Study reveals how the same molecules that promote healthy aging can fuel cancer growth through distinct molecular pathways Polyamines, a group of naturally occurring molecules found in all living organisms, are essential for fundamental cellular processes, such as growth and differentiation. In recent years, these compounds (particularly spermidine) have gained attention as promising ‘geroprotectors’ that
On Dec 19, 2025, the US Food and Drug Administration (FDA) announced a major milestone by qualifying total hip bone mineral density (BMD), assessed by dual-energy X-ray absorptiometry, as a surrogate endpoint for fractures in phase 3 trials of investigational drugs in postmenopausal women with osteoporosis. The qualification was based on data generated by the
Research conducted on rats reinforces the idea that proton pump inhibitors, which are widely used to treat stomach problems, can affect mineral absorption and compromise bone health. A study conducted in Brazil by researchers at the Federal University of São Paulo (UNIFESP) and the ABC Medical School (FMABC) warns that the prolonged use of proton
Almost half of patients admitted to hospital for acute heart failure in Europe are readmitted within a year, according to a new study led by researchers at Karolinska Institutet and published in the European Heart Journal. In addition, the risk of death remains high, especially for those with more severe heart failure. Heart failure is
Sinai Health researchers have shown a blood test can predict Crohn’s disease years before symptoms appear, opening the doors to early diagnosis and potentially prevention. The test measures a person’s immune response to flagellin, a protein found on gut bacteria. This response is elevated in individuals long before they develop Crohn’s Disease, a team led
Researchers show how exercise protects the brain against stroke by inducing migration of tiny powerhouses through the bloodstream. While thrombolytic therapy remains one of the most effective strategies for stroke recovery, it is effective only for a short span of time. Now, researchers from Japan have demonstrated how numerous mitochondria, the powerhouses of the cell,
Autoimmune diseases such as multiple sclerosis arise when the immune system turns against the body itself. Yet for most of them, it remains unclear why this process begins. Researchers have now identified how the Epstein-Barr virus can, under specific conditions, initiate early multiple sclerosis-like damage in the brain. This offers a new perspective on how
Zycubo (copper histidinate) is a new under-the-skin injection that the FDA has approved for treating children with a rare genetic condition that affects copper metabolism, known as Menkes disease. Menkes disease is caused by mutations in the copper transporter gene (ATP7A), making it hard for the body to absorb and use copper, an important mineral
A major international study led by Mayo Clinic researchers and funded by the National Institutes of Health found that for people with severe carotid artery narrowing who haven’t experienced recent stroke symptoms, a minimally invasive procedure called carotid artery stenting, combined with intensive medical therapy, significantly lowered stroke risk compared with medical therapy alone. Traditional surgery (carotid endarterectomy) did not show the
For high-risk patients, the method could offer a safer alternative to open-heart surgery. In a world first, a team of researchers at the National Institutes of Health (NIH) and Emory School of Medicine, Atlanta, has successfully performed a coronary artery bypass — a normally open-heart surgery — without cutting the chest wall. The team employed a novel
