Archives: 2021-11-17

First Data show Pfizer PF-07321332 Protease Inhibitor pill is effective in Preventing Severe COVID-19

Over the course of this pandemic, significant progress has been made in treating COVID-19 and helping to save lives. That progress includes the development of life-preserving monoclonal antibody infusions and repurposing existing drugs, to which NIH’s Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership has made a major contribution. But for many months we’ve had hopes that a

Read More


Incidence and risk factors associated with bleeding and thrombosis following chimeric antigen receptor T-cell therapy

Chimeric antigen receptor T-cell (CAR T) therapy has revolutionized the field of malignant hematology. CD19-targeted CAR T-cell therapy has resulted in effective, often durable, responses for chemotherapy-refractory B-cell lymphoma and B-acute lymphoblastic leukemia (B-ALL) in prospective clinical trials. CAR T cells against B-cell maturation antigen have also shown overall response rates in the range of

Read More


Monash University study uncovers a new understanding of how mesenchymal stromal cells benefit patients in cell therapy

The therapeutic benefit to patients receiving mesenchymal stromal cell (MSC) therapy is not because the injected cells remain viable, but because of cell death, researchers at the Monash Biomedicine Discovery Institute (BDI) have found. In recent years, significant efforts have been made to develop stem cell-based therapies for difficult-to-treat diseases. MSC therapy is regenerative cell-based

Read More


Low-molecular-weight heparin use in Covid-19 is associated with curtailed viral persistence: a retrospective multicentre observational study

Clotting problems and resulting complications are common in COVID-19 patients. Researchers at the Medical University of Vienna have now shown that a member of the anticoagulant group of drugs not only has a beneficial effect on survival of COVID-19 patients, but also influences the duration of active infection with the SARS-CoV-2 coronavirus. The results were

Read More


New research by Boston Children’s Hospital on ricolinostat repurposing to curb neutrophil extracellular traps (NETs) and to fight severe inflammation in Covid-19

As we’ve seen during the COVID-19 pandemic, serious infections sometimes trigger an excessive inflammatory reaction that does as much harm — or more — than the infection itself. New research at Boston Children’s Hospital and Brigham and Women’s Hospital suggests a potential way to block this hyperinflammation response by repurposing or modifying an existing drug.

Read More


Direct Comparison of Antibody Responses to Pfizer, Astrazeneca, Sputnik V and Sinopharm SARS-CoV-2 Vaccines in Mongolia: study published in Cell Host & Microbe by Stanford University

Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. In thi paper the authors collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19 vaccines: Pfizer/BioNTech, AstraZeneca, Sputnik V and Sinopharm. Functional antibody testing with a

Read More


Study reveals tactics used by US stem cell clinics to market their treatments

Stem cell clinics continue to thrive in the US and worldwide, building their business on misleading advertising and offering unapproved and unproven stem-cell-based interventions (SCBI). A research recently published in Stem Cell Reports by Emma Frow, David Brafman, and colleagues from Arizona State University, asked what kinds of claims and evidence these clinics use to market their

Read More


Covid-19 vaccines protection against hospitalization and ICU effectiveness dropping over time: results in different studies

As millions of eligible people consider getting a booster shot, many are wondering what the data tells us about the effectiveness of the vaccines, and how much their protection might be waning. The good news is that a growing body of research shows that the vaccines authorized remain highly protective against severe disease and hospitalization

Read More


SARS-CoV-2 uses sugars to invade human cells, new study by University of Alberta shows

Understanding the process could help scientists look out for new, more infectious variants. Sugars found on the surface of human cells influence COVID-19 infection, according to a University of Alberta-led study that is one of the first to observe this relationship and suggests that cells in the brain might be particularly susceptible. “The idea here is that

Read More


Novel mesenchymal stem cell therapy approach proves effective in treating COVID-19

An international team of researchers has advanced a new therapeutic approach using stem cells to treat COVID-19. Despite many advances in treating the COVID-19 virus there remains no specific cure for patients with infection. This is especially the case with hospitalised patients who end up in the ICU requiring mechanical ventilation support. Key members of

Read More