Researchers isolated SARS-CoV-2 strains, which are drug resistant with mutations to the nsp12 protein that is the target of remdesivir and another variant with mutations to the nsp5 protein, the target of Paxlovid. These mutations help the virus persist in people with compromised immunity despite common antiviral treatments. Individuals with compromised immunity and persistent COVID-19
Fibrin (red) and toxic microglia (green) in the brain of a mouse infected with COVID-19. Image courtesy of Jae Kyu Ryu and Katerina Akassoglou. In a study that reshapes what we know about COVID-19 and its most perplexing symptoms, scientists have discovered that the blood coagulation protein fibrin causes the unusual clotting and inflammation that
Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variants. A Phase 1 trial testing the safety of an experimental nasal vaccine that may provide enhanced breadth of protection against emerging variants of SARS-CoV-2, the virus that causes COVID-19, is now enrolling healthy adults at three sites in the United States. The National
Using single-cell sequencing technology, researchers provide the most comprehensive timeline to date of how the body responds to SARS-CoV-2 exposure. Scientists have discovered novel immune responses that help explain how some individuals avoid getting COVID-19. Using single-cell sequencing, researchers from the Wellcome Sanger Institute, University College London (UCL), Imperial College London, the Netherlands Cancer Institute
Even though COVID-19 manifests as a mild and short-lived disease in most people, some suffer extremely severe symptoms; in the worst cases, these patients die due to complications such as respiratory failure or thromboembolism. It is well-known that factors such as age and underlying medical conditions like diabetes or immunodeficiencies increase vulnerability to severe COVID-19.
Similar to smokers, cannabis users nearly twice as likely to need hospitalization, intensive care when infected with the virus As the deadly disease that came to be known as COVID-19 started spreading in late 2019, scientists rushed to answer a critical question: Who is most at risk? They quickly recognized that a handful of characteristics
FDA advisers say new shots can target more recent SARS-CoV-2 variants SARS-CoV-2 keeps evolving, and it’s time for COVID-19 vaccines to again follow suit, advisers to the U.S. Food and Drug Administration (FDA) agreed today. The panel voted unanimously in favor of updating the shots to more closely match virus strains now circulating. Although FDA
Study also shows that patients hospitalized within 30 days after infection face 29% higher death risk in 3rd year compared with those not infected New findings on long COVID by Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system reveal that COVID-19 patients who were hospitalized within
A surface protein helps viruses to enter cells. This has far-reaching consequences for the infection. How exactly do Sars-Cov-2 particles enter host cells? An international team led by Dr Richard Brown from Dr Daniel Todt’s Computational Virology group at the Department of Molecular and Medical Virology at Ruhr University Bochum, Germany, together with researchers from
A rare condition surged among previously unaffected groups of people during the COVID-19 pandemic and led to the deaths of nine patients, researchers say. The condition is a type of autoimmune response linked to the body immune system mistakenly attacking itself. Intriguingly, the system being attacked normally works as a sentinel or guard, whose
