The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid 2 phosphorylation and inhibits viral infection in vitro

A cross-institutional effort between researchers at Weill Cornell Medicine and Duke University has yielded exciting progress in the search for new therapeutics against Covid-19. Where much of our current anti-SARS-CoV-2 arsenal is built around the virus’ spike (S) protein, many other proteins contribute to the viral life cycle as well. This includes the nucleocapsid (N) protein, which

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Researchers discover dysregulation of the immune system mediated by ATP as a new mechanism associated with severe COVID-19.

Researchers at the University of São Paulo (USP) in Brazil have found that severe COVID-19 is associated with an imbalance in an important immune system signaling pathway. The discovery helps explain at the molecular level why some people infected by SARS-CoV-2 develop a potentially fatal systemic inflammation. It also paves the way to the development

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New Omicron subvariant BQ.1.1 resistant to all therapeutic antibodies

Are the currently approved antibody therapies used to treat individuals at increased risk for severe COVID-19 disease also effective against currently circulating viral variants? A recent study by researchers at the German Primate Center (DPZ) – Leibniz Institute for Primate Research and Friedrich-Alexander University Erlangen-Nürnberg shows that the Omicron sub-lineage BQ.1.1, currently on the rise

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Gene-delivering viruses reach the brain in a step toward gene therapy for neurological diseases

Researchers have engineered a family of adeno-associated viral vectors that cross the blood-brain barrier in primate models. Gene therapies can treat, even potentially cure, certain genetic diseases, but it is challenging to deliver the treatments to the parts of the body where they are needed. Researchers have engineered viruses called adeno-associated viruses (AAVs) to deliver

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CRISPR Technology applied to CAR T cells for Cancer Therapy

Researchers find that combining novel gene-editing CRISPR technology with CAR T therapy could simplify and improve CAR T therapy in one fell swoop. Traditional CAR T Therapy A remarkable feat in cancer care, today people with difficult-to-treat blood cancers can receive CAR T therapy, a personalized “drug” made from their own immune cells. Chimeric Antigen Receptor T cell (CAR T)

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COVID-19 Virus Increases Risk for Other Infections by Disrupting Normal Mix of Gut Bacteria

Infection with the pandemic virus, SARS-CoV-2, can reduce the number of bacterial species in a patient’s gut, with the lesser diversity creating space for dangerous microbes to thrive, a new study finds. The study builds on the realization that widespread use of antibiotics to fight infections with disease-causing bacteria in recent decades, by killing off

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CAR T-Cell Therapies in Relapsed/Refractory Multiple Myeloma

The increasing integration of CAR T-cell therapies into the treatment paradigm for adult patients with relapsed or refractory multiple myeloma addresses several unmet needs and improves outcomes for this historically limited patient population. The increasing integration of CAR T-cell therapies into the treatment paradigm for adult patients with relapsed or refractory multiple myeloma addresses several

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Association of National Football League Fan Attendance With County-Level COVID-19 Incidence in the 2020-2021 Season

A study of National Football League (NFL) home games attended by 1.3 million fans suggests that those with high attendance were tied to subsequent county-level COVID-19 surges during the 2020-2021 season. A team led by a University of Southern Mississippi researcher analyzed data from all 32 NFL teams during the 2020-2021 season, when some games were open

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Comparative Risk of Thrombosis With Thrombocytopenia Syndrome or Thromboembolic Events Associated With Different COVID-19 Vaccines published in BMJ

OBJECTIVE To quantify the comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with use of adenovirus based covid-19 vaccines versus mRNA based covid-19 vaccines. DESIGN International network cohort study. SETTING Routinely collected health data from contributing datasets in France, Germany, the Netherlands, Spain, the UK, and the US. PARTICIPANTS Adults (age ≥18

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Cleveland Researchers Discover New Oral Drug for Lowering Cholesterol

Study led by University Hospitals and Case Western Reserve University team details a small-molecule drug that lowers cholesterol by 70% in animal models –After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are

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Research brief by Minnesota University: Association between diabetes medication and less severe cases of COVID-19

Published in PLOS ONE, a study led by the University of Minnesota Medical School studied adults with type 2 diabetes who were taking metformin, a commonly prescribed diabetes medication. Researchers found an association with less severe cases of COVID-19 for those prescribed metformin. These findings were part of an observational study that analyzed electronic medical

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Real-world evidence study of regenerative medicine and shoulder surgery

Applying regenerative medicine to a common shoulder surgery could have an impact on the need for follow-up revision surgery in some patients, according to a Mayo Clinic study of real-world evidence. Mayo Clinic researchers analyzed the largest set of data available to determine if adding bone marrow aspirate concentrate to repaired tissue after standard rotator cuff surgery would improve

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Anti-Vax Doctor Simone Gold Sued by America’s Frontline Doctors, the Group She Founded: misused the organization’s funds to buy a $3.6 million Florida mansion, purchase a Mercedes-Benz and other luxury vehicles, and take trips on private planes.

Source: Medscape America’s Frontline Doctors is suing one of its founders in a battle for control over the controversial group, which gained national notoriety for spreading misinformation about COVID-19 treatments and vaccines during the pandemic. The organization and its current board chairman have sued Simone Gold, MD, alleging that she misused the nonprofit organization’s funds

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Glucose metabolites, rather than glucose itself, have been discovered to be key to the progression of type 2 diabetes.

Oxford Research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes.  In diabetes, the pancreatic beta-cells do not release enough of the hormone insulin, which lowers blood glucose levels. This is because a glucose metabolite damages pancreatic beta-cell function. An estimated 415 million people globally are living with diabetes. With nearly 5

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Long-term efficacy of nusinersen and its evaluation in adolescent and adult patients with spinal muscular atrophy types 1 and 2

Therapy up to 4.5 years led to gains in motor function: analysis published in Brain & Development Up to 4.5 years of Spinraza (nusinersen) treatment led to meaningful improvements in motor function in adolescents and adults with spinal muscular atrophy (SMA), according to a medical records analysis. “[Spinraza] was effective in long-term follow-up,” researchers wrote. Noting a dearth of

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Technion researchers have developed a technology to measure the long-term effect of antibiotic “combination therapies”

Researchers at the Technion have developed a technology to measure the long-term effect of antibiotic combinations (cocktails). These combinations are of concern to the scientific and medical community due to the fact that the use of single antibiotics often leads to the rapid development of bacterial resistance to antibiotics. The research published in Nature was led by Technion

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How Covid-19 leads to neuronal damage

Although the Sars-CoV-2 coronavirus does not affect nerve cells, Covid-19 disease can cause damage to the nervous system. Researchers from the University of Basel and the University Hospital Basel have elucidated the mechanisms behind “Neuro-Covid” and identified starting points for preventing it. Quite a few have lost their sense of smell and taste with the coronavirus

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection: increased risk of fatal complications.

Many people worldwide are experiencing repeat SARS-CoV-2 infections, but the health risks associated with these reinfections have remained unclear. Now,  a team of researchers led by Washington University in St. Louis has found that repeated COVID-19 infections increase the risk of organ failure and death. “During the past few months, there’s been an air of invincibility among people who

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WHO releases first data on global vaccine market since COVID-19

WHO’s Global Vaccine Market Report 2022, published today, shows that inequitable distribution is not unique to COVID-19 vaccines, with poorer countries consistently struggling to access vaccines that are in-demand by wealthier countries. WHO’s Global Vaccine Market Report 2022, published today, shows that inequitable distribution is not unique to COVID-19 vaccines, with poorer countries consistently struggling to access

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Study lead by UMass Chan clinical scientists provides evidence of protective link between oral microbiome and COVID

Oral microbiome composition indicative of need for respiratory support among COVID-19 patients Using high-throughput genome sequencing and machine learning, scientists at UMass Chan Medical School have shown a strong correlation between the oral microbiome in patients with COVID-19 at the time of hospital admission and the need for later respiratory support. Published in Frontiers in Microbiology,

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New Exa-cel gene therapy for Sickle Cell Disease and Beta Thalassemia global regulatory submission in 2022

A potential 1-time gene editing treatment for severe sickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT) is entering approval review by the US Food and Drug Administration (FDA), the European Medicines Agency, and the UK Medicines and Healthcare products Regulatory Agency, according to a company statement. Both diseases involve variants in the gene encoding β globin. The variants

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US FDA grants Rare Pediatric Disease Designation to gene therapy OTOF-GT for the treatment of otoferlin gene-mediated hearing loss

OTOF-GT targets the restoration of hearing in people living with otoferlin deficiency Sensorion, a pioneering clinical-stage biotechnology company which specializes in the development of novel therapies to restore, treat and prevent hearing loss disorders, announces that the US Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation to the Company’s lead therapy gene

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Which COVID Vaccine You Get Can Impact Myocarditis Risk: study published in the Journal of the American College of Cardiology

Study shows higher rates of heart inflammation with Moderna vs. Pfizer, but overall risk still very low Incidence of myocarditis, pericarditis or myopericarditis is two- to threefold higher after a second dose of the Moderna Spikevax COVID-19 vaccine when compared to the Pfizer BioNTech COVID-19 vaccine; however, overall cases of heart inflammation with either vaccine

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COVID-19 deaths in children and young people in England, March 2020 to December 2021: an active prospective national surveillance study

A new study conducted in England shows that the risk of death due to COVID-19 remains very low for children and young people, and most deaths occur in those with underlying health conditions. A new study conducted in England shows that the risk of death due to COVID-19 remains very low for children and young

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New drug can successfully treat patients typically resistant to high blood pressure treatment

A new drug called Baxdrostat has been shown to significantly reduce high blood pressure (hypertension) in patients who may not respond to current treatments for the condition, according to results from a phase II trial led jointly by a Queen Mary University of London researcher and colleagues at CinCor Pharma, USA. Published in the New England

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Intravenous iron improved long-term outcomes for people with heart failure and iron deficiency

Research Highlights: Repeated intravenous (IV) administration of iron reduced the risk of hospitalization for heart failure and cardiovascular death in people with heart failure and iron deficiency, according to a clinical trial in the United Kingdom. Treatment with IV iron was safe and well-tolerated, and people who received it reported improved well-being based on quality-of-life

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Novel CRISPR/Cas9-based gene-editing therapy shows promise for patients with transthyretin amyloid cardiomyopathy

A single IV infusion of NTLA-2001, a novel CRISPR/Cas9-based gene editing therapy, significantly reduced circulating transthyretin (TTR) protein levels in patients with ATTR amyloid cardiomyopathy, a progressive and fatal cause of heart failure, according to late-breaking research presented today at the American Heart Association’s Scientific Sessions 2022. The meeting, held in person in Chicago and

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Organoids Reveal How SARS-CoV-2 Damages Brain Cells — and a Potential Treatment

COVID-19 infections can result in long-lasting neurological symptoms; new research suggests an already approved anti-viral may inhibit viral replication and rescue impaiOrganoids Reveal How SARS-CoV-2 Damages Brain Cells — and a Potential Treatmentred neurons Using human brain organoids, an international team of researchers, led by scientists at University of California San Diego School of Medicine

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Over 350 Multidisciplinary Experts from More than 100 Countries Reach Consensus on How to End COVID-19 as a Public Health Threat

A new global COVID-19 study provides actionable recommendations to end the public health threat without exacerbating socio-economic burdens or putting the most vulnerable at greater risk SARS-CoV-2 continues to circulate among us. Although some governments have moved on, a new study published today in the journal Nature says that specific efforts and resources are still required to save

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Study shows GABA, an inexpensive and readily available chemical, reduces disease severity, lung viral load and death in SARS-CoV-2-infected mice

Preclinical studies in mice that model human COVID-19 suggest that an inexpensive, readily available amino acid might limit the effects of the disease and provide a new off-the-shelf therapeutic option for infections with SARS-CoV-2 variants and perhaps future novel coronaviruses. A team led by researchers at the David Geffen School of Medicine at UCLA report that an

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CAR-T cells therapy for autoimmune diseases

A recent study published in the journal Nature Medicine highlights the potential of CAR T therapy beyond this realm—specifically for lupus and other autoimmune diseases. What is Lupus? Lupus (systemic lupus erythematosus) is an autoimmune disease that affects women approximately ten more than men, and is characterized by the overproduction of antibodies that attack the body’s own tissues. Lupus

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‘A silent killer’ – COVID-19 shown to trigger inflammation in the brain

Research led by The University of Queensland has found COVID-19 activates the same inflammatory response in the brain as Parkinson’s disease. The discovery identified a potential future risk for neurodegenerative conditions in people who’ve had COVID-19, but also a possible treatment. The UQ team was led by Professor Trent Woodruff and Dr Eduardo Albornoz Balmaceda from UQ’s School of Biomedical Sciences,

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Getting to the heart of COVID-19 vaccination and its cardiovascular risks

After mRNA vaccination, adults under 40 have a slightly greater chance of developing myocarditis or pericarditis, yet the vaccine’s benefits outweigh the risks, according to the American Journal of Preventive Medicine A comprehensive review and meta-analysis of published research confirm that young adults (40 years old and younger) have a slightly elevated risk for myocarditis

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Long COVID and pulmonary fibrosis better understood thanks to innovative techniques

An international team of researchers has revealed how scarring occurs in Long-COVID and pulmonary fibrosis using innovative blood biomarkers and X-ray technology. This study, published in The Lancet – eBioMedicine, contributes to the knowledge on the pathophysiology of severe COVID-19 and thus its treatment. Long-COVID syndrome, or the origin of the long-term consequences of SARS-CoV-2

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Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

 New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) found that different skeletal stem cell (SSC) populations contribute to repair of different kinds of bone injuries. In the study, published in Cell Stem Cell, researchers identified distinct cell markers that allowed them to track SSCs in the bone marrow inside of bones versus SSCs in the

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University of Michigan researchers engineer a drug derived from bananas showing promise in fighting deadly viruses and SARS-CoV-2

A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests. And the process used to create the virus-fighting form may help scientists develop even more drugs, by harnessing the “sugar code”

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For American Society of Anesthesiologists statins lower COVID-19 severity and risk of death

Commonly used cholesterol-lowering statins may reduce the risk of death and severity of COVID-19 disease, suggests a study of more than 38,000 patients being presented at the Anesthesiology 2022 annual meeting. “While there is no ‘magic bullet’ to help patients who are very ill with COVID-19, statins decrease inflammation, which may help reduce the severity

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The Philippines Department of Health said first new cases of XBB and XBC Covid-19 Omicron variants were detected. 

In a media briefing, Health Officer-in-Charge Maria Rosario Vergeire said that based on the latest whole genomic sequencing run of the agency, a total of 81 XBB subvariant cases have been detected in two regions in the country.  Vergeire also said that there were 193 XBC subvariant cases found in 11 out of 17 regions

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In Singapore XBB seems to be more prevalent in the COVID-naive and those originally infected in the Delta and pre-Delta era

Singapore’s Health Minister, Ong Ye Kung, has said that he expects the current XBB SARS-CoV-2 wave to peak in mid-November 2022.  In an assured press conference, Singapore’s Health Minister said he expects the XBB to crest at about 15,000 daily cases on average. Covid case levels in Singapore are currently averaging around 8,500 a day.

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Intranasal COVID-19 AstraZeneca vaccine candidate’s Phase I trial clinical data highlights need for further development

Researchers from the University of Oxford have today reported new findings from a Phase 1 clinical trial studying the safety and immune response of an intranasally-administered vaccine against COVID-19.The study was performed at the University in collaboration with AstraZeneca and used the same vaccine based on the ChAdOx1 adenovirus vector, as is already licensed for

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3D-bioprinted human tissues and the path toward clinical translation

Three-dimensional bioprinting is an emerging technology that has the potential to build human tissue, on demand, to treat a wide range of human diseases. However, bridging the gap from research at the benchtop to clinical translation requires a host of resources, time, and energy. A new Science Translational Medicine perspective authored by researchers in Carnegie Mellon University’s

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Antibodies bite worse on new omicron BA.2.75.2 variant: a study from the Karolinska Institutet shows.

A study from the Karolinska Institutet shows that the coronavirus variant BA.2.75.2, a subvariant of omicron, more easily bypasses neutralizing antibodies in the blood and is resistant to several monoclonal antibody treatments. This means an increased risk of sars-cov-2 infection this winter, unless the new updated bivalent vaccines can strengthen the immunity of the population. The results

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First stem cell treatment for spina bifida delivered during fetal surgery performed at UC Davis Health

Groundbreaking trial aims to reverse the paralysis and other abnormal functions of spina bifida before birth Three babies have been born after receiving the world’s first spina bifida treatment combining surgery with stem cells. This was made possible by a landmark clinical trial at UC Davis Health.   The one-of-a-kind treatment, delivered while a fetus is

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SARS-CoV-2 Infects Neurons and Induces Inflammation in the Brains of Rhesus Macaques

SARS-CoV-2, the COVID-19 virus, caused significant neuron damage and inflammation within a week of infection in rhesus macaque monkeys, according to a new study. The researchers from the California National Primate Research Center at the University of California, Davis, also discovered that aged monkeys with Type 2 diabetes experienced worse virus-induced neurological damage. The findings,

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CART cells for relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b–2, open-label study on health-related quality of life published in The Lancet Haematology

CARTITUDE-1 is a phase 1b–2 study evaluating ciltacabtagene autoleucel (cilta-cel), a chimeric antigen receptor T cell therapy with two B-cell maturation antigen–targeting single-domain antibodies, in patients with relapsed or refractory multiple myeloma. Primary efficacy outcomes have previously been reported. In this paper are reported health-related quality of life (HRQOL) secondary outcomes evaluated using patient-reported outcomes.

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Results of a phase 1 UCART19 trial, a first-in-class allogeneic anti-CD19 CART-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM) published in The Lancet Haematology

The prognosis for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia remains poor. UCART19, an allogeneic genome-edited anti-CD19 chimeric antigen receptor (CAR) T-cell product derived from healthy donors and available for immediate clinical use, offers a potential therapeutic option for such patients. The CALM trial is a first-in-human study evaluating the safety and antileukaemic

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SARS-CoV-2 origin: the evidence towards zoonosis is overwhelming: experts panel conclusions in PNAS. One Health approach is necessary to diminish zoonosis threats.

“Smart surveillance” for viral spillover from animals to humans, targeted preparedness and drug and vaccine research, and worldwide cooperation on surveillance and stopping disease spread are required to reduce deaths and lessen the economic consequences of the next pandemic, according to an international team of scientists. In a perspective article published this week in Proceedings of

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XBB, SARS CoV-2 variant detected in Singapore and Hong Kong, is significantly more immune evasive than BA.2.75.2 and BQ.1.1 

A fantastic diagram by Daniele Focosi showing the convergent evolution that has led to the lineages we have been discussing recently, including BQ.1.1, CA.1, BR.2 and the new XBB variant. The speed with which SARS-CoV-2 is now evolving is quite breathtaking – ever-fitter variants are now being uncovered on an almost daily basis. Just over one week

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Colonoscopy unfortunately is not a miracle cure for colorectal cancer. According to study published inNEJM is not better than the fecal samples

On October 10 the world’s first randomized study on using colonoscopy-screening to prevent colorectal cancer was presented during the 2022 United European Gastroenterology Week in Vienna. The full study was also published in New England Journal of Medicine. “Colonoscopy unfortunately is not a miracle cure for colorectal cancer. According to our study, it probably is not better

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A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets: a Cleveland Clinic study finds.

A Cleveland Clinic-led research team used artificial intelligence to map out hundreds of ways that the virus that causes COVID-19 interacts with infected cells. Through this analysis, they identified potential COVID-19 medicines within thousands of drugs already approved by the FDA for other treatments. The research focused on host-targeting therapies, which operate differently from other

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Gene Therapy Rapidly Improves Night Vision in Adults with Congenital Blindness, Penn Study Finds

Patients’ low-light sensitivity improved by factors of thousands in a clinical trial Adults with a genetic form of childhood-onset blindness experienced striking recoveries of night vision within days of receiving an experimental gene therapy, according to researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania. The patients

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Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021

Women and people who needed to be hospitalized with Covid are much more likely to develop long Covid, according to a new peer reviewed study published in JAMA on Monday, offering new insight into the persistent and sometimes disabling condition as researchers push to develop new treatments and cures. KEY FACTS An estimated 6% of people with symptomatic Covid infections develop

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Study Provides Further Evidence That Immune Cell Dysregulation is a Driver of COVID-19 Severity

Maintenance of reparative lung macrophages may be a viable therapeutic strategy for the treatment of SARS-CoV-2 and other inflammatory lung diseases In one of the largest single-center COVID-19 cohort studies to date, researchers at the Icahn School of Medicine at Mount Sinai, using samples collected during the peak of the pandemic in New York City,

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 Short documentary video from the New England Journal of Medicine on Sickle Cell Disease and Gene Therapy from Patient and Physician Perspectives

In this short documentary video from the New England Journal of Medicine, patients and physicians partner both to highlight the experience of living with sickle cell disease and to discuss the pathophysiology of the disease and new treatment strategies, including gene therapy. Patients share their own stories of interactions with the health care system and explore

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Coffee drinking is associated with increased longevity: a study of European Society of Cardiology finds.

Drinking two to three cups of coffee a day is linked with a longer lifespan and lower risk of cardiovascular disease compared with avoiding coffee, according to research published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology. The findings applied to ground, instant and decaffeinated varieties. “In this large, observational

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Calibr, a Division of Scripps Research, reports promising results from first-in-human clinical trial of switchable CAR-T (CLBR001 + SWI019), a next-generation universal CAR-T platform designed to enhance the versatility and safety of cell therapies

In preliminary results from a Phase I study of CLBR001 + SWI019 for patients with B cell malignancies: 7 of 9 patients responded and 6 of 9 had a complete response (78% ORR, 67% CR) CLBR001 cells engrafted at higher levels than approved CAR-T cell products without causing an increase in the incidence of CRS

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Ecological niche modelling analyses highlight a risk of expansion of Lassa virus towards Central and East Africa potentially leading to a drastic increase in the number of people exposed.

In the study, which appeared on September 27 in Nature Communications, scientists analyzed decades of environmental data associated with Lassa virus outbreaks, revealing temperature, rainfall and the presence of pastureland areas as key factors contributing to viral transmission. The researchers projected that areas hospitable to Lassa virus spread may extend from West Africa into Central and

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New study of Case Western Reserve University: Risk factor for developing Alzheimer’s disease increases by 50-80% in older adults who caught COVID-19

Older people who were infected with COVID-19 show a substantially higher risk—as much as 50% to 80% higher than a control group—of developing Alzheimer’s disease within a year, according to a study of more than 6 million patients 65 and older. In a study published in the Journal of Alzheimer’s Disease, researchers report that people 65

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New University of California Irvine-led report Illustrates potential of precision genome editing in treating inherited retinal diseases

Improvements in technology and delivery techniques could revolutionize treatment of genetic disorders of vision In a new paper, University of California, Irvine researchers explain how precision genome editing agents have enabled precise gene correction and disease rescue in inherited retinal diseases (IRDs). The study, titled, “Precision genome editing in the eye,” was published this week

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Disarming the neutrophils induced lethal lung response through PTP1B inhibitors which regulate CXCR4 signaling

The Takeaway Neutrophils are the body’s first line of defense against infection. But if too many attack for too long, they can damage the tissues they’re meant to protect. In the lungs, this damage can lead to acute respiratory distress syndrome, the leading cause of death due to COVID-19. CSHL researchers have found that using

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COVID-19 mutations accelerated by virus-fighting enzyme in human cells, according to new research

The findings by a team of USC researchers could help scientists predict new coronavirus variants and subvariants and give them a leg up on producing effective vaccines. Researchers have found the first experimental evidence explaining why the COVID-19 virus produces variants, such as delta and omicron, so quickly. The findings, published Sept. 13 in the journal Scientific Reports,

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At least 17 million people in the WHO European Region experienced long COVID in the first two years of the pandemic; millions may have to live with it for years to come

WHO/Europe urges countries to take post COVID-19 condition seriously by urgently investing in research, recovery, and rehabilitation New modelling conducted for WHO/Europe by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington’s School of Medicine in the United States shows that in the first two years of the pandemic, at least

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NIH research : Bronchodilators don’t improve smoking-related respiratory symptoms in people without COPD

Researchers supported by the National Institutes of Health have found that dual bronchodilators – long-lasting inhalers that relax the airways and make it easier to breathe – do little to help people who do not have chronic obstructive pulmonary disease (COPD), but who do have respiratory symptoms and a history of smoking.    COPD, a lung disease

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How the gut may help to drive COVID-19

New findings from Flinders University have demonstrated a molecular link between COVID-19 and serotonin cells in the gut. The research could help provide further clues to what could be driving COVID-19 infection and disease severity and supports previous evidence that antidepressants, known as selective serotonin reuptake inhibitors (SSRIs), could reduce the severity of COVID symptoms.

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FDA Approves First Cell-Based Gene Therapy to Treat Adult and Pediatric Patients with Beta-thalassemia Who Require Regular Blood Transfusions

The U.S. Food and Drug Administration approved Zynteglo (betibeglogene autotemcel), the first cell-based gene therapy for the treatment of adult and pediatric patients with beta-thalassemia who require regular red blood cell transfusions.  “Today’s approval is an important advance in the treatment of beta-thalassemia, particularly in individuals who require ongoing red blood cell transfusions,” said Peter

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The enzyme ceramidase inhibition by Fluoxetine emerges as a new potential therapy of Covid-19

Fluoxetine, a common antidepressant, inhibits the SARS-CoV-2 coronavirus in cell cultures and in preparations from human lung tissue. This was demonstrated by researchers at Julius-Maximilians-Universität (JMU) Würzburg in the summer of 2020. However, the mechanism of this inhibition was utterly unclear, so the teams continued their research. To this end, they developed the molecule AKS466,

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Cedars-Sinai Study: Most People Infected With Omicron Didn’t Know It

Cedars-Sinai Researchers Find 56% Were Unaware They Were Infected With Omicron Variant of SARS-CoV-2 The majority of people who were likely infected with the Omicron variant of SARS-CoV-2, the virus that causes COVID-19, didn’t know they had the virus, according to a new study from Cedars-Sinai investigators. The findings are published in JAMA Network Open. “More

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Targeting TYMP Gene with Tipiracil could help fight thrombosis in COVID-19 patients

Findings from a new study at the Marshall University Joan C. Edwards School of Medicine show that a thymidine phosphorylase (TYMP) inhibitor could help slow thrombosis in COVID-19 patients. Expression of TYMP, the gene that plays an important role in platelet activation, thrombosis and inflammation, is significantly increased in COVID-19 patients. The increase of TYMP

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Stem cell-based therapy for human diseases: a complete review

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types

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Higher risk of vein blood clots in COVID vs flu patients

Hospitalized adult COVID-19 patients before and after SARS-CoV-2 vaccine availability had significantly higher odds of venous—but not arterial—thromboembolism than those hospitalized for influenza before the pandemic, finds a study published today in JAMA. A team led by University of Pennsylvania researchers retrospectively studied rates of venous thromboembolism (blood clot in a vein) and arterial thromboembolism (blood clot in

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Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population

The results of a retrospective cohort study from the TriNetX US collaborative networks are published in eClinicalMedicine Background The long-term cardiovascular outcomes in COVID-19 survivors remain largely unclear. The aim of this study was to investigate the long-term cardiovascular outcomes in COVID-19 survivors. Methods This study used the data from the US Collaborative Network in

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UT Southwestern researchers identify mechanism crucial for COVID-19 virus replication

Findings could lead to new strategies to treat COVID-19 infections A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that’s critical for successful viral replication. The finding, published in Nature, could lead to new strategies to attack COVID-19, which has sickened nearly 600

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Clinical Practice Guidelines from the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma

The Association for the Advancement of Blood and Biotherapies (AABB) has released clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma (CCP) in hospital and outpatient settings. Based on two living systematic reviews of randomized controlled trials (RCTs), the guidelines provide five specific recommendations for treating patients with COVID-19 and suggest that CCP

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The US and UK Government Release Reports on Long COVID to Support Patients and Further Research

The US Government is committed to helping people across America affected by Long COVID. In April, President Joe Biden issued a Memorandum on Addressing the Long-Term Effects of COVID-19, which called for the creation of two reports. Within 120 days, the U.S. Department of Health and Human Services (HHS), leading a whole-of-government response, developed two reports that

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Two patients treated with Novartis Zolgensma gene therapy died due to acute liver injury.

Two children who received a Novartis gene therapy for their neuromuscular disease died following treatment, spotlighting its risks and renewing questions about the safety of genetic medicines like it. The patients developed acute liver failure between five and six weeks after infusion with the gene therapy, called Zolgensma and approved to treat spinal muscular atrophy,

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66,000 people in Southeast Asia may be infected with bats SARS-related coronaviruses every year: results of a study published in Nature Communications

New research offers risk assessment that estimates the risk of human infections from SARS-related coronaviruses originating in 23 bat host species across Southeast Asia In a new study led by EcoHealth Alliance and published in Nature Communications, researchers estimate that more than 66,000 people in Southeast Asia are directly infected each year with SARS-related coronaviruses (SARSr-CoV) originating in

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COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron)

A model of COVID-19 dynamics in South Africa reveals epidemiological characteristics of the main SARS-CoV-2 variants of concern and highlights their potential to cause further outbreaks. Published in eLife, the researchers’ findings highlight the need for more proactive planning and preparedness for future variants of concern (VOCs), including the development of a universal vaccine that can

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Inhaled aprotinin reduces viral load in mild-to-moderate inpatients with Covid-19: paper published in European Journal of Clinical Investigation

New variants of the causative pathogen, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continue to emerge, and the ‘new normal’ appears to be a scenario where human beings coexist with the virus. However, many individuals are at higher risk of severe COVID-19 due to comorbidities like obesity, hypertension, type 2 diabetes mellitus, advancing age,

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Acute hepatitis of unknown origin in children: an update by the European Reference Network ERN RARE-LIVER

Unexplained cases of acute liver inflammation in children, especially in the United Kingdom (UK) were reported earlier this year. In response, the European Reference Network on Hepatological Diseases (ERN RARE-LIVER) conducted a thorough investigation that did not confirm the alarming observation from the UK in other European countries. However, an infectious cause remains the main suspected

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Higher doses of CAR T cell therapy associate with improved outcomes in young patients with B-ALL : a report from the pediatric real-world CAR consortium

Young people who received doses of tisagenlecleucel, a chimeric antigen receptor T cell (CAR-T) therapy, at the higher end of the FDA-approved dosing range had significantly better survival rates at one year compared with those who received lower doses within this range, according to research published today in Blood Advances.   Since its approval as the first

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Pfizer-BioNTech Vaccine Targeting Fast-Spreading Omicron BA.1 and BA.4/5 will be delivered as soon as October 2022

Pfizer and BioNTech will begin trials of their updated mRNA Covid-19 vaccine designed to protect against the newer BA.4 and BA.5 sub-variants of the coronavirus latest this month, BioNTech announced on Monday, joining other vaccine makers like Moderna who are trying to create updated shots targeting the faster spreading and immune evasive variants. The trial

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Dysregulation of the kallikrein-kinin system and neutrophils role in bronchoalveolar lavage fluid of patients with severe COVID-19

Results published by University of Leuven researchers in eBioMedicine Markers of inflammation and coagulation are predictors for clinical outcomes in patients with COVID-19. Binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the angiotensin converting enzyme 2 receptor, which is involved in kinin breakdown, could interfere with the kallikrein-kinin pathway. SARS-CoV-2 induced dysregulation

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12,7% COVID-19 patients develop long COVID symptoms: results of a large Dutch study

One in eight adults (12.7%) who are infected with SARS-CoV-2 experience long term symptoms due to COVID-19, suggests a large Dutch study published in The Lancet. The study provides one of the first comparisons of long-term symptoms after SARS-CoV-2 infection (often called ‘long COVID’) with symptoms in an uninfected population, as well as measuring symptoms in

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St. Jude Researchers improved CAR T-cell therapy for T-cell acute lymphoblastic leukemia

Scientists at St. Jude Children’s Research Hospital developed a simple method to select for more effective cancer-destroying CAR T cells for patients with relapsed T-ALL. Scientists at St. Jude Children’s Research Hospital are improving chimeric antigen receptor (CAR) T-cell therapy. Their new simplified approach selected for an advantageous T-cell type and showed promise in the lab against relapsed T-cell

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Gene Therapy Approach Shows Promise in Treating ALS

In rodent models, introduced neuroprotective protein slowed disease progression and increased life span Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control. In a new study, published July 11, 2022 in the journal Theranostics, researchers at

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Getting more exercise than guidelines suggest may lower death risk as much as 31%.

Doubling to quadrupling the minimum amount of weekly physical activity recommended for U.S. adults may substantially lower the risk of dying from cardiovascular disease and other causes, new research finds. The study, published Monday in the American Heart Association journal Circulation, found people who followed the minimum guidelines for moderate or vigorous long-term, leisure physical activity

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Vitamin D supplements data on fractures prevention are inconsistent: results of the VITAL trial in NEJM.

More research suggests it’s time to abandon the craze over vitamin D. Taking high doses of “the sunshine vitamin” doesn’t reduce the risk of broken bones in generally healthy older Americans, researchers reported Wednesday on NEJM . It’s the latest in a string of disappointments about a nutrient once hoped to have wide-ranging protective effects. That same

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Prognosis and persistence of smell and taste dysfunction in 5% patients with Covid-19: meta-analysis results published in The BMJ

About 5% of adults may develop long-lasting changes to their sense of smell or taste after COVID-19 infection, suggests research published by The BMJ today. With more than 550 million confirmed COVID-19 cases to date, this means that at least 15 million and 12 million adult patients may experience long-term smell and taste deficiencies, respectively. Given the

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SARS-CoV-2 Variants Have Developed Resistance to Human Interferons

CU Anschutz researchers examined how five SARS-CoV-2 variants interact with diverse interferons and found the virus has adapted to evade this important front-line defense of the innate immune system Researchers at the University of Colorado Anschutz Medical Campus have investigated how antiviral proteins called interferons interact with SARS-CoV-2, the cause of COVID-19. The study, published in Proceedings

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The third COVID-19 booster was crucial to identifying and fighting new variants

Twenty different COVID-19 variants were effectively identified and neutralised after the third booster, according to the new study for which the University of Surrey provided the crucial antigenic map of variants of concern.  While the study’s results suggested that immunity decreases 20 weeks after vaccination, the third booster (of the Pfizer-BioNTech vaccine, in the case

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Primary thromboprophylaxis in symptomatic outpatients with COVID-19: no benefit in two randomized trials 

Two trials show no differences between patients who received enoxaparin vs standard of care The routine use of antithrombotic therapies to prevent thromboembolic complications provided no benefit for symptomatic outpatients with COVID-19, according to the results of two randomized trials. In the OVID trial, the 30-day risk of hospitalization and death was similar among patients who

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Private clinics in Cyprus, Germany and Switzerland are offering expensive unproven “blood washing” procedures for abroad Long Covid patients

Thousands of people experiencing the debilitating symptoms of long covid are traveling abroad to seek costly but unproven treatments such as “blood washing”, according to an investigation carried out by The BMJ and ITV News released today. Patients are traveling to private clinics in Cyprus, Germany and Switzerland for apheresis – a blood-filtering treatment normally

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Acute and post-acute COVID-19 presentations in athletes: a systematic review and meta-analysis shows that 8% of athletes have persistent symptoms after contracting COVID-19

Researchers at the University of São Paulo (USP) in Brazil analyzed data from 43 scientific articles describing the effects of COVID-19 on athletes and concluded that while the disease was asymptomatic or mild in the vast majority of cases (94%), about 8% of the subjects concerned had persistent symptoms affecting their performance and potentially preventing

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New paper from Cleveland University Hospitals examines transfusion utilization and appropriateness: thinking differently at a tertiary academic medical center

Researchers find decrease in transfusions, increase in appropriate use, and savings of $2.5 million In a new paper, researchers from University Hospitals (UH) detail how they used data via a dashboard to decrease the use of packed red-blood cell (pRBC) transfusions and platelets with an increase in appropriate transfusions.Their paper, “Transfusion Utilization and Appropriateness: Thinking Differently

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A new study confirms convalescent plasma doesn’t benefit severely ill patients hospitalized with COVID-19

Convalescent plasma, widely given to severely ill patients hospitalized with COVID-19 during the pandemic, does not improve their ability to survive or recover, according to a national clinical trial led by Vanderbilt University Medical Center and published in the journal CHEST. The multicenter blinded, randomized placebo-controlled, Passive Immunity Trial for our Nation (PassITON), looked at the

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COVID-19 virus spike protein flexibility improved by human cell’s own modifications

When the coronavirus causing COVID-19 infects human cells, the cell’s protein-processing machinery makes modifications to the spike protein that render it more flexible and mobile, which could increase its ability to infect other cells and to evade antibodies, a new study from the University of Illinois Urbana-Champaign found. The researchers created an atomic-level computational model

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Small NIH study reveals how immune response triggered by COVID-19 may damage the brain

Findings could give insight into long-term neurological symptoms of COVID-19 A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain’s blood vessels and may lead to short- and long-term neurological symptoms. In a study published in Brain, researchers from the National Institute of Neurological Disorders and

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Charité researchers simulate coronavirus infection using human lungs and organoids

A team of Berlin-based researchers have simulated SARS-CoV-2 infection in human lungs, thereby generating key insights into the mechanisms involved. Using cultured lung tissue samples, the researchers showed that the virus responsible for COVID-19 has only limited capacity for directly infecting cells within human alveoli. The majority of viruses which reach the lungs are ingested by macrophages (cells of

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Efficacy and safety of CD19-specific CAR T cell–based therapy in B-cell acute lymphoblastic leukemia patients with CNSL

CNS relapse is still a common cause of treatment failure in R/R B-ALL, although chemotherapy, cranial irradiation, and allo-HSCT are all modalities that can be incorporated into the management of CNSL. In the present study, published on Blood by a team of Xuzhou Medical University, was reported the efficacy, toxicity, and clinical feasibility of CD19-specific

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First successful treatment of severe pulmonary hypertension using umbilical cord stem cells

Hannover Medical School doctors successfully treat three-year-old girl / Publication in “Nature Cardiovascular Research“ Clinical researchers at Hannover Medical School (MHH) have succeeded for the first time worldwide in stopping the usually fatal course of the disease in severe pulmonary hypertension thanks to a novel therapeutic approach. A three-year-old girl suffering from so-called pulmonary arterial

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Colorado University New Study Paves Way to Better Understanding and Treating Long COVID

Researchers are first to link COVID-specific T Cells to lung function, Long COVID A new study published in today’s issue of PLoS Pathogens is the first to link SARS-CoV-2 specific T cells to lung function and those who suffer from long-term COVID symptoms. Long COVID currently affects hundreds of millions of Americans. The study found that patients suffering

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Heart Failure Patients Unvaccinated Against COVID-19 Are Three Times More Likely to Die From It Than Boosted Heart Failure Patients

Mount Sinai study shows dramatic protective effects of vaccination in this high-risk population, which often demonstrates vaccine hesitancy Heart failure patients who are unvaccinated against SARS-CoV-2, the virus that causes COVID-19, are three times more likely to die if infected with the virus compared to fully boosted heart failure patients, according to new research out

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People in US Republican Counties Were More Likely to Die From COVID-19, University of Maryland-led Analysis Shows

The partisan divide in the United States throughout the COVID-19 pandemic has stretched beyond differences in attitudes about masking, social distancing and vaccines. According to a new study led by a University of Maryland researcher, it also is tied to a clear difference in mortality rates from the virus. In the study, published today in Health

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Growing US ‘Mortality Gap’ Detected Between Republican and Democratic Counties

A new study highlights how closely connected politics and health outcomes have grown over time. Investigators from Brigham and Women’s Hospital examined mortality rates and federal and state election data for all counties in the U.S. from 2001 to 2019. The team found what they call a “mortality gap” — a widening difference between age-adjusted death rates

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Recent progress in cell therapy research: a review in Nature outlines engineering disciplines, genome and epigenome editing, synthetic biology and biomaterial-mediated immune modulation.

Given recent progress in cell therapy research, it is clear that the engineering disciplines outlined in this Review will play an increasing role in the creation of new product pipelines with improved safety, efficacy and accessibility for patients. Recent scientific advances have not only demonstrated the potential impact of technologiesdeveloped by each of these fields,

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Study: Patients with severe COVID-19 pneumonia treated with leukotriene inhibitors are more likely to survive, University of Buffalo researchers find

In a retrospective study based on big data, the researchers found that Leukotriene Inhibitors (LTI)s prevented death in COVID-19 patients with low oxygen saturation University at Buffalo biomedical informatics researchers have found that patients hospitalized with COVID-19 pneumonia had a 13.5% survival advantage when treated with a combination of leukotriene inhibitors (LTIs) and the steroid

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‘Cell pores’ discovery and a new drug give hope to millions of brain and spinal cord injury patients

Scientists from the University of Birmingham have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord. Their research, published today in Clinical and Translational Medicine, demonstrates that AZD1236, a drug developed by AstraZeneca, can significantly reduce “secondary damage” caused by the body’s response to spinal

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Amyloid production induced by neutrophil elastase as possible mechanism behind enigmatic symptoms in Severe Covid-19

In severe covid-19 and long-term covid, disorders of blood coagulation often occur. Now, researchers at LiU have discovered that the body’s immune system can affect the nail protein on the surface of the sars-cov-2 virus so that it forms misfolded protein, so-called amyloid. The findings point to a possible link between harmful amyloid formation and covid-19 symptoms.

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BWH Scientists Develop ‘Off the Shelf’ Engineered Stem Cells to Treat Aggressive Glioblastoma

Glioblastomas (GBMs) are highly aggressive cancerous tumors of the brain and spinal cord. Brain cancers like GBM are challenging to treat because many cancer therapeutics cannot pass through the blood-brain barrier, and more than 90 percent of GBM tumors return after being surgically removed, despite surgery and subsequent chemo- and radiation therapy being the most

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University of Minnesota technology allows amputees to control a robotic arm with their mind

Research team makes mind-reading possible with electronics and AI University of Minnesota Twin Cities researchers have developed a more accurate, less invasive technology that allows amputees to move a robotic arm using their brain signals instead of their muscles.  Many current commercial prosthetic limbs use a cable and harness system that is controlled by the

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90-Day Clinical Outcome of Critically Ill Hospitalized Covid-19 Patients Treated with Imatinib: lower mortality rate, shorter duration of invasive ventilation and more ventilator free days.

Patients with severe COVID-19 who were given imatinib had lower mortality rates at 90-day follow-up, according to research published at the ATS 2022 international conference. The study investigated the long-term efficacy of imatinib in hospitalized COVID-19 patients in the Netherlands as part of the randomized, double-blind, placebo-controlled CounterCOVID study. A tyrosine kinase inhibitor, imatinib is currently an oncology

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Identifying who has long COVID in the USA: a machine learning approach using N3C data

Using machine learning, researchers find patterns in electronic health record data to better identify those likely to have the condition. Long COVID is marked by wide-ranging symptoms, including shortness of breath, fatigue, fever, headaches, “brain fog” and other neurological problems. Such symptoms can last for many months or longer after an initial COVID-19 diagnosis. One

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SARS-CoV-2 superantigens could be involved in Severe acute pediatric hepatitis, following a letter on The Lancet Gastroenterology & Hepatology

Recently, there have been reports of children with a severe acute form of hepatitis in the UK, Europe, the USA, Israel, and Japan.  Most patients present with gastrointestinal symptoms and then progress to jaundice and, in some cases, acute liver failure. So far, no common environmental exposures have been found, and an infectious agent remains

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New type of cell therapy can repair damaged heart tissue after infarction

Researchers at Karolinska Institutet, Technical University of Munich (TUM) in Germany and AstraZeneca, among others, have identified a new type of cell therapy with the potential to heal injuries to the heart after a heart attack. The preclinical study, published in the journal Nature Cell Biology, shows that so-called ventricular progenitor cells can stimulate the heart’s

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FDA’s Center for Drug Evaluation and Research (CDER) Launches New Accelerating Rare disease Cures (ARC) Program

FDA’s Center for Drug Evaluation and Research (CDER) has announced the launch of the new Accelerating Rare disease Cures (ARC) Program. The goal of the CDER ARC Program is to speed and increase the development of effective and safe treatment options addressing the unmet needs of patients with rare diseases. Launched in May 2022, CDER’s Accelerating Rare disease

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Feces of people with mild COVID can harbor viral genetic material months after infection: can it be responsible for Long Covid ?

People with mild to moderate COVID-19 can shed viral RNA in their feces months after initial infection, Stanford researchers find. Those who do often have nausea, vomiting and abdominal pain. If you’re relying on nasal or throat-based tests to give you a clean bill of health after a COVID-19 infection, you might be swabbing the

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Novel Supramolecular CRISPR–Cas9 Carrier Enables More Efficient Genome Editing

Fifth generation polyrotaxane (PRX) carriers can effectively deliver CRISPR-Cas9 ribonucleoproteins (RNPs) The PRX carrier can cross the cell membrane, avoid endosomal action, and release Cas9 RNP for entry into the nucleusImage courtesy: Kumamoto University, The carriers, aminated polyrotaxanes, can flexibly and reversibly bind with Cas9 ribonucleoprotein and protect it from intracellular endosomal degradation CRISPR-Cas9 is

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A new study published in JAMA Psychiatry suggests neuropsychiatric sequelae similar for severe COVID-19 and Severe Acute Respiratory Infection

The neuropsychiatric sequelae are similar for severe COVID-19 infection and for other severe acute respiratory infections (SARI), according to a study published online May 11 in JAMA Psychiatry. Ashley Kieran Clift, M.B.B.S., from the University of Oxford in the United Kingdom, and colleagues quantified the risks of new-onset neuropsychiatric conditions and new neuropsychiatric medication prescriptions after discharge from

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A Lancet follow-up study shows half of people hospitalized with COVID-19 have at least one symptom two years after infection

Two years after infection with COVID-19, half of patients who were admitted to hospitals still have at least one symptom, according to the longest follow-up study to date, published in The Lancet Respiratory Medicine. The study followed 1,192 participants in China infected with SARS-CoV-2 during the first phase of the pandemic in 2020. While physical and

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Lloviu virus, a new possible zoonotic pandemic threat isolated for the first time in European bats

Researchers from the Medway School of Pharmacy (a partnership between the universities of Kent and Greenwich) have helped isolate the Lloviu virus (LLOV) – a close relative of Ebola virus – for the first time, highlighting the need for future research to ensure pandemic preparedness. LLOV is part of the filovirus family – which includes the Ebola

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The death of the patient transplanted with gene-edited pig heart could be due to a porcine Cytomegalovirus

The pig heart transplanted into an American patient earlier this year in a landmark operation carried a porcine virus that may have derailed the experiment and contributed to his death two months later, say transplant specialists. David Bennett Sr. was near death in January when he received a genetically edited pig heart in a pioneering between-species transplant

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Inspection at the IHU-Méditerranée Infection and the AP-HM: the French National Agency for Medicines Safety (ANSM) takes legal action again and initiates administrative proceedings

ANSM is publishing the final reports of the inspection conducted at the Institut hospitalo universitaire-Méditerranée Infection de Marseille (IHU) and at the Assistance Publique – Hôpitaux de Marseille (AP-HM), following reports in the context of our whistleblower system. The inspection reveals serious shortcomings and non-compliances with the regulations for research involving the human person (RIPH) , in particular

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Nearly 13 Percent of COVID-19 Hospitalized Patients Had Serious Neurologic Symptoms

Overwhelming evidence shows that infection with severe acute respiratory syndrome (SARS-CoV-2) causes dysfunction of multiple organ systems, including the nervous system. Neurologic symptoms are frequently reported even in patients with mild illness and for some, these neurologic symptoms may persist as part of long-haul COVID. To describe the prevalence, associated risk factors and outcomes of

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Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C

Researchers have discovered the blood clotting and immune protein pathways that are activated in severe cases of COVID-19 in children, paving the way for earlier diagnosis and more targeted treatments. The study led by the Murdoch Children’s Research Institute (MCRI) and the University of Melbourne and published in Nature Communications, has identified disease mechanisms in children with COVID-19

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Acute Hepatitis and Adenovirus Infection Among Children No Covid link found by CDC in Alabama cases

During October–November 2021, clinicians at a children’s hospital in Alabama identified five pediatric patients with severe hepatitis and adenovirus viremia upon admission. In November 2021, hospital clinicians, the Alabama Department of Public Health, the Jefferson County Department of Health, and CDC began an investigation. This activity was reviewed by CDC and conducted consistent with applicable

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Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection

If you have Covid-19 symptoms but test negative with a rapid antigen test, you should test again 1-2 days later, or on day four of feeling crook, new research suggests. A study out of the United States, conducted between January-May 2021 and published in JAMA Internal Medicine on Saturday, compared the PCR and RAT results of 225​ children

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Financial risks posed by unproven cell interventions in Japan

The research group led by Professor Misao Fujita conducted a study to estimate the total amount of refund the Japanese government would pay if a patient received unproven cell interventions and applied for a medical expense deduction. Some regenerative medicines whose safety and efficacy have not been fully confirmed in clinical trials and other studies are offered

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Combination Respiratory Vaccine Containing Recombinant SARS-CoV-2 Spike and Quadrivalent Seasonal Influenza Hemagglutinin Nanoparticles results effective in animals trials

On Wednesday, Maryland-based vaccine manufacturer Novavax released preliminary results from an early clinical phase study of its combination Covid/flu vaccine. The results found that the combination vaccine produced immune responses in patients that were comparable to those of its standalone flu and Covid vaccines. The company also found the vaccine formulation to be safe, with

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Covid-19: Antidepressant Fluvoxamine Found to Be Effective as a therapy by Mc Gill University researchers

Researchers say the drug fluvoxamine is effective as an outpatient treatment for COVID-19. Experts say fluvoxamine could widen access to COVID-19 treatments, although they expect it to be a somewhat minor tool in the medical community’s toolkit. They also note that more studies need to be done on fluvoxamine’s effectiveness against the Omicron variant. Fluvoxamine,

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Regenerative Potential of Solid Bone Marrow Aspirate Concentrate Compared to Platelet-Rich Fibrin

A new study compares the regenerative potential of blood/bone marrow aspirate concentrates obtained from arterial blood, venous blood, and bone marrow aspirate. The study, conducted in rabbits, is reported in the peer-reviewed journal Tissue Engineering Part A. Blood concentrate material such as platelet-rick fibrin (PRF) is used in clinical practice to promote tissue regeneration in the

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Three in ten survivors with COVID-19 developed a subset of symptoms associated with “Long Covid”: study of UCLA shows

New UCLA research finds that 30% of people treated for COVID-19 developed Post Acute Sequelae of COVID-19 (PASC), most commonly known as “Long COVID.” People with a history of hospitalization, diabetes, and higher body mass index were most likely to develop the condition, while those covered by Medicaid, as opposed to commercial health insurance, or

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What impacts has Covid-19 had on children: CDC study shows 87% Of Kids Hospitalized During Omicron Wave Were Unvaccinated.

About 87% of children hospitalized with Covid-19 when the omicron variant was dominant were unvaccinated, according to a study released Tuesday by the Centers for Disease Control and Prevention, offering a stark reminder of the risks of leaving children unvaccinated. KEY FACTS From mid-December to late February, unvaccinated children ages 5 to 11 had a hospitalization rate

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3% of adults with COVID pneumonia develop new-onset dementia

Three percent of 10,403 adults with COVID-19 pneumonia were diagnosed as having new-onset dementia after a median of 182 days, a significantly higher proportion than that observed with other types of pneumonia, finds a study published in Open Forum Infectious Diseases. University of Missouri at Columbia researchers conducted a case series of COVID-19 pneumonia patients along

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COVID-19 therapy: better in combination than alone. Research published by Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU).

How a well-known drug can become a game changer There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs. Their findings, which have been published in Molecular Therapy, show

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New York State Department of Health Announces Emergence of Recently Identified, Highly Contagious Omicron Subvariants in New York and Urges Continued Vigilance Against COVID-19

The New York State Department of Health today announced the emergence of two Omicron subvariants in New York State, BA.2.12 and BA.2.12.1. Both variants are sub-lineages of BA.2, which now accounts for 80.6% of COVID-19 infections in New York. The subvariants have been estimated to have a 23% – 27% growth advantage above the original BA.2 variant.

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Cell-Derived Exosome Therapy May Help Repair Abnormal Heart Rhythm

Cedars-Sinai Investigators Found It Also Reduced Scarred Heart Tissue in Animals Vesicles secreted from human heart cells may repair damaged tissue and prevent lethal heart rhythm disorders, according to a new study from investigators in the Smidt Heart Institute at Cedars-Sinai. The research, published in the European Heart Journal, could lead to a new way to

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Cell Treatment Slows Disease in Duchenne Muscular Dystrophy Patients

Cell Therapy Developed by Smidt Heart Institute Leader Delays Disease Progression in Patients Who Have Few Treatment Options A cell therapy developed by the executive director of the Smidt Heart Institute stabilizes weakened muscles–including the heart muscle–in Duchenne muscular dystrophy patients, a new study published in the international peer-reviewed journal The Lancet shows. If the HOPE-2 study’s

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University of Manitoba researchers develop new stem cell therapy for treating spinal cord injuries

A new study by University of Manitoba researchers has developed a stem cell-based therapy that may eventually lead to new regenerative treatments for people with spinal cord injuries. Dr. Soheila Karimi, professor of physiology and pathophysiology at the Max Rady College of Medicine, Rady Faculty of Health Sciences, and her colleagues have developed a treatment strategy that

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Aprotinin is effective in COVID-19 patients: Ciudad Real University researchers clinical trial confirms previous data of Goethe and Kent University

A clinical study from Spain recently confirmed laboratory experiments made by researchers of Goethe University Frankfurt and University of Kent who showed that the protease inhibitor aprotinin prevented cells to be infected by SARS-CoV2. The authors of the clinical study report that patients receiving an aprotinin aerosol could be discharged from hospital significantly earlier. SARS-CoV-2, the

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FDA approves axicabtagene ciloleucel CAR-T cells for second-line treatment of large B-cell lymphoma

On April 1, 2022, the Food and Drug Administration approved axicabtagene ciloleucel (Yescarta, Kite Pharma, Inc.) for adult patients with large B-cell lymphoma (LBCL) that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy. It is not indicated for the treatment of patients with primary central nervous system lymphoma. Approval was

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Natural Killer Cells Complexed With a Bispecific Antibody May Provide New Treatment Option for Patients With Advanced Lymphoma

Natural killer (NK) cells derived from cord blood that were activated and complexed with a CD30/CD16A bispecific antibody elicited an 89 percent overall response rate in patients with relapsed or refractory CD30+ lymphoma, according to results from a phase I/II clinical trial presented at the AACR Annual Meeting 2022, held April 8-13. “We were favorably surprised by the

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Inappropriate Antibiotics Prescriptions Associated With COVID-19 Outpatient Visits Among Medicare Beneficiaries, April 2020 to April 2021: study published on JAMA

Antibiotics are ineffective treatment for viral syndromes, including COVID-19. Was characterized antibiotic prescribing in older adults with outpatient COVID-19 visits to identify opportunities to improve prescribing practices. Were used 100% Medicare carrier claims and Part D event files to identify beneficiaries with a COVID-19 outpatient visit and associated antibiotic prescriptions. We included beneficiaries aged 65

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Study found substantial use of systemic corticosteroids for non-hospitalized patients with COVID-19, contrary to NIH treatment guidelines advising against such intervention in mild to moderate cases.

In June 2020, preliminary results for the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial conducted in the UK indicated benefit from dexamethasone in severely ill hospitalized patients with COVID-19 but potential harm in those not requiring oxygen. In October 2020, the National Institutes of Health (NIH) issued COVID-19 treatment guidelines advising against systemic corticosteroid use

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Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy

CD19 CAR T-cell therapy is effective at achieving durable remission for relapsed/refractory ALL across cytogenetic risk groups. CD19 CAR T-cell treatment results for patients with high-risk cytogenetics including Ph+, Ph-like, and KMT2A-rearranged ALL are encouraging. Chimeric antigen receptor (CAR) T-cell therapy can induce durable remissions of relapsed/refractory B-acute lymphoblastic leukemia (ALL). However, case reports suggested differential

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COVID-19: brain impact of SARS-CoV-2 on the nervous system

Emerging studies have increasingly recognized Covid-19 as an inflammatory disease. Brain shrinkage, brain-blood barrier disruptions and neurodegeneration seem to emerge as an inflammatory consequence of acute infection that for some progresses into Long Covid. Cognitive impairments are consistently reported as one of the most persistent and some of the more impairing symptoms of Long Covid.

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ALY101 molecule holds promise in potential therapies for cancer and rare diseases

Researchers at the University of California, Irvine and the Italian Institute of Technology have developed a new molecule, ALY101, that shows promising anti-cancer activity against a wide range of tumor cell types and in mouse models of a common type of melanoma. The findings, “Structure-based Design of CDC42 Effector Interaction Inhibitors for the Treatment of

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Penn Medicine Study: Pulse Oximeters Did Not Change Outcomes for Patients in COVID-19 Monitoring Program

Already monitored for worsening symptoms via automated text messages, patients with pulse oximeters in the COVID Watch program had similar recovery to those without them. Using a pulse oximeter to measure oxygen levels is no better than just regularly asking patients with COVID-19 if they are short of breath, according to new research at the

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Covid-19 increases the risk of blood clots up to six months after infection

The risk of pulmonary embolism and venous thrombosis is multiplied by a corona infection. According to a new study of all those who tested positive in Sweden, this applies six months after the diagnosis. According to a study, people infected with SARS-CoV-2 have an increased risk of developing severe blood clots for up to six months after infection . According

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A Mount Sinai-led team developed a reproducible and scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)

A study reporting this new protocol was published in the April 7 print edition of the journal Cell Stem Cell. A Mount Sinai-led team has developed a reproducible and scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)—cells that support heart muscle contraction, generated in the lab from human stem cell lines—which researchers

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Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A

BACKGROUND Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)–based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective promoter. The efficacy and safety of the therapy were previously evaluated in men with severe hemophilia A in a phase 1–2 dose-escalation study. METHODS Was conducted an open-label, single-group, multicenter, phase 3

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CAR T cells expressing a pluripotent pro-inflammatory neutrophil-activating protein (NAP) from Helicobacter pylori to better fight cancer

Immunotherapy is increasingly becoming a successful way to treat cancer. Researchers at Uppsala University have now developed armed CAR-T cells that reinforce the immune defense against cancer and that could increase the possibilities to successfully treat solid tumors. The study has been published in the journal Nature Biomedical Engineering. The use of immunotherapy to treat cancer

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SARS-CoV-2 triggers massive inflammation: result of a study published by Children’s Hospital in Nature

A study led by researchers at Boston Children’s Hospital explains for the first time why COVID-19 causes severe inflammation in some people, leading to acute respiratory distress and multi-organ damage. Surprisingly, the study also finds that antibodies that people develop when they contract COVID-19 can sometimes lead to more inflammation, while antibodies generated by mRNA

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Johns Hopkins-Led Study Finds Convalescent Plasma Can Be Effective Early COVID-19 Therapy

Peer-reviewed publication in New England Journal of Medicine validates findings first announced in December The New England Journal of Medicine (NEJM) today published final results of a nationwide multicenter study led by researchers at Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health that show plasma from patients who have recovered from COVID-19 and whose blood contains

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Specialized Liver Blood Vessel Identity Factor Required for Regeneration

Researchers at Weill Cornell Medicine have identified a key protein that induces the program to build specialized liver blood vessels. The discovery could lead to engineered replacement hepatic tissue to treat common liver diseases. There are many types of blood vessels in the human body that are functionally different from each other. In the liver,

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Johns Hopkins-Led Study Finds Convalescent Plasma Can Be Effective Early COVID-19 Therapy

Peer-reviewed publication in New England Journal of Medicine validates findings first announced in December The New England Journal of Medicine (NEJM)  published final results of a nationwide multicenter study led by researchers at Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health that show plasma from patients who have recovered from COVID-19 and whose blood

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For children aged under 5, the incidence rate of SARS-CoV-2 infection is higher with the omicron versus the delta variant

For children aged under 5, the incidence rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was higher with the omicron variant versus the delta variant, according to a research letter published online April 1 in JAMA Pediatrics. Lindsey Wang, from the Case Western Reserve University School of Medicine in Cleveland, and colleagues examined incidence

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SARS-CoV-2 innate defense system: the role of neutrophil and epithelial defensins

One of the most important layers of our body’s defense against SARS-CoV-2 lies in our innate immune system. The innate immune system protects our body from microbes, viruses, bacteria, and parasites that we have not previously encountered. While much of public attention and awareness of human immunity is focused on adaptive or learned immunity, innate

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In animal study, implant churns out CAR-T cells to combat cancer

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed an implantable biotechnology that produces and releases CAR-T cells for attacking cancerous tumors. In a proof-of-concept study involving lymphoma in mice, the researchers found that treatment with the implants was faster and more effective than conventional CAR-T cell

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Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17 CAR T cells without toxicity to normal tissues

Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet. Researchers at Penn Medicine have discovered that CAR-T cells directed to a tumor antigen, CDH17, a cell surface marker expressed on both NETs and GICs but also

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Anti-nausea drugs may increase the risk of stroke, according to a new study from Inserm.

Taking drugs to fight nausea and vomiting can increase the risk of ischemic stroke, according to a new study from Inserm. Increased risks from the first days of treatment. Anti Dopaminergic Antiemetics are associated with an increased risk of developing a stroke . It was researchers from Inserm and the University of Bordeaux who highlighted this link. The results have been

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Most anti-PF4 antibodies in Covid-19 vaccine-induced immune thrombotic thrombocytopenia are transient

Platelet-activating anti-PF4 antibodies in VITT are transient in >90% of patients. Likely VITT patients can safely receive a second vaccination shot with an mRNA vaccine, independent of their VITT-antibody status. Vaccine-induced thrombotic thrombocytopenia (VITT) is triggered by vaccination against COVID-19 with adenovirus vector vaccines (ChAdOx1 nCoV-19; Ad26.COV2-S). In this observational study, were followed VITT patients

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“Deltacron” a combination of the delta (AY.4) and BA.1 omicron variants named by the WHO as the BA.1 x AY.4 recombinant.

A combination of the delta (AY.4) and BA.1 omicron variants has been named by the World Health Organization as the BA.1 x AY.4 recombinant. First detected in France in January 2022, it has since picked up the nickname “deltacron”1 How does a recombinant emerge? Recombinants can emerge when multiple variants infect the same person at

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American College of Cardiology Issues Clinical Guidance on CardioVascular Consequences of COVID-19

A new Expert Consensus Decision Pathway released by the ACC addresses the evaluation and management of some of the more common cardiovascular sequelae in adults with COVID-19. The Pathway, published March 16 in the Journal of the American College of Cardiology, specifically addresses myocarditis and other types of myocardial involvement, patient-centered approaches for long COVID, and

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Huge step forward towards gene therapy and diagnosis for genetic eye disease

New opportunities towards gene therapy and diagnosis for the blinding eye disease, retinal dystrophy, may now become available following work done by the Eye Genetics Research Unit at Children’s Medical Research Institute. This work was published in the Journal of Personalized Medicine today. The team looked at the RPGR gene which is involved in maintaining

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Kids with rare autoimmune disease antiphospholipid syndrome show these symptoms before blood clots 

Antiphospholipid syndrome is rare in adults and even less common among children.  Each year, around two of every 100,000 American adults receive a new diagnosis of antiphospholipid syndrome, or APS, an autoimmune disease known to cause inflammation and recurring, potentially fatal, blood clots. The number of children with APS is likely much smaller but unknown –

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Excess Neuropeptides Disrupt Lung Function in Infant Disease and COVID-19

UC San Diego study identifies lung neuroendocrine cells as drivers of developmental lung disease; similar mechanism may contribute to COVID-19 symptoms COVID-19 has put a spotlight on the pulmonary and nervous systems, but there is still much to learn about how they interact. Researchers at University of California San Diego School of Medicine recently explored

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Cardiac damage as a side effect of CAR-T cell cancer therapy

CAR-T-cell cancer therapy uses special T-cells that are specifically directed towards tumor antigens, the so-called (CAR)-T-cells. These cells trigger a targeted immune response that helps the body recognize and fight cancer cells. But, like other cancer therapies, the treatment can cause unwanted side effects, such as affecting heart function. Scientists from the Medical Faculty of the University

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Global death toll of COVID-19 pandemic may be more than three times higher than official records, estimates published on Lancet indicate

More than three times as many people may have died worldwide as a result of the pandemic than official COVID-19 death records suggest, according to an analysis published in The Lancet. While the official COVID-19 death toll was 5.9 million between January 1, 2020, and December 31, 2021, the new study estimates 18.2 million excess deaths

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Cellular therapy improves signs and symptoms of Duchenne muscular dystrophy

Clinical trial results promising for people with the debilitating disorder A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people. The therapy appears to be safe and effective

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Finding a treatment for critically ill COVID-19 patients: alpha-1 antitryspin clinical trial

A clinical trial conducted by researchers from RCSI University of Medicine and Health Sciences and Beaumont Hospital Dublin has indicated an effective treatment for critically ill COVID-19 patients. The study, published today in Med, investigates the effects of using an anti-inflammatory protein, alpha-1 antitryspin (AAT), to treat COVID-19 patients who have progressed to acute respiratory distress

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Neuro Long-Covid explained

Two studies published this week have added to a growing body of evidence linking covid infection to subsequent cognitive impairment, even in cases of less severe disease. One study, a preprint published in Nature, examined 785 UK Biobank participants aged 51-81 who routinely receive brain scans and cognitive testing as part of the Biobank’s data gathering. About

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Coagulation proteases and Direct Oral Anticoagulants impact on cancer growth and metastasis

The hemostatic system in cancer The hemostatic system forms an integral part of the innate immune system and contributes to tumor growth and metastasis. Many malignancies are associated with a hyper-thrombotic state that derives foremost from tissue factor (TF), the initiator of the coagulation cascade, expressed by tumor cells and innate immune cells and stromal

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RECOVERY trial shows Baricitinib reduces deaths in patients hospitalised with COVID-19

The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial has demonstrated that baricitinib, an anti-inflammatory treatment normally used to treat rheumatoid arthritis, reduces the risk of death when given to hospitalised patients with severe COVID-19. The benefit was in addition to those of dexamethasone and tocilizumab, two other anti-inflammatory treatments which have previously been shown to

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COVID-19 infections increase risk of heart conditions up to a year later

Cardiovascular care essential part of post-infection care An analysis of federal health data indicates that people who have had COVID-19 are at increased risk of developing cardiovascular complications within the first month to a year after infection, according to researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis

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CAR-based therapies an opportunity for immuno-medicine beyond cancer: a review published on Nature Metabolism

CAR T therapy has had enormous impact in some areas of oncology, and notable efforts are underway to extend the success to additional forms of cancer. However, the use of engineered T cells may be evenmore attractive for disorders other than cancer for several reasons. This review analyses different opportunities and future directions. First, for

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Connecting science to medicine: tendon-like tissue created from human stem cells

Researchers from Tokyo Medical and Dental (TMDU) develop artificial tendons in vitro from human stem cells that could fix common tendon injuries such as Achilles tendon rupture.  Tendons are tissues that connect muscles to bones and are important for movement and locomotion. Injuries to tendons are quite common, with millions of people – particularly athletes

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Gene Therapy for Thalassemia Ends Need for Transfusions in Young Children

Phase 3 clinical trial included children younger than 12 years Over 90 percent of patients with transfusion-dependent thalassemia, an inherited blood disorder, no longer needed monthly blood transfusions years after receiving gene therapy, according to an international Phase 3 clinical trial that for the first time included children younger than 12 years of age. Twenty-two patients

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A new study shows MIS-C is rare among teens COVID-19 vaccinated

COVID-19 vaccines are unlikely to trigger a rare inflammatory condition linked to coronavirus infection in children, according to an analysis of U.S. government data published Tuesday. The condition, formally known as multisystem inflammatory syndrome in children, involves fever plus symptoms affecting at least two organs and often includes stomach pain, skin rash or bloodshot eyes. It’s

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Mesenchymal stem cell‑based treatments for COVID‑19: an updated review

This review describes the origins, pathogenesis, and clinical features of COVID-19 and the potential uses of mesenchymal stem cells (MSCs) in therapeutic treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients. MSCs have previously been shown to have positive effects in the treatment of lung diseases, such as acute lung injury, idiopathic pulmonary fibrosis,

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Vertebral body tethering: Another option for treating scoliosis in children

Fusion surgery has been the long-standing treatment for people with scoliosis – a side-to-side curve of the spine. But other options have become available — including vertebral body tethering for children with scoliosis. “Vertebral tethering is a new tool in the tool kit for the treatment of scoliosis,” says A. Noelle Larson, M.D., a pediatric orthopedic surgeon at Mayo

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Foreseeing the future of European medicine

Experts say careful application of advanced tech could usher in a golden age of healthcare New technologies could enable medicine to progress in leaps and bounds, but only with the right regulatory and ethical frameworks. That was one of the messages from panelists discussing the future of medicine at the Science|Business conference Horizon Europe: The first assessment as

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Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment: a review published on Frontiers

In this review, it’s provided an overview of the major mechanisms used by tumor cells to evade immune defenses and are critically exposed the most optimistic engineering strategies to make CAR-T cell therapy a solid option for solid tumors. CAR-T cell based cell therapy is a moving field, which showed impressive results in hematopoietic cancer

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Ivermectin and Hydroxychloroquine 2020 prescriptions for Covid-19 shown highest in GOP-Dominated Counties: a JAMA Research Letter shows.

New prescriptions of hydroxychloroquine (HCQ) and ivermectin increased in 2020, driven particularly by rates in counties with the highest proportion of Republican votes in the 2020 US presidential election, according to a cross-sectional study published today in JAMA Internal Medicine. “Our findings are consistent with the hypothesis that US prescribing of hydroxychloroquine and ivermectin during the COVID-19 pandemic may have

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Randomized trial published on JAMA Internal Medicine confirms Ivermectin is ineffective against progression to Severe COVID

Ivermectin treatment given to high-risk patients with mild-to-moderate COVID-19 during the first week of illness did not prevent progression to severe disease, according to results from a randomized clinical trial. “The study findings do not support the use of ivermectin for patients with COVID-19,” researchers conclude in the paper published online today in JAMA Internal Medicine. The open-label

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Vitamins do not lessen chance of dying from COVID-19: review published by University of Toledo researchers.

A new review of COVID-19 hospitalization data by researchers at The University of Toledo has found that taking immune-boosting supplements such as vitamin C, vitamin D and zinc do not lessen your chance of dying from COVID- Early in the pandemic, healthcare providers tried a variety of micronutrients as potential therapies for the new illness. More recently,

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COVID-19 vaccination may protect against variants better than natural infection, Stanford University study finds

COVID-19 vaccines are better than infection at making antibodies to recognize new viral variants, according to a Stanford study. Antibodies generated by COVID-19 vaccines are more suited to recognizing viral variants than antibodies that arise from natural infection, according to a study by researchers at Stanford Medicine. A key finding of the study might explain why: Regions

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NIH researchers Pinpoint “Rogue Autoantibodies” Associated With Severe COVID-19 Blood Clotting

What After studying blood samples from 244 patients hospitalized for COVID-19, a group of researchers, including those who work at the National Institutes of Health, identified “rogue antibodies” that correlate with severe illness and may help explain mechanisms associated with severe blood clotting. The researchers found circulating antiphospholipid antibodies, which can be more common among people

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The effectiveness of vaccination against long COVID: a rapid evidence briefing by UK Health Security Agency

People who had been fully vaccinated against covid-19 were around half as likely to develop long covid symptoms as people who had received only one vaccine dose or were unvaccinated, the UK Health Security Agency has said. The agency conducted a rapid review of evidence, including 15 UK and international studies up to January 2022.

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Creating universal blood-type organs for transplant

A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN’s Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. This finding is an important step towards creating universal type O organs, which would significantly improve fairness in organ allocation

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First gene therapy for Tay-Sachs disease successfully given to two children

Two babies have received the first-ever gene therapy for Tay-Sachs disease after over 14 years of development. Tay-Sachs is a severe neurological disease caused by a deficiency in an enzyme called HexA. This enzyme breaks down a fatlike substance that normally exists in very small, harmless amounts in the brain. Without HexA, however, this fatlike substance can accumulate

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Virome characterization of wild mammalian game animals, traded and consumed as exotic food in China, reveals a spectrum of emerging pathogens

This study has greatly expanded the understanding of the diversity of viruses carried by a variety of wild animals, and provided an important scientific basis for the early warning and prevention of human and livestock diseases.Vertebrate-associated viruses carried in wildlife The world’s top academic journal Cell published a research paper online: “Virome characterization of game

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U.S. peer-reviewed study on Omicron patient outcomes reveals significant differences in infection behavior

Within only three weeks after the Omicron variant was first identified among Houston Methodist patients, this variant rapidly took over and became the cause of a majority of new cases. By contrast, the delta variant took about three months to reach that same milestone after initial detection. Causing 98 percent of all new COVID-19 cases

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Using stem cells to regenerate the heart: identified key molecule for recognizing epicardial cells, the source of many cell types in a growing heart.

Heart disease remains the leading cause of death in the world. One reason is that unlike other tissues, such as bone and skin, the heart has remarkably poor regenerative capability after an injury such as a heart attack. Scientists have therefore searched for heart cells that have regenerative properties. A new study by the Yoshinori

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Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott–Aldrich syndrome

Genethon, a unique non-profit gene therapy R&D organization founded by the French Muscular Dystrophy Association (AFM-Telethon), announced today that its lentiviral based gene therapy, developed in collaboration with French and British teams, has demonstrated long-term efficacy in eight patients with Wiskott-Aldrich syndrome, a rare and severe immune deficiency. “These results confirm the stability and good

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COVID-19 infections increase risk of heart conditions up to a year later

Cardiovascular care essential part of post-infection care An in-depth analysis of federal health data indicates that people who have had COVID-19 are at increased risk of developing cardiovascular complications within the first month to a year after infection. Such complications include disruptive heart rhythms, inflammation of the heart, blood clots, stroke, coronary artery disease, heart

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Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis in three patients as published in Nature Medicine

A system developed by Grégoire Courtine and Jocelyne Bloch now enables patients with a complete spinal cord injury to stand, walk and even perform recreational activities like swimming, cycling andcanoeing. The images made headlines around the world in late 2018. David Mzee, who had been left paralyzed by a partial spinal cord injury suffered in

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Gene therapy in transfusion-dependent beta-thalassemia

A novel gene therapy promoted transfusion independence in more than 90 percent of adult and pediatric patients with transfusion-dependent beta-thalassemia, according to a recent clinical trial published in The New England Journal of Medicine. The therapy represents a potentially curative treatment option for patients who must otherwise rely on life-long red blood cell transfusions. This approach provides

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Study of Penn Patients with Decade-Long Leukemia Remissions after CAR T Cell Therapy Reveals New Details About Persistence of Personalized “Living Drug” Cells

Two patients represent longest-known CAR T cell response to date, providing insight into treatment effects and outcomes In the summer of 2010, Bill Ludwig and Doug Olson were battling an insidious blood cancer called chronic lymphocytic leukemia (CLL). They’d both received numerous treatments, and as remaining options became scarce, they volunteered to become the first

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FDA Takes Actions to Expand Use of Treatment for Outpatients with Mild-to-Moderate COVID-19

The U.S. Food and Drug Administration took two actions to expand the use of the antiviral drug Veklury (remdesivir) to certain non-hospitalized adults and pediatric patients for the treatment of mild-to-moderate COVID-19 disease. This provides another treatment option to reduce the risk of hospitalization in high-risk patients. Previously, the use of Veklury was limited to

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Landing therapeutic genes safely in the human genome

Researchers at Harvard’s Wyss Institute, Harvard Medical School, and the ETH Zurich predict and validate genomic safe harbors for therapeutic genes, enabling safer, more efficient, and predictable gene and cell therapies. Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and

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Current vaccines teach T and B cells to fight Omicron: results published in two new papers

Scientists at La Jolla Institute for Immunology (LJI) have found that four COVID-19 vaccines (Pfizer-BioNTech, Moderna, J&J/Janssen, and Novavax) prompt the body to make effective, long-lasting T cells against SARS-CoV-2. These T cells can recognize SARS-CoV-2 Variants of Concern, including Delta and Omicron.  “The vast majority of T cell responses are still effective against Omicron,”

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Two new papers reveal through cryo-EM analysis the structural basis of antibody evasion and enhanced transmission of the Omicron variant

In a study recently published on Cell, researchers used cryogenic electron microscopy (cryo-EM) analysis to capture the open and closed states of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant’s spike protein. The open and closed states of the Omicron spike appeared more compact compared to that of the SARS-CoV-2 G614 strain, which is likely due to

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Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae: a new paper published on Cell

A significant portion of people who contract the SARS-CoV-2 virus—some estimates suggest more than 40 percent—suffer chronic effects known as Post Acute Sequelae of COVID-19 (PASC), commonly referred to as long COVID. PASC symptoms include fatigue, brain fog, the loss of taste and smell, shortness of breath, and more. Now, researchers have identified several factors

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New gene therapy treatment resulted in sustained, clinically relevant benefits in children with Metachromatic Leucodystrophy: long term results published.

An investigational gene therapy showed benefit in pediatric patients with early-onset metachromatic leukodystrophy (MLD), a small study showed. Treatment with atidarsagene autotemcel (arsa-cel) preserved motor development and cognitive function in MLD patients enrolled in a prospective phase I/II trial or treated through expanded access programs, reported Alessandro Aiuti, MD, of the San Raffaele Telethon Institute for Gene

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50-64 age unvaccinated people were 44 more times to be hospitalized with COVID-19 than those who were fully vaccinated and had a booster shot, CDC shows

The risk of hospitalization for COVID-19 among older Americans is far higher for those who are unvaccinated than for those who are fully vaccinated and have had a booster shot, new government data shows. The differences were stark: In December, unvaccinated people 50 and older were 17 times more likely to be hospitalized with COVID-19 than those

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New EMA report on International regulators’ recommendations on COVID-19 vaccines and the Omicron variant

International regulators have published a report today highlighting their discussions on the effectiveness of current vaccines against the COVID-19 Omicron variant, regulatory requirements for a variant vaccine and considerations on clinical study design. The workshop on the global response to the COVID-19 Omicron variant was organised under the umbrella of the International Coalition of Medicines Regulatory Authorities (ICMRA) and

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Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury: a review

Peripheral nerve injury (PNI) refers to varying degrees of trauma to peripheral nerve stems or branches. PNIaccounts for 1.5–4.0% of global trauma cases annually and is one of the most challenging health issues at present. Nerve regeneration is a complicated cellular process involving infammation, neurotrophic factors, neurotransmitters, adhesion, the formation of axons and growth cones,

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Placebo Effect Accounts for More Than Two-Thirds of COVID-19 Vaccine Adverse Events, Researchers Find

One-Third of Clinical Trial Participants Who Received No Vaccine Reported Systemic Adverse Advents Like Headache and Fatigue The placebo effect is the well-known phenomenon of a person’s physical or mental health improving after taking a treatment with no pharmacological therapeutic benefit – a sugar pill, or a syringe full of saline, for example. While the

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Epilepsy Research Boosts Case for New Gene Therapy

Research from the School of Medicine suggests how a newly developed gene therapy can treat Dravet syndrome, a severe form of epilepsy, and potentially prolong survival for people with the condition. The gene therapy, developed by Stoke Therapeutics, is now in clinical trials. Because most Dravet syndrome cases are caused by a mutation in the SCN1A gene, resulting in

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SARS-CoV-2 variants of concern and variants under investigation in England: technical briefing published by UK Health Security Agency

This report has been published to share the detailed variant surveillance analyses which contribute to the variant risk assessments and designation of new variants of concern (VOC) and variants under investigation (VUI). This specialist technical briefing contains early data and analysis on emerging variants and findings have a high level of uncertainty. SARS-CoV-2 Routine variant

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Association between vaccination status and reported incidence of post-acute long-COVID-19 symptoms in Israel: double dose Pfizer-BioNTech vaccination may have a protective effect.

An emerging and complex health problem that remains poorly characterized and understood is long coronavirus disease 2019 (Long COVID). The rapid outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Long COVID is a post-infection condition in which individuals do not recover completely for

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Viral dynamics and duration of PCR positivity of the SARSCoV-2 Omicron variant: a study of Harvard University researchers on NBA players

A significant proportion of people infected with the omicron variant of coronavirus were still contagious when they reach the U.S. Centers for Disease Control’s recommended self-isolation exit date of five days, according to a  Harvard University study of a small number of cases from the National Basketball Association’s Covid-19 testing program. KEY FACTS Among omicron cases identified 

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COVID-19 nonhospitalized patients: therapeutic options review in Omicron era

Substantial progress has been made in therapeutics for nonhospitalized patients with COVID-19, but supply of and access to treatment remain limited. This Viewpoint summarizes currently available therapeutics for nonhospitalized patients in the setting of the Omicron variant including principles for equitable allocation. Patients with mild or moderate COVID-19 are those who have respiratory and systemic

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NIH researchers develop first stem cell model of albinism to study related eye conditions

A human induced pluripotent stem cell colony from OCA1A patient. The image was acquired using a confocal microscope and is stained for pluripotency marker proteins. The red color depicts transcription factor OCT4, green is SSEA4 protein and blue represents the nucleus of the cells.NEI “Animals used to study albinism are less than ideal because they

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CAR-T-cell therapy has the potential to replace chemoimmunotherapy for second-line treatment of patients with refractory or relapsed large B-cell lymphoma (LBCL)

In the ZUMA-7 trial, at a median follow-up of 24.9 months, patients randomly assigned to receive CAR T-cell therapy with axicabtagene ciloleucel, or axi-cell (Yescarta) had a median event-free survival (EFS) of 8.3 months, compared with 2 months for patients randomly assigned to standard-of-care chemoimmunotherapy, reported Frederick L. Locke, MD, from the Moffitt Cancer Center

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Illinois College University researchers uncover new information about cellular death process, previously thought to be irreversible

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis — the process of cell death that is usually caused by infections and results in excess inflammation in the body — and shows that process, long thought to be irreversible once initiated, can in fact be halted

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A Japan National Institute of Infectious Diseases Control and Prevention Center study shows that Peak Infectiousness Of Omicron variant is 3-6 Days After Symptom Onset.

A new study conducted by Japanese researchers has shown that peak viral loads in people infected with omicron occur between 3 to 6 days after the onset of symptoms. The study raises further concerns about the CDC cutting the self-isolating time for people with Covid-19 to 5 days, not 10. The report was published online on January

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Naive T-cell depletion approach results in lower rates of chronic GVHD after transplant

Removing one type of T cell from donor blood used for stem cell grafts could greatly reduce a serious complication called graft-versus-host disease in patients with leukemia, according to a new study. Published today in the Journal of Clinical Oncology, the study reports that only 7% of leukemia patients who received stem cell transplants depleted of

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Single injection of messenger RNA Can Be Used to Make CAR T cells in vivo and to attack fibrosis in heart failure .

Penn study reveals an easier, more scalable way to make a powerful immunotherapy An experimental immunotherapy can temporarily reprogram patients’ immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine

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National Strategy for the new normal life with Covid-19: three papers published on JAMA

Today, a group of eminent physicians and scientists with global standing have acted decisively and in unison presenting the world with what it badly needs, whether it knows it or not: a comprehensive, cohesive plan which lays out the steps to reverse the course of Covid-19. Presented today as three linked “Viewpoints” in one of the world’s

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Predicting the future of COVID: Boston College biologists develop a computational model to detect emerging Coronavirus strains

Efforts to contain the spread of SARS-CoV-2 may benefit from a new analytical tool developed by a team led by biologists at Boston College, who report their computer simulation of molecular interactions can predict mutations of the virus and help develop insights into future variants of concern before they emerge. “We computationally predict what mutations

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A study of Infectious Economics in New York identifies discordant SARS-CoV-2 PCR and Rapid Antigen Test Results When Infectious

Anew study raises significant doubts about whether at-home rapid antigen tests can detect the Omicron variant before infected people can transmit the virus to others. The study looks at 30 people from settings including Broadway theaters and offices in New York and San Francisco where some workers were not only being tested daily but were, because

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Need for long-term monitoring of children born during the COVID-19 pandemic: a study shows differences in neurodevelopment at age 6 months.

A new paper published on JAMA Pediatrics by researchers of Columbia University Irving Medical Center analyses a ssociations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment which are speculated, but currently unknown. To examine the associations between maternal SARS-CoV-2 infection during pregnancy, being born during the COVID-19 pandemic regardless of maternal SARS-CoV-2 status,

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Study: COVID-19 Hospitalization Costs, Outcomes In 2020 Improved Over Time

The first comprehensive analysis of its kind examines hospital inpatient costs and length of stay. A new study published in Advances in Therapy provides the first comprehensive analysis of the hospitalization costs for COVID-19 patients, factors associated with costs and length of stay, and the monthly trends of costs and length of stay from April to December

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South-Africa Netcare sees ‘significantly fewer’ Omicron patients with existing illnesses at its hospitals

In South Africa, the pattern of patients hospitalized with COVID-19 early in the fourth wave showed fewer hospitalizations and reduced severity of illness compared with earlier waves, according to a research letter published online Dec. 30 in the Journal of the American Medical Association. Caroline Maslo, M.D., Ph.D., from Netcare Ltd. South Africa in Johannesburg, and

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COVID-19 patients have severely increased levels of oxidative stress and oxidant damage, and glutathione deficiency

Researchers at Baylor College of Medicine have investigated the effect of infection with COVID-19 on the levels of oxidative stress, oxidant damage and glutathione, the most abundant physiological antioxidant. Compared to healthy age-matched individuals whose samples were taken before the pandemic started in 2019, patients hospitalized with COVID-19 had significantly increased levels of oxidative stress and

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Lymphoma Cell Metabolism May Provide New Cancer Target

Diffuse large B-cell lymphoma. Photograph by CoRus13, distributed under a CC BY-SA 4.0 license Aggressive and relatively common lymphomas called diffuse large B cell lymphomas (DLBCLs) have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves, according to a study from researchers at Weill Cornell Medicine and Cornell’s Ithaca campus.

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Emergence in Southern France of a new SARS-CoV-2 variant named B.1.640.2 of probably Cameroonian origin harbouring both substitutions N501Y and E484K in the spike protein and present in 67 hospitalised patients

A new coronavirus variant has been discovered in southern France, spreading in a small outbreak, according to a new study.The variant, tentatively identified B.1.640.2 according to a recent study backed by the French government that has yet to be peer-reviewed, is believed to be Cameroonian in origin and have so far spread to 67 patients in southern France.

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A potential at-home COVID-19 test is just as good as laboratory PCR tests, according to preclinical data

Researchers at the University of Illinois Chicago have designed a high-quality assay that can be used in at-home tests for rapid COVID-19 screening. Results from an early preclinical study suggest that tests with the new assay may be just as reliable as the laboratory-based molecular tests — called PCR tests — used by hospitals for clinical diagnostics.  “Having fast and

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Sloan Kettering Institute Scientists Retool CAR T Cells to Serve as ‘Micropharmacies’ for Cancer Drugs

Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient’s own immune cells to fight cancer. These treatments have energized cancer care, especially for people with certain types of blood cancers. Now, scientists at Memorial Sloan Kettering Cancer Center’s Sloan Kettering Institute (SKI) have developed new CAR T cells that can do something their

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Complement activation induces excessive T cell cytotoxicity in severe COVID-19, associated with fatal outcome.

A new paper published in Cell by Charitè group opens new perspectives to complement role in Covid-19 Highlights •Severe COVID-19 is marked by activated, highly cytotoxic CD16+ T cells •Immune complex-mediated degranulation of CD16+ T cells causes endothelial cell injury •C3a-rich environment in severe COVID-19 promotes differentiation of CD16+ T cells •Activated CD16+ T cells and complement proteins are

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Analysis of COVID-19 Vaccine Type and Adverse Effects Following Covid-19 Vaccination

This article was originally published here JAMA Netw Open. 2021 Dec 1;4(12):e2140364. doi: 10.1001/jamanetworkopen.2021.40364. ABSTRACT IMPORTANCE: Little is known about the factors associated with COVID-19 vaccine adverse effects in a real-world population. OBJECTIVE: To evaluate factors potentially associated with participant-reported adverse effects after COVID-19 vaccination. DESIGN, SETTING, AND PARTICIPANTS: The COVID-19 Citizen Science Study, an online

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Targeting the fibrin-neutrophil interaction prevented bone loss from periodontal disease

Human and animal study offers insight into treating periodontal disease and other inflammatory disorders. Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health. Drawing on animal

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When and how to use the existing tests to detect SARS-CoV-2 virus

“Test, test, test.” This is how Tedros Adhanom , director general of the World Health Organization (WHO), urged the countries  at the beginning of the covid-19 pandemic. Testing, isolation and contact tracing should be – and have been in many cases – the “backbone of the global response” to the crisis, according to the head of the agency. According to experts,

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The Omicron variant is highly resistant against antibody-mediated neutralization: a new study on Cell shows

The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. In thi paper on Cell are reported that the Omicron spike was resistant against most therapeutic

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A NIH researchers study shows SARS-CoV-2 can persist in the body as long as 230 days

In what they describe as the most comprehensive analysis to date of the SARS-CoV-2 virus’s distribution and persistence in the body and brain, scientists at the U.S. National Institutes of Health said they found the pathogen is capable of replicating in human cells well beyond the respiratory tract. The results, released online Saturday in a

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Discovery Health, South Africa’s largest private health insurance administrator, releases at-scale, real-world analysis of Omicron outbreak based on 211 000 COVID-19 test results in South Africa.

Summary: Vaccine effectiveness: o The two-dose Pfizer-BioNTech vaccination provides 70% protection against severe complications of COVID-19 requiring hospitalisation, and 33% protection against COVID-19 infection, during the current Omicron wave. Reinfection risk: For individuals who have had COVID-19 previously, the risk of reinfection with Omicron is significantly higher, relative to prior variants. Severity: The risk of hospital admission

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CAR-HEMATOTOX score: a model for CAR T-cell–related hematologic toxicity in relapsed/refractory large B-cell lymphoma

Immunotherapy with so-called CAR-T cells has established itself for the treatment of various leukemias (blood cancer) and lymphomas (lymph gland cancer). A team led by Dr. Kai Rejeski and Prof. Marion Subklewe from the Medical Clinic III of the LMU Klinikum found that many patients suffer from a side effect that initially fell under the radar: a

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HKUMed researchers find Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung

A study led by researchers from the LKS Faculty of Medicine at The University of Hong Kong (HKUMed) provides the first information on how the novel Variant of Concern (VOC) of SARS-CoV-2, the Omicron SARS-CoV-2 infect human respiratory tract. The researchers found that Omicron SARS-CoV-2 infects and multiplies 70 times faster than the Delta variant

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Universal Coronavirus Vaccines: an Urgent Need. Global coronaviral approach requested by Fauci and NIH researchers

A growing body of scientific evidence, considered together with ecological reality, strongly suggest that novel coronaviruses will continue to infect bats and other animal reservoirs and potentially emerge to pose a pandemic threat to humans. To counter future coronavirus outbreaks, the global scientific and medical research community should focus a major effort now on three

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Blockade or deletion of IFN-gamma reduces macrophage activation without compromising CAR T function in hematologic malignancies

Blood Cancer Discovery, a journal of the American Association for Cancer Research, has published a research article demonstrating a novel approach that may reduce a serious adverse effect associated with chimeric antigen receptor (CAR) T-cell therapy, a form of immunotherapy. This research was presented at the American Society of Hematology Annual Meeting in Atlanta, Georgia

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Fostering experimental and computational synergy to modulate hyperinflammation in severe Covid-19

An international collaboration between researchers from the Center for Cooperative Research in Biosciences (CIC bioGUNE, Bilbao), the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourgand and the Department of Immunology of St Jude Children’s Research Hospital (Kanneganti Lab, Memphis) highlights how fostering synergies between computational and experimental studies can lead to important

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Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss

Scientists at Boston Children’s Hospital have successfully used gene therapy to reverse a form of genetic hearing loss in mice. The team corrected a gene mutation that affects sensory hair cells in the inner ear, and the new jigsaw-like method could help improve gene therapy for other disorders. The target of the new treatment was

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Risks of myocarditis, pericarditis, and cardiac arrhythmias are more likely associated with Covid-19 infection than with vaccination

Led by the University of Oxford, a team of UK-based researchers have today reported results of the largest ever study to compare the risks of cardiovascular events, such as myocarditis, pericarditis, and cardiac arrhythmia, between different vaccines and COVID-19 infection, and the first to investigate the association between cardiac events and the Oxford-AstraZeneca vaccine. While

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NIH National Eye Institute researchers identify potential AMD drugs with stem-cell based research tool

Model replicates features of complex disease and provides platform for screening existing drugs Using a stem-cell-derived model, researchers have identified two drug candidates that may slow dry age-related macular degeneration (AMD), a leading cause of blindness for which no treatment exists. The scientists, from the National Eye Institute (NEI), part of the National Institutes of

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FDA issued an EUA for New Long-Acting Monoclonal Antibodies for Pre-exposure Prevention of COVID-19 in patients with moderate to severely compromised immune systems or a history of severe adverse reactions to a COVID-19 vaccine

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for AstraZeneca’s Evusheld (tixagevimab co-packaged with cilgavimab and administered together) for the pre-exposure prophylaxis (prevention) of COVID-19 in certain adults and pediatric individuals (12 years of age and older weighing at least 40 kilograms [about 88 pounds]).  The product is only authorized

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A new brief of Health System Tracker examines how deaths from COVID-19 rank among other leading causes of death in the U.S. and vaccine saving of 163.000 deaths since June 2021.

This brief examines how deaths from COVID-19 rank among other leading causes of death in the U.S. We find that COVID-19 was the third leading cause of death in November 2021. We also find that in October, COVID-19 was the number 1 cause of death for people age 45-54 and in the top 7 leading

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