneumonia. 53 patients with SARS-CoV-2 severe pneumonia received intravenous Sarilumab; pulmonary function improvement or Intensive Care Unit (ICU)

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Prevalence and prognostic value of Delirium as the initial presentation of COVID-19 in the elderly with dementia: An Italian retrospective study

Delirium may be one of the presenting symptoms of COVID-19, complicating diagnosis and care of elderly patients with dementia. The autors aim to identify the prevalence and prognostic significance of delirium as the sole onset manifestation of COVID-19 in a retrospective single-centre study based on review of medical charts, conducted during the outbreak peak (March

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Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

The contribution of CD4 + T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. In this paper it’s presented single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4 + T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, were found increased proportions of cytotoxic follicular helper (T FH

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