Antiviral-Resistant Variants of SARS-CoV-2 Can Emerge in Immunocompromised People

Researchers isolated SARS-CoV-2 strains, which are drug resistant with mutations to the nsp12 protein that is the target of remdesivir and another variant with mutations to the nsp5 protein, the target of Paxlovid. These mutations help the virus persist in people with compromised immunity despite common antiviral treatments. Individuals with compromised immunity and persistent COVID-19

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Immune response study explains why some people don’t get COVID-19

Using single-cell sequencing technology, researchers provide the most comprehensive timeline to date of how the body responds to SARS-CoV-2 exposure. Scientists have discovered novel immune responses that help explain how some individuals avoid getting COVID-19. Using single-cell sequencing, researchers from the Wellcome Sanger Institute, University College London (UCL), Imperial College London, the Netherlands Cancer Institute

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Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients

Even though COVID-19 manifests as a mild and short-lived disease in most people, some suffer extremely severe symptoms; in the worst cases, these patients die due to complications such as respiratory failure or thromboembolism. It is well-known that factors such as age and underlying medical conditions like diabetes or immunodeficiencies increase vulnerability to severe COVID-19.

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FDA panel recommends updating the Covid vaccines for the fall to target JN.1 strain

FDA advisers say new shots can target more recent SARS-CoV-2 variants SARS-CoV-2 keeps evolving, and it’s time for COVID-19 vaccines to again follow suit, advisers to the U.S. Food and Drug Administration (FDA) agreed today. The panel voted unanimously in favor of updating the shots to more closely match virus strains now circulating. Although FDA

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The Route Into the Cell Influences the Outcome of Sars-Cov-2 Infection

A surface protein helps viruses to enter cells. This has far-reaching consequences for the infection. How exactly do Sars-Cov-2 particles enter host cells? An international team led by Dr Richard Brown from Dr Daniel Todt’s Computational Virology group at the Department of Molecular and Medical Virology at Ruhr University Bochum, Germany, together with researchers from

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