Mass General Brigham researchers identify conserved gene expression signatures linked to biological aging and risk of disease and mortality, offering a new framework for quantifying aging and evaluating interventions that modulate healthspan and lifespan A team led by investigators at Mass General Brigham has discovered that different tissues in humans and other mammals share common gene expression
The interim Phase I trial data was only from 35 people, but results look good so far. An experimental gene-editing therapy that aims to lower bad cholesterol for the long-term after a single infusion is off to a positive start in an early clinical trial. Researchers running a Phase I safety trial for the drug,
Sitting for More Than 10 Hours a Day Doubles Risk. Need to Increase Walking and Low-Intensity Activities A study has found that the longer a woman spends sitting during pregnancy, the greater the risk of health issues related to pregnancy and childbirth, such as gestational hypertension or premature birth, while conversely, increasing light physical activity
Researchers are testing CAR T cell therapy as a way to reset the immune system in lupus, Graves’ disease and other conditions where the body’s defenses go rogue At age 49, Jan Janisch-Hanzlik’s multiple sclerosis was destroying her freedom to live the life she wanted. She gave up her active nursing job for a desk
Summary The oral medication avatrombopag proved highly effective against chemotherapy-induced thrombocytopenia (CIT) in a phase 2 clinical trial of patients with gastrointestinal cancers. CIT is a major burden in cancer treatment and can cause treatment delays that significantly impact patients’ outcomes. The senior author of the study is Sylvester’s chief of the classical hematology service,
NIH-funded study incorporates new measures to better predict outcomes in chronic heart condition. Findings from a study supported in part by the National Institutes of Health (NIH) have identified a new model for predicting outcomes for hypertrophic cardiomyopathy (HCM), a heart condition with a prevalence of 1 in 500 people and a frequent cause of
UT South Western-led Kenya study suggests relatively inexpensive technology could reduce cardiac health disparities in developing countries Interpreting relatively inexpensive electrocardiograms (ECGs) with an artificial intelligence (AI) algorithm accurately screened patients for a key precursor of heart failure in Kenya, a study led by UT Southwestern Medical Center researchers shows. The results, published in JAMA Cardiology, suggest
Developed in partnership with NYU Grossman School of Medicine investigators, the tool predicted risk among more than 6.4 million people across the world. Atool developed by the American Heart Association (AHA), already proven to accurately predict heart disease risk for Americans, can also be applied to the global population, a new study led by NYU
Abdominal contractions are tightly linked to gentle brain movements that help circulate cerebrospinal fluid, researchers find in mouse study The brain is more mechanically connected to the body than previously appreciated, scientists reported today (April 27) in Nature Neuroscience. Through a study using mice and simulations, the team found a potential biological mechanism underlying why exercise is
Stem-cell memory T (TSCM) cells are a rare subset of immune cells with the ability to self-renew, persist long term, and mount potent anti-tumor responses. These properties make them an attractive candidate for next-generation CAR T-cell therapies. However, their clinical potential has not previously been demonstrated in humans. An international team of researchers co-led by
