Sinai Health researchers have shown a blood test can predict Crohn’s disease years before symptoms appear, opening the doors to early diagnosis and potentially prevention. The test measures a person’s immune response to flagellin, a protein found on gut bacteria. This response is elevated in individuals long before they develop Crohn’s Disease, a team led
“Charting the Translational Pathway: ISSCR Best Practices for the Development of PSC-Derived Therapies,” offers insights into the comprehensive, globally informed guide to navigating the complex journey from laboratory discovery to approved therapy. The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of “Charting the Translational Pathway: ISSCR Best Practices for the
Researchers show how exercise protects the brain against stroke by inducing migration of tiny powerhouses through the bloodstream. While thrombolytic therapy remains one of the most effective strategies for stroke recovery, it is effective only for a short span of time. Now, researchers from Japan have demonstrated how numerous mitochondria, the powerhouses of the cell,
Autoimmune diseases such as multiple sclerosis arise when the immune system turns against the body itself. Yet for most of them, it remains unclear why this process begins. Researchers have now identified how the Epstein-Barr virus can, under specific conditions, initiate early multiple sclerosis-like damage in the brain. This offers a new perspective on how
In a Phase 1 clinical study, researchers led by EPFL and their partners report that a new liver- and gut-targeted oral drug can safely lower triglycerides and other blood lipids. When we eat, our bodies convert extra calories, especially from carbs, sugar, fats, and alcohol, into molecules called “triglycerides”. Triglycerides are a form of fat
Chronic low back pain significantly affects quality of life for millions of people worldwide. Back pain makes it difficult to perform everyday tasks and is among the leading reasons why patients see their doctor. Some back pain comes from the bones themselves, known as the vertebrae, not just the discs in the spine. Damage and
Zycubo (copper histidinate) is a new under-the-skin injection that the FDA has approved for treating children with a rare genetic condition that affects copper metabolism, known as Menkes disease. Menkes disease is caused by mutations in the copper transporter gene (ATP7A), making it hard for the body to absorb and use copper, an important mineral
Exercise restores a key cellular balance in ageing muscles, helping them stay stronger and more resilient. Scientists at Duke-NUS Medical School have uncovered how exercise helps ageing muscles regain their ability to repair themselves, shedding light on why physical activity remains one of the most effective ways to preserve strength and mobility later in life.
A new study led by Baylor College of Medicine and presented at the American College of Cardiology’s Annual Scientific Session together with World Congress of Cardiology found that an oral PCSK9 inhibitor called MK-0616 reduced LDL, or “bad,” cholesterol by more than 60%. MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, substantially
A major international study led by Mayo Clinic researchers and funded by the National Institutes of Health found that for people with severe carotid artery narrowing who haven’t experienced recent stroke symptoms, a minimally invasive procedure called carotid artery stenting, combined with intensive medical therapy, significantly lowered stroke risk compared with medical therapy alone. Traditional surgery (carotid endarterectomy) did not show the
